2. Metabolic Enzyme/Protease Autophagy Anti-infection
  3. HIF/HIF Prolyl-Hydroxylase Autophagy Virus Protease
  4. Oroxylin A

Oroxylin A  (Synonyms: Baicalein 6-methyl ether; 6-Methoxybaicalein; オロキシリンA)

製品番号: HY-N0560 純度: 99.74%
COA 取扱説明書 Technical Support

Oroxylin A is an active flavonoid compound with strong anti-cancer effects. Oroxylin A inhibits the IL-6/STAT3 pathway and NF-κB signaling, inhibits cell proliferation and induces apoptosis. Oroxylin A inhibits colitis-related carcinogenesis.

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Oroxylin A 構造式

Oroxylin A 構造式

CAS 番号 : 480-11-5

容量 価格（税別） 在庫状況 数量
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 294 在庫あり
Solution
10 mM * 1 mL in DMSO USD 294 在庫あり
Solid
1 mg USD 94 在庫あり
5 mg USD 198 在庫あり
10 mg USD 290 在庫あり
50 mg   お問い合わせ  
100 mg   お問い合わせ  

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Based on 11 publication(s) in Google Scholar

Other Forms of Oroxylin A:

Oroxylin A 関連抗体

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すべてのアイソフォームを表示
HIF-1α HIF

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製品説明

Oroxylin A is an active flavonoid compound with strong anti-cancer effects. Oroxylin A inhibits the IL-6/STAT3 pathway and NF-κB signaling, inhibits cell proliferation and induces apoptosis. Oroxylin A inhibits colitis-related carcinogenesis[1][2][3][4][5].

Cellular Effect
Cell Line Type Value Description References
HCT-116 IC50
33.9 μM
Compound: 1, Oroxylin A
Antiproliferative activity against human HCT116 cells after 48 hrs by MTT assay
Antiproliferative activity against human HCT116 cells after 48 hrs by MTT assay
[PMID: 22196122]
HepG2 IC50
22.7 μM
Compound: 1, Oroxylin A
Antiproliferative activity against human HepG2 cells after 48 hrs by MTT assay
Antiproliferative activity against human HepG2 cells after 48 hrs by MTT assay
[PMID: 22196122]
HUVEC IC50
61 μM
Compound: 5
Inhibition of trypsin-induced elevation in PAI1 production in HUVEC by ELISA
Inhibition of trypsin-induced elevation in PAI1 production in HUVEC by ELISA
[PMID: 9214730]
KB IC50
16.1 μM
Compound: O, oroxylin-A
Cytotoxicity against multi-drug resistant human KB cells overexpressing mdr1 after 3 days
Cytotoxicity against multi-drug resistant human KB cells overexpressing mdr1 after 3 days
[PMID: 18722769]
KB IC50
31.1 μM
Compound: O, oroxylin-A
Cytotoxicity against human KB cells after 3 days
Cytotoxicity against human KB cells after 3 days
[PMID: 18722769]
MV4-11 GI50
5.59 μM
Compound: 14, Oroxylin
Cytotoxicity against human MV4-11 cells harboring FLT3 mutation after 72 hrs by tetrazolium based Ez CyTox cell viability assay
Cytotoxicity against human MV4-11 cells harboring FLT3 mutation after 72 hrs by tetrazolium based Ez CyTox cell viability assay
[PMID: 23411073]
RS4-11 GI50
40 μM
Compound: 14, Oroxylin
Cytotoxicity against human RS4:11 cells harboring wild type FLT3 after 72 hrs by tetrazolium based Ez CyTox cell viability assay
Cytotoxicity against human RS4:11 cells harboring wild type FLT3 after 72 hrs by tetrazolium based Ez CyTox cell viability assay
[PMID: 23411073]
体外実験

Oroxylin A (20 μM; 24 h) inhibits the growth, proliferation, and migration of MDA-MB-231 cells. Oroxylin A also inhibits the invasion of MDA-MB-231 and inhibits its epithelial-to-mesenchymal transition (EMT) process[4].
Oroxylin A (20 μM; 24 h) also inhibits the expression of pro-inflammatory cytokines and inhibits the NF-κB signaling pathway[4].
The anti-inflammatory effect of Oroxylin A is abolished by TNF-α[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Oroxylin A 関連抗体
分子量

284.26

分子式

C16H12O5
CAS 番号
Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C1C=C(C2=CC=CC=C2)OC3=CC(O)=C(OC)C(O)=C13
Structure Classification
Initial Source
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
溶剤 & 溶解度
体外: 

DMSO : 62.5 mg/mL (219.87 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.5179 mL 17.5895 mL 35.1791 mL
5 mM 0.7036 mL 3.5179 mL 7.0358 mL
10 mM 0.3518 mL 1.7590 mL 3.5179 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

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In Vivo Dissolution Calculator
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純度とドキュメンテーション

純度: 99.87%

COA (250 KB) LCMS (265 KB)

取扱説明書 (2659 KB)
参考文献

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.5179 mL 17.5895 mL 35.1791 mL 87.9477 mL
5 mM 0.7036 mL 3.5179 mL 7.0358 mL 17.5895 mL
10 mM 0.3518 mL 1.7590 mL 3.5179 mL 8.7948 mL
15 mM 0.2345 mL 1.1726 mL 2.3453 mL 5.8632 mL
20 mM 0.1759 mL 0.8795 mL 1.7590 mL 4.3974 mL
25 mM 0.1407 mL 0.7036 mL 1.4072 mL 3.5179 mL
30 mM 0.1173 mL 0.5863 mL 1.1726 mL 2.9316 mL
40 mM 0.0879 mL 0.4397 mL 0.8795 mL 2.1987 mL
50 mM 0.0704 mL 0.3518 mL 0.7036 mL 1.7590 mL
60 mM 0.0586 mL 0.2932 mL 0.5863 mL 1.4658 mL
80 mM 0.0440 mL 0.2199 mL 0.4397 mL 1.0993 mL
100 mM 0.0352 mL 0.1759 mL 0.3518 mL 0.8795 mL
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Oroxylin A Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量   濃度   体積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Oroxylin A480-11-5Baicalein 6-methyl ether 6-MethoxybaicaleinHIF/HIF Prolyl-HydroxylaseAutophagyVirus ProteaseHypoxia-inducible factorsHIFsHIF-PHcolitis-associated cancerchemopreventioninflammationIL-6/STAT3 pathwayInhibitorinhibitorinhibit

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製品番号:
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