1. Neuronal Signaling
  2. CaMK

Calmidazolium chloride (Synonyms: R 24571)

Cat. No.: HY-103319 Purity: >99.0%
Handling Instructions

Calmidazolium chloride (R 24571) is a calmodulin (CaMK) antagonist, antagonizing CaM-dependent phosphodiesterase and calmodulin-induced activation of erythrocyte Ca2+-transporting ATPase with IC50s of 0.15 and 0.35 μM, respectively. Also in anti-cancer research. Calmidazolium binds to CaMK with a Kd of 3 nM.

For research use only. We do not sell to patients.

Calmidazolium chloride Chemical Structure

Calmidazolium chloride Chemical Structure

CAS No. : 57265-65-3

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Description

Calmidazolium chloride (R 24571) is a calmodulin (CaMK) antagonist, antagonizing CaM-dependent phosphodiesterase and calmodulin-induced activation of erythrocyte Ca2+-transporting ATPase with IC50s of 0.15 and 0.35 μM, respectively[1]. Also in anti-cancer research[2]. Calmidazolium binds to CaMK with a Kd of 3 nM.

IC50 & Target

Kd: 3 nM (Calmodulin)[3]

In Vitro

Calmidazolium chloride is widely used as a calmodulin (CaM) antagonist, but is also known to induce apoptosis in certain cancer cell lines. Calmidazolium chloride (3, 5, 7, 10 μM, 30 minutes-24 hours) inhibits growth of mouse F9 ECCs[2].

Cell Viability Assay[2]

Cell Line: Mouse F9 ECCs
Concentration: 3, 5, 7, 10 μM
Incubation Time: 30 minutes-24 hours
Result: The IC50s of Calmidazolium chloride treated F9 ECCs and E14 ESCs are 8.18 μM, and 12.69 μM[2].
References
Molecular Weight

687.70

Formula

C₃₁H₂₃Cl₇N₂O

CAS No.

57265-65-3

SMILES

ClC1=CC=C(COC(C2=CC=C(Cl)C=C2Cl)CN3C=C[N+](C(C4=CC=C(Cl)C=C4)C5=CC=C(Cl)C=C5)=C3)C(Cl)=C1.[Cl-]

Storage
Powder -20°C 3 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Purity: >99.0%

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Product Name:
Calmidazolium chloride
Cat. No.:
HY-103319
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Calmidazolium chloride

Cat. No.: HY-103319