LEP(116-130)(mouse)
Based on 1 publication(s) in Google Scholar
LEP(116-130)(mouse) is a synthetic leptin peptide fragment.
For research use only. We do not sell to patients.
- Purity: 99.19%
- CAS No.: 258276-95-8
- Formula: C64H109N19O24S
- Molecular Weight:1560.73
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Storage:
Sealed storage, away from moisture.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Protocol
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) LEP(116-130)(mouse)
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Biological Activity
LEP-(116-130) (300 μM) is unable to inhibit AP-OB binding[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 258276-95-8
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Appearance Solid
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Molecular Weight 1560.73
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Formula C64H109N19O24S
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Color White to off-white
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Sequence
Ser-Cys-Ser-Leu-Pro-Gln-Thr-Ser-Gly-Leu-Gln-Lys-Pro-Glu-Ser-NH2
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Sequence Shortening
SCSLPQTSGLQKPES-NH2
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Sealed storage, away from moisture
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (1)
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Journal Impact Factor
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Most Recent
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J Int Med Res
2020 Jun;48(6):300060520920062. PMID: 32529880
Solvent & Solubility
H2O : ≥ 100 mg/mL (64.07 mM)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
For the following dissolution methods, please prepare the working solution directly:
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: PBS
Solubility: 100 mg/mL (64.07 mM); Clear solution; Need ultrasonic
Protocol
Blood is drawn from the tail vein of each mouse 2 h before the onset of the dark period at the beginning of the study (day 0) and after 2, 4, and 6 days of treatment with 1 mg/day i.p. LEP-(116-130). Blood glucose levels are determined with a Glucometer Elite blood glucose monitor. After 4 and 7 days of treatment with 1 mg/day i.p. LEP-(116-130), sensitivity to cold is examined by placing the mice without food or water in a cold room with an ambient temperature of 4°C. Body temperature is measured with a rectal probe every hour for 4 h.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Purity & Documentation
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Data Sheet (276 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 0.6407 mL | 3.2036 mL | 6.4073 mL | 16.0181 mL |
| 5 mM | 0.1281 mL | 0.6407 mL | 1.2815 mL | 3.2036 mL | |
| 10 mM | 0.0641 mL | 0.3204 mL | 0.6407 mL | 1.6018 mL | |
| 15 mM | 0.0427 mL | 0.2136 mL | 0.4272 mL | 1.0679 mL | |
| 20 mM | 0.0320 mL | 0.1602 mL | 0.3204 mL | 0.8009 mL | |
| 25 mM | 0.0256 mL | 0.1281 mL | 0.2563 mL | 0.6407 mL | |
| 30 mM | 0.0214 mL | 0.1068 mL | 0.2136 mL | 0.5339 mL | |
| 40 mM | 0.0160 mL | 0.0801 mL | 0.1602 mL | 0.4005 mL | |
| 50 mM | 0.0128 mL | 0.0641 mL | 0.1281 mL | 0.3204 mL | |
| 60 mM | 0.0107 mL | 0.0534 mL | 0.1068 mL | 0.2670 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
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