1. Metabolic Enzyme/Protease
    Autophagy
    Anti-infection
  2. HIF/HIF Prolyl-Hydroxylase
    Autophagy
    Virus Protease
  3. Oroxylin A

Oroxylin A (Synonyms: Baicalein 6-methyl ether; 6-Methoxybaicalein)

製品番号: HY-N0560 純度: 99.90%
取扱説明書

Oroxylin A is a natural active flavonoid with strong anticancer effects.

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Oroxylin A 構造式

Oroxylin A 構造式

CAS 番号 : 480-11-5

容量 価格(税別) 在庫状況 数量
10 mM * 1  mL in DMSO USD 198 在庫あり
Estimated Time of Arrival: December 31
5 mg USD 180 在庫あり
Estimated Time of Arrival: December 31
10 mg USD 264 在庫あり
Estimated Time of Arrival: December 31
50 mg   お問い合わせ  
100 mg   お問い合わせ  

* アイテムを追加する前、数量をご選択ください

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Based on 2 publication(s) in Google Scholar

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製品説明

Oroxylin A is a natural active flavonoid with strong anticancer effects. IC50 value: Target: In vitro: Oroxylin A suppressed the MDM2-mediated degradation of p53 via downregulating MDM2 transcription in wt-p53 cancer cells [1]. Oroxylin A remarkably reduced the generation of lactate and glucose uptake under hypoxia in HepG2 cells, inhibited HIF-1α expression and its stability [2]. Oroxylin A promotes superoxide dismutase (SOD2) gene expression through SIRT3-regulated DNA-binding activity of FOXO3a and increases the activity of SOD2 by promoting SIRT3-mediated deacetylation [3]. In vivo: Oroxylin A inhibited the tumor growth of nude mice-inoculated MCF-7 or HCT116 cells. The expression of MDM2 protein in tumor tissue was downregulated by oroxylin A as well [1].

分子量

284.26

分子式

C₁₆H₁₂O₅

CAS 番号

480-11-5

SMILES

O=C1C=C(C2=CC=CC=C2)OC3=CC(O)=C(OC)C(O)=C13

輸送条件

Room temperature in continental US; may vary elsewhere.

保管条件
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
溶剤 & 溶解度
体外: 

DMSO : ≥ 32 mg/mL (112.57 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.5179 mL 17.5895 mL 35.1791 mL
5 mM 0.7036 mL 3.5179 mL 7.0358 mL
10 mM 0.3518 mL 1.7590 mL 3.5179 mL
*Please refer to the solubility information to select the appropriate solvent.
体内:
  • 1.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (7.32 mM); Clear solution

*All of the co-solvents are provided by MCE.
参考文献

純度: 99.90%

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This equation is commonly abbreviated as: C1V1 = C2V2

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Keywords:

Oroxylin ABaicalein 6-methyl ether6-MethoxybaicaleinHIF/HIF Prolyl-HydroxylaseAutophagyVirus ProteaseHypoxia-inducible factorsHIFsHIF-PHInhibitorinhibitorinhibit

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製品名:
Oroxylin A
製品番号:
HY-N0560
数量:
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