Pratosartan (Synonyms: FW 7203; KD 3-671; KT 3671)

Cat. No.: HY-101574 Purity: 99.35%: Data Sheet
COA

SDS
Handling Instructions
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Pratosartan is a selective angiotensin II receptor antagonist.

For research use only. We do not sell to patients.

Pratosartan Chemical Structure

CAS No. : 153804-05-8

Size	Stock	Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	In-stock	Estimated Time of Arrival: December 31
Solid
1 mg	In-stock	Estimated Time of Arrival: December 31
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
25 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	Get quote
100 mg	Get quote

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Biological Activity
Purity & Documentation
References
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Description

Pratosartan is a selective angiotensin II receptor antagonist.

IC₅₀ & Target

angiotensin II receptor^[1]

In Vitro

Pratosartan, which is an orally active angiotensin II (AII) antagonist, exhibiting selective and potent antagonistic activity to AT₁ subtype^[1]. Pratosartan is a new angiotensin II type 1 receptor blocker. Pratosartan is an effective and well tolerated antihypertensive drug, and may has beneficial effect on hypertensive patients with some metabolic disorders^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

426.51

Formula

C₂₅H₂₆N₆O

CAS No.

153804-05-8

Appearance

Solid

Color

White to off-white

SMILES

O=C1CCCCC2=C1N(CC3=CC=C(C4=CC=CC=C4C5=NN=NN5)C=C3)C(CCC)=N2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (234.46 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.3446 mL	11.7231 mL	23.4461 mL
5 mM	0.4689 mL	2.3446 mL	4.6892 mL
10 mM	0.2345 mL	1.1723 mL	2.3446 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.35%

Select Batch:

Data Sheet (276 KB) SDS (254 KB)

COA (256 KB) HNMR (289 KB) LCMS (103 KB)

Handling Instructions (2659 KB)

References

[1]. Sonegawa M, et al. Synthesis and pharmacological activity of the metabolites of Pratosartan. Chem Pharm Bull (Tokyo). 2006 Jun;54(6):782-7. [Content Brief]

[2]. Ogihara T, et al. Clinical efficacy of a new angiotensin II type 1 receptor blocker, pratosartan, in hypertensive patients. Hypertens Res. 2008 Feb;31(2):281-7. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.3446 mL	11.7231 mL	23.4461 mL	58.6153 mL
	5 mM	0.4689 mL	2.3446 mL	4.6892 mL	11.7231 mL
	10 mM	0.2345 mL	1.1723 mL	2.3446 mL	5.8615 mL
	15 mM	0.1563 mL	0.7815 mL	1.5631 mL	3.9077 mL
	20 mM	0.1172 mL	0.5862 mL	1.1723 mL	2.9308 mL
	25 mM	0.0938 mL	0.4689 mL	0.9378 mL	2.3446 mL
	30 mM	0.0782 mL	0.3908 mL	0.7815 mL	1.9538 mL
	40 mM	0.0586 mL	0.2931 mL	0.5862 mL	1.4654 mL
	50 mM	0.0469 mL	0.2345 mL	0.4689 mL	1.1723 mL
	60 mM	0.0391 mL	0.1954 mL	0.3908 mL	0.9769 mL
	80 mM	0.0293 mL	0.1465 mL	0.2931 mL	0.7327 mL
	100 mM	0.0234 mL	0.1172 mL	0.2345 mL	0.5862 mL

Pratosartan Related Classifications

Endocrinology Cardiovascular Disease

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Pratosartan153804-05-8FW 7203 KD 3-671 KT 3671FW7203FW-7203KT3671KT 3671KT-3671Angiotensin ReceptorInhibitorinhibitorinhibit

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