1. Metabolic Enzyme/Protease
    NF-κB
  2. MALT1
  3. MLT-747

MLT-747 

Cat. No.: HY-124587
Handling Instructions

MLT-747 is a potent, selective, allosteric inhibitor of MALT1, binds MALT1 in the allosteric Trp580 pocket, with an IC50 of 14 nM.

For research use only. We do not sell to patients.

MLT-747 Chemical Structure

MLT-747 Chemical Structure

CAS No. : 2097853-86-4

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Description

MLT-747 is a potent, selective, allosteric inhibitor of MALT1, binds MALT1 in the allosteric Trp580 pocket, with an IC50 of 14 nM[1].

IC50 & Target

IC50: 14 nM (MALT1)[1]

In Vitro

MLT-747 (0-20 μM) stabilizes cellular MALT1-W580S with an EC50 of 314 nM[1].

Molecular Weight

478.33

Formula

C₂₀H₂₁Cl₂N₇O₃

CAS No.

2097853-86-4

SMILES

O=C(NC1=CC(Cl)=C(C(N2CCCC2)=O)N=C1)NC3=C([[email protected]@H](OC)C)N4C(N=C3)=CC(Cl)=N4

Shipping

Room temperature in continental US; may vary elsewhere

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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MLT-747
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