Meliaceae Extract

Toosendone (Compound 1) is a limonoid. Toosendone can be isolated from Melia toosendan.

Meliatoosenin I (Compound 287) is a Trichilin class limonoid. Meliatoosenin I can be isolated from Melia toosendan.

Meliatoosenin K is a trichilinin-type limonoid found in the fruits of Melia toosendan.

Neoazedarachin B is an insect antifeedant present in the root bark of Melia toosendan. Neoazedarachin B reduces the feeding behavior of third-instar larvae of Spodoptera littoralis.

Nimbolinin C is an insect antifeedant present in the unripe fruits of Melia toosendan. Nimbolinin C exhibits weak activity against the feeding behavior of third-instar larvae of Spodoptera exigua at a concentration of 1000 ppm.

Meliatoosenin P (Compound 12) is a limonoid found in the fruits of Melia toosendan.

Nimbolinin B is a limonoid found in the root bark of Turraea robusta.

Meliatoosenin N is a limonoid compound. Meliatoosenin N inhibits the replication of tobacco mosaic virus in vitro.

Nimbolidin B (Compound 4) is a tetranortriterpenoid compound. Nimbolidin B can be isolated from the fruits of Melia azedarach Linn.

Toosendanal is a limonoid compound present in the fruits of Melia toosendan Sieb. et al..

1-O-Tigloyl-1-O-debenzoylohchinal is an orally active limonoid-type triterpenoid anti-inflammatory and peripheral analgesic agent isolated from the fruits of Melia toosendan. 1-O-Tigloyl-1-O-debenzoylohchinal significantly inhibits acetic acid (HY-Y0319)-induced increase in vascular permeability, λ-Carrageenan (HY-N9470)-induced paw edema, and acetic acid-induced writhing response in mice. 1-O-Tigloyl-1-O-debenzoylohchinal shows no significant analgesic effect in the hot-plate test, and acts mainly on the peripheral rather than the central nervous system. 1-O-Tigloyl-1-O-debenzoylohchinal can be widely used in the research of acute or chronic inflammation, stomachache and other related diseases.

12-O-Ethyl-1-deacetylnimbolinin B (Compound 1) is a limonoid-type triterpenoid that can be found in the fruit of Melia toosendan Sieb. et Zucc.

1α,3α-Dihydroxyl-7α-tigloyloxy-12α-ethoxylnimbolinin is a nerve growth factor-enhanced limonoid. 1α,3α-Dihydroxyl-7α-tigloyloxy-12α-ethoxylnimbolinin enhances nerve growth factor-mediated neurite outgrowth in PC12 cells. 1α,3α-Dihydroxyl-7α-tigloyloxy-12α-ethoxylnimbolinin enhances nerve growth factor-mediated neurite outgrowth.

Trichilin K is a insect antifeeding iimonoid found in the stem bark of Melia toosendan. Trichilin K displays antifeedant activity against Spodoptera eridania larvae.

Dammarenolic Acid is a 3,4-secodammarane triterpene found in the wood of Cabralea eichleriana.

Toosenoside A (Compound 5) is a glycoside with a rare naturally occurring aglycone. Toosenoside A can be isolated from the fruits of Melia toosendan.

12β-1-O-Tigloyl-1-O-deacetyl-nimbolinin B (Compound 1b) is a nimbolinin-type limonoid found in the fruits of Melia toosendan.12β-1-O-Tigloyl-1-O-deacetyl-nimbolinin B exists as a tautomer of 12α-1-O-tigloyl-1-O-deacetyl-nimbolinin B.

12-O-Methylvolkensin is a limonoid found in the fruits of Melia toosendan Sieb. et Zucc. 12-O-Methylvolkensin shows cytotoxicity against cancer cells. 12-O-Methylvolkensin can be used for the research of cancer, such as human oral epidermoid carcinoma.

12-Ethoxynimbolinin E is a nimbolinin-type limonoid found in the fruits of Melia toosendan. 12-Ethoxynimbolinin E induces cytotoxic activity against cancer cells. 12-Ethoxynimbolinin E can be used for the research of cancer, such as myeloid leukemia, and lung cancer.

7-Oxogedunin (Compound 7DG; Compound 16) is a small molecule that protects macrophages from cell pyroptosis induced by anthrax lethal toxin (LT). Its target is protein kinase R (PKR). 7-Oxogedunin can widely inhibit the assembly of various inflammasomes (NLRP1 and NLRP3) and the activation of caspase-1 by inhibiting the kinase-independent function of PKR. 7-Oxogedunin has growth inhibitory activity on European corn borer larvae. 7-Oxogedunin can be used for LT toxicity inhibition and pest control research.