Rat CGRP-(8-37)
Based on 9 publication(s) in Google Scholar
Rat CGRP-(8-37) (VTHRLAGLLSRSGGVVKDNFVPTNVGSEAF) is a highly selective CGRP receptor antagonist.
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度 : 99.89%
- CAS 番号: 129121-73-9
- 分子式: C138H224N42O41
- 分子量:3127.51
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保管条件:
Sealed storage, away from moisture and light.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- プロトコル
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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HY-P0203
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MedChemExpress（MCE）の使用を引用している文献 Rat CGRP-(8-37)
More- Nat Commun. 2026 Mar 19. [Abstract]
- J Neuroinflammation. 2021 May 21;18(1):117. [Abstract]
- J Headache Pain. 2022 Dec 12;23(1):157. [Abstract]
- J Invest Dermatol. 2022 Aug;142(8):2173-2183.e6. [Abstract]
- CNS Neurosci Ther. 2021 Nov;27(11):1409-1424. [Abstract]
- Int Immunopharmacol. 2023 Mar:116:109747. [Abstract]
- Front Pharmacol. 2022 Mar 8;13:835187. [Abstract]
- Sci Rep. 2025 Feb 25;15(1):6686. [Abstract]
- Korean J Pain. 2026 Jan 1;39(1):86-95. [Abstract]
Customer Validation & Images
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Flow Cytometry
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Histological Imaging/Staining
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Flow Cytometry
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Others
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WB
生物活性
製品説明
IC50 & Target
CGRP receptor[1]
体外実験
CGRP-(8-37) is a truncated version of calcitonin gene-related peptide (CGRP) that binds to the CGRP receptor with similar affinity but does not activate the receptor[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
体内実験
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 129121-73-9
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性状 Solid
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分子量 3127.51
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分子式 C138H224N42O41
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Color White to off-white
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配列
Val-Thr-His-Arg-Leu-Ala-Gly-Leu-Leu-Ser-Arg-Ser-Gly-Gly-Val-Val-Lys-Asp-Asn-Phe-Val-Pro-Thr-Asn-Val-Gly-Ser-Glu-Ala-Phe-NH2
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シーケンスの短縮
VTHRLAGLLSRSGGVVKDNFVPTNVGSEAF-NH2
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Sealed storage, away from moisture and light
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Publications (9)
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Journal Impact Factor
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Most Recent
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Nat Commun
Low-intensity focused ultrasound-activated piezoelectric gel bandage for diabetic wound repair and neuropathic pain relief. [Abstract]2026 Mar 19. PMID: 41857055
Rat CGRP-(8-37) purchased from MedChemExpress. Usage Cited in: Nat Commun. 2026 Mar 19. [Abstract]
Flow cytometry analysis and relative quantification of macrophage polarization after different treatments (n = 3 biologically independent samples). G1, control; G2, BT-dNO@Gel+LIFU; G3, BT-dNO@Gel+LIFU + CGRP8-37.
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J Neuroinflammation
Calcitonin gene-related peptide regulates spinal microglial activation through the histone H3 lysine 27 trimethylation via enhancer of zeste homolog-2 in rats with neuropathic pain. [Abstract]2021 May 21;18(1):117. PMID: 34020664
Rat CGRP-(8-37) purchased from MedChemExpress. Usage Cited in: J Neuroinflammation. 2021 May 21;18(1):117. [Abstract]
The mechanical withdrawal threshold (MWT) and thermal withdrawal latency (TWL) of rats treated with intrathecal injection of 1 μM CGRP, 5 nM GSK126, 2 μM CGRP8-37 or solvent (dissolved in 10 L solution) daily for 9 days were measured during a 10-day observation period.
Rat CGRP-(8-37) purchased from MedChemExpress. Usage Cited in: J Neuroinflammation. 2021 May 21;18(1):117. [Abstract]
Western blot analysis of EZH2 and H3K27me3 protein levels in the dorsal horn of the spinal cord at 3 days post-CCI surgery. Data were obtained from the dorsal horn of the spinal cord of animals treated daily with 1 μM CGRP, 5 nM GSK126, 2 μM CGRP8-37, or a solvent control (10 L solution) for 2 days.
