Infection

Ro 19-9638 is the major metabolite of Ro 15-0216. Ro 19-9638 exhibits antiparasitic efficacy against Trypanosoma brucei rhodesiense with an IC₅₀ of 0.0341 µg/mL.

DHFR-IN-16 (compound 8d) is an inhibitor of dihydrofolate reductase (DHFR) (IC₅₀=0.199 μM) and can be used in anti-infectious research.

Gallium hematoporphyrin is a heme analogue and a selective targeting agent against Mycobacteroides abscessus. Gallium hematoporphyrin induces ROS production and inhibits biofilm formation as well as disrupts preformed biofilms in both smooth and rough colony morphotypes of Mycobacteroides abscessus. Gallium hematoporphyrin interferes with heme-dependent metabolic pathways and suppresses the growth of clinical Mycobacteroides abscessus isolatess, with MICs ranging from 0.5 to 1 μg/ml. Gallium hematoporphyrin exhibits synergistic antibacterial activity with Clarithromycin (HY-17508) against Mycobacteroides abscessus. Gallium hematoporphyrin can be used for the research of Mycobacteroides abscessus infection.

MMV390048 (Standard) is the analytical standard of MMV390048 (HY-106005). This product is intended for research and analytical applications. MMV390048 is a representative of a new chemical class of Plasmodium PI4K inhibitor (Kdapp=0.3 μM). MMV390048 binds to the ATP binding site of Plasmodium PI4K and does not bind to other P. falciparum and human kinases apart from human PIP4K2C, thus alleviating potential kinase-mediated safety concerns. MMV390048 is an antimalarial agent.

Mafenide propionate is a dual inhibitor of dihydropteroate synthase (Dihydropteroate synthase) and carbonic anhydrase (Carbonic anhydrase). Mafenide propionate disrupts nucleotide biosynthesis by inhibiting the de novo base synthesis pathway, thereby exerting broad-spectrum antibacterial and cytotoxic effects without inducing mutations. Mafenide propionate can be used for wound assessment and promotes the formation of healthy granulation tissue, making it suitable for scenarios such as mesh skin grafting. Mafenide propionate has been widely used in studies on diseases associated with burn wound infections, acute and chronic wounds, blast injuries, open fractures, and necrotizing fasciitis.

FtsZ-IN-15 is an inhibitor targeting the FtsZ protein of Xanthomonas oryzae pv. oryzae (Xoo) and a cell division inhibitor. FtsZ-IN-15 specifically binds to key residues of XooFtsZ, inhibits its GTPase activity and disrupts its polymerization. FtsZ-IN-15 induces cell elongation of Xanthomonas oryzae pv. oryzae and exhibits significant antibacterial activity against this strain. FtsZ-IN-15 shows good control efficacy against rice bacterial blight and can be used in relevant research on rice bacterial blight.

Glidobactin F is an anti-tumor antibiotic. Glidobactin F has the activity against pathogenic fungi and yeast. Glidobactin F also extends the survival of mice inoculated with leukemia P388 cells.

Pradimicin B is an antibiotic. Pradimicin B has strong antifungal and yeast activity.

4-Isopropyl-3-methylphenol acts as a biofilm inhibitor, Antibacterial agent, Antifungal agent, and Acaricide. 4-Isopropyl-3-methylphenol reduces the expression levels of biofilm-associated gtfB, gtfD, and gtfC genes. 4-Isopropyl-3-methylphenol disrupts ion and redox homeostasis in fungal cells, and its combination with Octylgallate enhances antifungal activity. 4-Isopropyl-3-methylphenol exhibits fumigant toxicity and direct contact toxicity against Dermatophagoides farinae and Dermatophagoides pteronyssinus. 4-Isopropyl-3-methylphenol is applicable to research related to dental caries and Aspergillus infections/contamination.

CYP51-IN-2 (compound 1g), a Fluconazole (HY-B0101) analog, is a potent antifungal agent. CYP51-IN-2 shows MIC₈₀s of 62.5 and 250 ng/mL for Microsporum gypseum and Candida albicans, respectively.

Omeprazole sulfone N-Oxide is an Omeprazole (HY-B0113) analog with binding affinity to Nilaparvata lugens choline acetyltransferase (ChAT).

Antifungal agent 89 (compound 28) is a antifungal agent against Cryptococcus neoformans with minimum inhibitory concentration value ranging from 0.8 to 52.17 μM.

MDOLL-0229 (compound 27) is an antiviral agent that targets SARS-CoV-2 Mac1 and repress coronavirus replication. MDOLL-0229 inhibits SARS-CoV-2 Mac1 with an IC₅₀ of 2.1 µM.

BDM31827 is an EthR inhibitor. BDM31827 can be used for multidrug-resistant-tuberculosis research.

Flutrimazole (Standard) is the analytical standard of Flutrimazole. This product is intended for research and analytical applications. Flutrimazole is an imidazole antifungal with dual anti-inflammatory and antifungal activity. Flutrimazole shows scarce transdermal penetration. Flutrimazole has the advantageous in the research of topical fungal infections with an inflammatory component.

LEDGIN6 (Standard) is the analytical standard of LEDGIN6 (HY-10522). This product is intended for research and analytical applications. LEDGIN6 (CX05168) is a quinoline-based protein-protein interaction inhibitor of LEDGF/p75 and HIV integrase.

ML189 is an HSP90 inhibitor. ML189 can be used in the research of infectious diseases such as candidiasis.

Fumaryl-DL-alanine has anti-Gram-positive bacterial activity.

Zifanocycline (TFA) (Standard) is the analytical standard of Zifanocycline (TFA). This product is intended for research and analytical applications. Zifanocycline (KBP-7072) TFA is an orally active, semi-synthetic aminomethylcycline antibiotic that inhibits the normal function of bacterial ribosomes. Zifanocycline TFA has broad spectrum in vitro antimicrobial activity against Gram-positive and Gram-negative bacteria, including many multidrug-resistant pathogens. Zifanocycline TFA is indicated for the study of acute bacterial skin and skin structure infections, community-acquired bacterial pneumonia, and complicated intra-abdominal infections[1][2].

Quercetin 3-O-(2G-β-D-xylopyranosylrutinoside) is an oviposition inhibitory factor. Quercetin 3-O-(2G-β-D-xylopyranosylrutinoside) can be isolated from the leaves of Orixa japonica. When presented together with the oviposition stimulant from Citrus unshiu (Satsuma mandarin), Quercetin 3-O-(2G-β-D-xylopyranosylrutinoside) inhibits oviposition by gravid female Papilio xuthus (Asian swallowtail).