1. Membrane Transporter/Ion Channel
  2. Sodium Channel
  3. Dibucaine hydrochloride

Dibucaine hydrochloride (Synonyms: Cinchocaine hydrochloride)

Cat. No.: HY-B0552A Purity: 99.94%
Handling Instructions

Dibucaine hydrochloride (Cinchocaine hydrochloride) is a sodium channel inhibitor. Dibucaine hydrochloride is a potent SChE inhibitor.

For research use only. We do not sell to patients.

Dibucaine hydrochloride Chemical Structure

Dibucaine hydrochloride Chemical Structure

CAS No. : 61-12-1

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Based on 1 publication(s) in Google Scholar

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Description

Dibucaine hydrochloride (Cinchocaine hydrochloride) is a sodium channel inhibitor. Dibucaine hydrochloride is a potent SChE inhibitor[1][2].

In Vitro

Dibucaine hydrochloride (Cinchocaine hydrochloride) reduced the degradation of BSA-gold complex in the reservosomes, which was not caused either by an inhibition of the whole proteolytic activity of the parasite or by a reduction on the expression levels of cruzipain[1]. Dibucaine, a quaternary ammonium compound, inhibited SChE to a minimum within 2 min in a reversible manner. The inhibition was very potent. It had an IC(50) of 5.3 microM with BuTch or 3.8 microM with AcTch. The inhibition was competitive with respect to BuTch with a K(i) of 1.3 microM and a linear-mixed type (competitive/noncompetitive) with respect to AcTch with inhibition constants, K(i) and K(I) of 0.66 and 2.5 microM, respectively. Dibucaine possesses a butoxy side chain that is similar to the butryl group of BuTch and longer by an ethylene group from AcTch[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

379.92

Formula

C₂₀H₃₀ClN₃O₂

CAS No.

61-12-1

SMILES

O=C(C1=CC(OCCCC)=NC2=CC=CC=C12)NCCN(CC)CC.Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 110 mg/mL (289.53 mM; Need ultrasonic)

H2O : 100 mg/mL (263.21 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.6321 mL 13.1607 mL 26.3213 mL
5 mM 0.5264 mL 2.6321 mL 5.2643 mL
10 mM 0.2632 mL 1.3161 mL 2.6321 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.75 mg/mL (7.24 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.75 mg/mL (7.24 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.75 mg/mL (7.24 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

DibucaineCinchocaineSodium ChannelNa channelsNa+ channelsSChEBSA-goldInhibitorinhibitorinhibit

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Dibucaine hydrochloride
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HY-B0552A
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