MAFP
Based on 5 publication(s) in Google Scholar
MAFP (Methyl Arachidonyl Fluorophosphonate) is an selective, active-site directed and irreversible inhibitor of cPLA2 and iPLA2. MAFP is also a potent irreversible inhibitor of anandamide amidase.
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度 : 95.93%
- CAS 番号: 188404-10-6
- 分子式: C21H36FO2P
- 分子量:370.48
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保管条件:
-80°C, protect from light
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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MedChemExpress（MCE）の使用を引用している文献 MAFP
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生物活性
製品説明
IC50 & Target
体外実験
MAFP inhibits iPLA2, in a concentration-dependent manner with an IC50 of 0.5 μM after a 5 min preincubation at 40°C in P388D1 cells. cPLA, is a phospholipid hydrolase using the hydroxyl of serine-228 residue as its catalytic nucleophile[1]. MAFP is also an inhibitor of anandamide amidase and as a ligand for the CB1 cannabinoid receptor. MAFP demonstrates selectivity towards anandamide amidase for which it is approximately 3000 and 30000-fold more potent than it is towards chymotrypsin and trypsin, respectively. MAFP displaces [3H]CP-55940 binding to the CB1 cannabinoid receptor with an IC50 of 20 nM vs 40 nM for anandamide[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .
化学情報
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CAS 番号 188404-10-6
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性状 Liquid (Density: 0.960±0.06 g/cm3)
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分子量 370.48
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分子式 C21H36FO2P
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Color Colorless to light yellow
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SMILES
CCCCC/C=C\C/C=C\C/C=C\C/C=C\CCCCP(OC)(F)=O
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別名
Methyl Arachidonyl Fluorophosphonate
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輸送条件
Shipping with dry ice.
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保管条件
-80°C, protect from light
Publications (5)
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Journal Impact Factor
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Most Recent
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Cell
Cyclic-dinucleotide-induced filamentous assembly of phospholipases governs broad CBASS immunity. [Abstract]2025 Jul 10;188(14):3744-3756.e16. PMID: 40345202 -
Acta Pharm Sin B
Identification of a natural PLA2 inhibitor from the marine fungus Aspergillus sp. c1 for MAFLD treatment that suppressed lipotoxicity by inhibiting the IRE-1 α/XBP-1s axis and JNK signaling. [Abstract]2024 Jan;14(1):304-318. PMID: 38261820 -
Acta Physiol
2023 Apr;237(4):e13926. PMID: 36606511 -
J Biol Chem
Capsaicin inhibits intestinal Cl- secretion and promotes Na+ absorption by blocking TRPV4 channels in healthy and colitic mice. [Abstract]2022 May;298(5):101847. PMID: 35314195 -
Biochem Biophys Res Commun
Identification of a new autophagy inhibitor targeting lipid droplets in vascular endothelial cells. [Abstract]2021 Sep 24:571:195-200. PMID: 34330064
純度とドキュメンテーション
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データシート (266 KB)
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SDS (604 KB)
- English - EN (604 KB)
- Français - FR (604 KB)
- Deutsch - DE (604 KB)
- Norwegian - NO (604 KB)
- Español - ES (604 KB)
- Swedish - SV (604 KB)
- Italian - IT (604 KB)
- Korean - KR (604 KB)
- Portuguese - PT (604 KB)
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取扱説明書 (2659 KB)
参考文献
[1]. Lio YC, et al. Irreversible inhibition of Ca(2+)-independent phospholipase A2 by methyl arachidonyl fluorophosphonate. Biochim Biophys Acta. 1996 Jul 12;1302(1):55-60. [Content Brief]
[2]. Deutsch DG, et al. Methyl arachidonyl fluorophosphonate: a potent irreversible inhibitor of anandamide amidase. Biochem Pharmacol. 1997 Feb 7;53(3):255-60. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
MAFP 関連分類
HY-103334 関連分類
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