1. Membrane Transporter/Ion Channel
  2. Potassium Channel

MK-7145 

Cat. No.: HY-18277
Handling Instructions

MK-7145 is a ROMK inhibitor, with an IC50 of 0.045 μM.

For research use only. We do not sell to patients.

MK-7145 Chemical Structure

MK-7145 Chemical Structure

CAS No. : 1255204-84-2

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  • Biological Activity

  • Technical Information

  • Purity & Documentation

  • References

Description

MK-7145 is a ROMK inhibitor, with an IC50 of 0.045 μM.

IC50 & Target

IC50: 0.045 μM (ROMK)[1].

In Vitro

MK-7145 (Compound 12) is screened against other members of the Kir family of channels. It doed not show any significant activity on Kir2.1, Kir2.3, Kir4.1, or Kir7.1 channels when tested at concentrations up to 30 μM. MK-7145 is also selective against other cardiac ion channels such as Cav1.2 and Nav1.5 (IC50>30 μM). In a broad counterscreen panel conducted at Panlabs and including over 150 receptors, enzymes, and ion channels, MK-7145 only exhibits three activities at <10 μM: acetyl cholinesterase, ACES, IC50=9.94 μM, somatostatin subtype 1, sst1 IC50=2.63 μM, and human serotonin transporter, SERT, IC50=0.12 μM. In a functional assay using HEK293 cells stably transfected with human SERT, uptake of 3H-serotonin is inhibited by MK-7145 with an IC50 value of 2.40±0.32 μM (n=5). The superior ROMK potency and in vivo efficacy of MK-7145, coupled with the fact that MK-7145 is a substrate of human Pgp (human Mdr1 BAAB ratio=12), should be able to impart a significant safety window with respect to the SERT off-target activity.

Clinical Trial
Solvent & Solubility
In Vitro: 

10 mM in DMSO

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.1435 mL 10.7174 mL 21.4348 mL
5 mM 0.4287 mL 2.1435 mL 4.2870 mL
10 mM 0.2143 mL 1.0717 mL 2.1435 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

466.53

Formula

C₂₆H₃₀N₂O₆

CAS No.

1255204-84-2

SMILES

O[[email protected]](C1=C(C)C2=C(C(OC2)=O)C=C1)CN3CCN(C[[email protected]@H](C4=C(C)C5=C(C(OC5)=O)C=C4)O)CC3

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Shipping

Room temperature in continental US; may vary elsewhere

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Product Name:
MK-7145
Cat. No.:
HY-18277
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MK-7145

Cat. No.: HY-18277