Infection

Antibacterial agent 42, an antibacterial agent, significantly lowers MIC value of antibacterial agent Ceftazidime.

Mupirocin (BRL-4910A, Pseudomonic acid) calcium is an orally active antibiotic isolated from Pseudomonas fluorescens. Mupirocin calcium apparently exerts its antimicrobial activity by reversibly inhibiting isoleucyl-transfer RNA, thereby inhibiting bacterial protein and RNA synthesis.

Aurein 3.2 is an antibiotic antimicrobial peptide. Aurein 3.2 also has anticancer activity.

Virgilagicin is a Gram-positive active antibiotic that has a dual polyprenyl phosphate binding mechanism that impedes resistance development.

Myrrhterpenoid O (Compound 18) is a sesquiterpenoid compound that exhibits good inhibitory activity against Plasmodium falciparum (IC₅₀ = 21 μM).

PROTAC ACC degrader-1 is an Acetyl-CoA Carboxylase PROTAC degrader with insecticidal activity, which induces ACC protein degradation via the ubiquitin-proteasome system. PROTAC ACC degrader-1 exhibits significant dose-dependent insecticidal activity against Aphis craccivora nymphs. PROTAC ACC degrader-1 can be used in studies related to Aphis craccivora infestation.

PXYD3 is a ribosomal protein S1 (RpsA) antagonist with K_ds of 5.66 and 6.91 μM for RpsA-CTD and RpsA-CTD Δ438A, respectively. RpsA plays an important role in the trans-translation process of Mycobacterium Tuberculosis (Mtb).

Erythrinin A is an antibacterial agent belonging to the class of prenylated isoflavonoids. Erythrinin A can be used for research on bacterial infections.

Coccinin is an antifungal peptide. Coccinin can be purified from the seeds of large scarlet runner beans. Coccinin inhibits HIV-1 reverse transcriptase. Coccinin shows antifungal activity against M. arachidicola, F. oxysporum, P. piricola, B. cinerea, C. comatus and R. solani, with IC₅₀s of 75, 81, 89, 109, 122 and 134 μM, respectively.

Niruriside is a HIV REV/RRE complex inhibitor. Niruriside specifically inhibits the binding interaction between HIV REV protein and RRE RNA, with an IC₅₀ of 3.3 μM, and shows no significant activity against the unrelated R17 capsid protein/operator RNA binding system. At the tested concentrations, Niruriside fails to protect CEM-SS cells from acute HIV-1 infection. Niruriside can be used in the research of human immunodeficiency virus (HIV) infection.

Gatifloxacin-d₃ (hydrochloride) is the deuterium labeled Gatifloxacin (hydrochloride). Gatifloxacin hydrochloride (AM-1155; BMS-206584; PD135432) is a potent fluoroquinolone antibiotic with broad-spectrum antibacterial activity. Gatifloxacin hydrochloride inhibits bacterial type II topoisomerases (IC50=13.8 μg/ml for S. aureus topoisomerase IV) and E. coli DNA gyrase (IC50 = 0.109 μg/ml). Gatifloxacin hydrochloride can be used to treat bacterial conjunctivitis in vivo.

Acetylseneciphylline N-oxide is a pyrrolizine alkaloid that is seneciphylline in which the hydroxy hydrogen is replaced by an acetyl group and the tertiary amino function is oxidised to the corresponding N-oxide.

Brevicompanine B, a diketopiperazine alkaloid, is an antiplasmodial agent. Brevicompanine B is active against the malaria parasite Plasmodium falciparum 3D7 IC₅₀ of 35 mg/mL.

Clerocidin dimer is a dimeric clerodane derivative antibiotic that can be found in fermentations of the fungus Oidiodendron truncatum. Clerocidin dimer exhibits antibiotic activity.

Taxus cuspidata extract is an extract of the yew tree (Taxus cuspidata) that has antibacterial, antioxidant, anticancer, and anti-aging properties.

Iodopropynyl butylcarbamate-d₉ (IPBC-d₉) is the deuterated-labeled Iodopropynyl butylcarbamate (HY-W009335). Iodopropynyl butylcarbamate (IPBC) is a broad-spectrum antibacterial agent. Iodopropynyl butylcarbamate disrupts bacterial membranes and inhibits V. parahaemolyticus and S. aureus biofilms. Iodopropynyl butylcarbamate exhibits antimold activity and displays broad-spectrum antifungal/antialgal activity involving iodine-thiol protein disruption. Iodopropynyl butylcarbamate can be used in research related to bacterial and fungal infections.

N-Acetyldemethylphosphinothricin tripeptide, a peptide antibiotic, is a compound with herbicidal activity. N-Acetyldemethylphosphinothricin tripeptide consists of the unusual amino acid phosphinothricin (PT) and two alanine residues. N-Acetyldemethylphosphinothricin tripeptide penetrates bacterial cells as a prodrug via peptide uptake systems with subsequent release of PT.

Herquline A (Herqueline A) is a fungal piperazine alkaloid. Herquline A is a fungal metabolite that inhibits platelet aggregation and replication of the influenza virus.

ELQ-650 is a quinolone derivative, that exhibits antimicrobial activity against several protozoan parasites, including the intraerythrocytic parasites Plasmodium and Babesia. ELQ-650 attenuates babesiosis in immunosuppressed mice.

α-Rubromycin (Collinomycin) is an antibiotic isolated from the mycelia of Streptomyces collinus. α-Rubromycin also acts as a DNA polymerase inhibitor, with an IC₅₀ of 0.91 μM against bovine mammalian DNA polymerase. α-Rubromycin binds to the active region of DNA polymerase β, competes with nucleotide substrates for binding, and interferes with template-DNA interactions. α-Rubromycin inhibits the activities of telomerase, retroviral reverse transcriptase and terminal deoxynucleotidyl transferase, as well as the growth of Staphylococcus aureus. α-Rubromycin can be used in studies related to bacterial infections.