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J Headache Pain
CGRP-dependent sensitization of PKC-δ positive neurons in central amygdala mediates chronic migraine. [Abstract]2022 Dec 12;23(1):157. PMID: 36510143 -
J Invest Dermatol
Lidocaine Ameliorates Psoriasis by Obstructing Pathogenic CGRP Signaling‒Mediated Sensory Neuron‒Dendritic Cell Communication. [Abstract]2022 Aug;142(8):2173-2183.e6. PMID: 35032503
Rat CGRP-(8-37) purchased from MedChemExpress. Usage Cited in: J Invest Dermatol. 2022 Aug;142(8):2173-2183.e6. [Abstract]
Representative H&E staining images of IMQ mouse skin treated with PBS or Rat CGRP-(8-37) (10 μg).
Rat CGRP-(8-37) purchased from MedChemExpress. Usage Cited in: J Invest Dermatol. 2022 Aug;142(8):2173-2183.e6. [Abstract]
Flow cytometry was used to analyze the expression of IL-23⁺BMDC in DRG-BMDC cocultures treated with PBS and 0.05 mM LIDO and/or Rat CGRP-(8-37) (10 μM).
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CNS Neurosci Ther
Calcitonin gene-related peptide induces the histone H3 lysine 9 acetylation in astrocytes associated with neuroinflammation in rats with neuropathic pain. [Abstract]2021 Nov;27(11):1409-1424. PMID: 34397151 -
Int Immunopharmacol
Calcitonin gene-related peptide ameliorates sepsis-induced intestinal injury by suppressing NLRP3 inflammasome activation. [Abstract]2023 Mar:116:109747. PMID: 36706592 -
Front Pharmacol
Effect of Xiongmatang Extract on Behavioral and TRPV1-CGRP/CGRP-R Pathway in Rats With Migraine. [Abstract]2022 Mar 8;13:835187. PMID: 35350752 -
Sci Rep
Mechanism of calcitonin gene related peptide against acute pancreatitis in rats by modulating amino acid metabolism based on metabonomics. [Abstract]2025 Feb 25;15(1):6686. PMID: 39994332 -
Korean J Pain
Pulsed radiofrequency attenuates mechanical hypersensitivity in neuropathic pain rats by activating the Nrf2-regulated CaMKII/NF-κB signaling pathway. [Abstract]2026 Jan 1;39(1):86-95. PMID: 41469215
溶剤 & 溶解度
体外:
H2O : 25 mg/mL (7.99 mM; Need ultrasonic)
DMSO : 1.25 mg/mL (0.40 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
プロトコル
Animal Administration[1]
Rats: Adult male Sprague Dawley rats are given a spinal hemisection or a sham surgery at the T13 spinal segment. An externally accessible PE-10 intrathecal catheter that terminated at T13 is used for drug delivery. Animals are allowed to recover for 4 weeks at which time the hemisected animals displayed mechanical and thermal allodynia bilaterally, in both forelimbs and hindlimbs. CGRP-(8-37) is delivered just prior to a testing session in 1, 5, 10, or 50 nM doses in artificial cerebral spinal fluid in 10 mL volumes[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
純度とドキュメンテーション
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データシート (284 KB)
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SDS (254 KB)
- English - EN (254 KB)
- Français - FR (254 KB)
- Deutsch - DE (254 KB)
- Norwegian - NO (254 KB)
- Español - ES (254 KB)
- Swedish - SV (254 KB)
- Italian - IT (254 KB)
- Korean - KR (254 KB)
- Portuguese - PT (254 KB)
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取扱説明書 (2659 KB)
参考文献
[1]. Bennett AD, et al. Alleviation of mechanical and thermal allodynia by CGRP(8-37) in a rodent model of chroniccentral pain. Pain. 2000 May;86(1-2):163-75. [Content Brief]
[2]. Yu LC, et al. The calcitonin gene-related peptide antagonist CGRP8-37 increases the latency to withdrawalresponses in rats. Brain Res. 1994 Aug 8;653(1-2):223-30. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 0.3197 mL | 1.5987 mL | 3.1974 mL | 7.9936 mL |
| 5 mM | 0.0639 mL | 0.3197 mL | 0.6395 mL | 1.5987 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Rat CGRP-(8-37) 関連分類
HY-P0209 関連分類
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