2. Metabolic Enzyme/Protease Anti-infection
  3. HIV Protease HIV
  4. Nelfinavir Mesylate

Nelfinavir Mesylate  (Synonyms: AG 1343 Mesylate)

製品番号: HY-15287A 純度: 98.93%
COA 取扱説明書

Nelfinavir Mesylate (AG 1343 Mesylate) is a potent and orally bioavailable HIV-1 protease inhibitor (Ki=2 nM) for HIV infection. Nelfinavir Mesylate (AG 1343 Mesylate) is a broad-spectrum, anticancer agent.

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Nelfinavir Mesylate 構造式

Nelfinavir Mesylate 構造式

CAS 番号 : 159989-65-8

容量 価格（税別） 在庫状況 数量
無料サンプル (0.1 - 0.5 mg)   今すぐ申し込む  
Solid + Solvent
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 88 在庫あり
Solution
10 mM * 1 mL in DMSO USD 88 在庫あり
Solid
5 mg USD 60 在庫あり
10 mg USD 90 在庫あり
25 mg USD 190 在庫あり
50 mg USD 320 在庫あり
100 mg   お問い合わせ  
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* アイテムを追加する前、数量をご選択ください

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カスタマーレビュー

Based on 13 publication(s) in Google Scholar

Other Forms of Nelfinavir Mesylate:

Nelfinavir Mesylate 関連抗体

Top Publications Citing Use of Products

    Nelfinavir Mesylate purchased from MedChemExpress. Usage Cited in: Cells. 2022, 11(22), 3580

    Nelfinavir Mesylate (5 µM; 24 h) suppresses expression of MITF in A2058 and A375 cells.

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    製品説明

    Nelfinavir Mesylate (AG 1343 Mesylate) is a potent and orally bioavailable HIV-1 protease inhibitor (Ki=2 nM) for HIV infection. Nelfinavir Mesylate (AG 1343 Mesylate) is a broad-spectrum, anticancer agent[1][2][3].

    IC50 & Target[1]

    HIV-1

     

    体外実験

    Nelfinavir (AG1341) Mesylate (1-10 μM; 48 hours) inhibits the proliferation of multiple myeloma cells[4].
    Nelfinavir Mesylate inhibits 26S chymotrypsin-like proteasome activity, impairs proliferation and triggers apoptosis of the myeloma cell lines and fresh plasma cells[4].
    Nelfinavir Mesylate (1-10 μM; 17 hours) induces apoptosis of multiple myeloma cell lines[4].
    Nelfinavir Mesylate (5 μM; 0-24 hours) decreases the phosphorylation of AKT[4].
    Nelfinavir Mesylate activates the cleavage of caspase-3, decreases the phosphorylation of AKT, STAT-3, ERK1/2, and activates the pro-apoptotic pathway of the unfolded protein response system[4].
    Nelfinavir is also a SARS-CoV 3CLpro inhibitor with an IC50 of 35.93 μM[5].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Nelfinavir Mesylate 関連抗体

    Cell Proliferation Assay[4]

    Cell Line: RPMI, LP1, U266, OPM2 and MM1S cells
    Concentration: 1, 2, 5, 10 μM
    Incubation Time: 48 hours
    Result: Inhibited the proliferation of RPMI, LP1, U266, OPM2 and MM1S cell lines in a dose-dependent manner with an IC50 of 1-5 μM.

    Apoptosis Analysis[4]

    Cell Line: LP1 and U266 cells
    Concentration: 1-10 μM
    Incubation Time: 17 hours
    Result: Induced a dose-dependent increase in the percentage of annexin V+/propidium iodide+ cells.

    Western Blot Analysis[4]

    Cell Line: U266 cells
    Concentration: 5 μM
    Incubation Time: 0-24 hours
    Result: The level of AKT phosphorylation in U266 cells decreased.
    体内実験

    Nelfinavir Mesylate (75 mg/kg; i.p.; 5 days a week for 21 days) decreases multiple myeloma cell growth in NOD/SCID mice[4].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: NOD/SCID mice (bearing U266-luc cells)[4]
    Dosage: 75 mg/kg
    Administration: I.p.; 5 days a week for 21 days
    Result: Decreased MM cell growth in NOD/SCID mice.
    臨床実験
    分子量

    663.89

    Appearance

    Solid

    分子式

    C33H49N3O7S2
    CAS 番号
    SMILES

    [H][C@]12C[C@@H](C(NC(C)(C)C)=O)N(C[C@H]([C@@H](NC(C3=C(C)C(O)=CC=C3)=O)CSC4=CC=CC=C4)O)C[C@@]1([H])CCCC2.CS(=O)(O)=O
    輸送条件

    Room temperature in continental US; may vary elsewhere.
    保管条件

    4°C, stored under nitrogen

    *In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
    溶剤 & 溶解度
    体外: 

    DMSO : 100 mg/mL (150.63 mM; Need ultrasonic)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 1.5063 mL 7.5314 mL 15.0627 mL
    5 mM 0.3013 mL 1.5063 mL 3.0125 mL
    10 mM 0.1506 mL 0.7531 mL 1.5063 mL
    *Please refer to the solubility information to select the appropriate solvent.
    体内:
    • 1.

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

      Solubility: ≥ 5 mg/mL (7.53 mM); Clear solution

    • 2.

      Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

      Solubility: ≥ 5 mg/mL (7.53 mM); Clear solution

    • 3.

      Add each solvent one by one:  10% DMSO    90% Corn Oil

      Solubility: ≥ 5 mg/mL (7.53 mM); Clear solution

    • 4.

      Add each solvent one by one:  5% DMSO    40% PEG300    5% Tween-80    50% Saline

      Solubility: ≥ 2.5 mg/mL (3.77 mM); Clear solution

    • 5.

      Add each solvent one by one:  5% DMSO    95% (20% SBE-β-CD in Saline)

      Solubility: ≥ 2.5 mg/mL (3.77 mM); Clear solution

    *All of the co-solvents are available by MedChemExpress (MCE).
    純度とドキュメンテーション

    純度: 98.93%

    COA (262 KB) LCMS (267 KB)

    取扱説明書 (2659 KB)
    参考文献
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    Nelfinavir Mesylate Related Classifications

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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    The dilution calculator equation

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
    × = ×
    C1   V1   C2   V2

    Keywords:

    Nelfinavir159989-65-8AG 1343AG1343AG-1343HIV ProteaseHIVHuman immunodeficiency virusproteaseproliferationmultiplemyelomacellsphosphorylationNOproductioninfectionInhibitorinhibitorinhibit

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