Infection

S-Hydroprene is an insecticide. S-Hydroprene prolongs larval and pupa durations, disrupts larval development, suppresses pupation, and exhibits larvicidal activity against Culex quinquefasciatus and Blatta orientalis.

Florpyrauxifen-benzyl is an auxin herbicide. Florpyrauxifen-benzyl is promising for research of agricultural weeds, such as Echinochloa crusgalli in rice paddies.

Miyakamide B1 is an antibiotic with insecticidal effect. Miyakamide B1 inhibits the growth of Artemia salina. Miyakamide B1 has a weak antixanthomonas activity. Miyakamide B1 inhibits P388 cells with an IC₅₀ of 8.8 μg/mL.

(S)-IB-96212 (compound 4), an oligomycin derivative, inhibits the MurD2 reaction, but not the MurL reaction. (S)-IB-96212 is a specific inhibitor of the alternative pathway of peptidoglycan biosynthesis. (S)-IB-96212 weakly inhibits the MurD reaction.

2-Hydroxypalmitic acid-d₃₀ (2-Hydroxyhexadecanoic acid-d₃₀) is the d₃₀ labeled 2-Hydroxypalmitic acid (HY-N7814). 2-Hydroxypalmitic acid is an intermediate in the phytosphingosine metabolic pathway. 2-Hydroxypalmitic acid is exclusively incorporated into sphingolipids and not used for other lipids. 2-Hydroxypalmitic acid promotes the production of odd-carbon phosphatidylcholine species. 2-Hydroxypalmitic acid is applicable to studies of Saccharomyces cerevisiae infection.

Juvenimicin A2 can resist Gram-positive bacteria and individual Gram-negative bacteria.

Pazufloxacin (mesylate) (Standard) is the analytical standard of Pazufloxacin mesylate (HY-B0724A). This product is intended for research and analytical applications. Pazufloxacin mesylate is an orally active fluoroquinolone antimicrobial agent. Pazufloxacin mesylate inhibits DNA gyrase with IC₅₀ values of 0.88 μg/mL (E. coli) and 1.9 μg/mL (P. aeruginosa). Pazufloxacin mesylate exhibits broad-spectrum antimicrobial activity, with MIC₉₀ values ranging from 0.025 to 100 μg/mL against Gram-positive and Gram-negative bacteria, non-fermenting bacteria, Legionella spp., and anaerobic bacteria. Pazufloxacin mesylate is indicated for research on systemic infections, lung infections, urinary tract infections, and Legionella pneumonia.

Pyrrolomycin B is a pyrrole antibiotic. Pyrrolomycin B has anti-Gram-positive bacteria, anti-Gram-negative bacteria and anti-individual fungi activity.

CYP51-IN-27 is a sterol 14α-demethylase CYP51 inhibitor with an IC₅₀ of 0.3434 μg/mL. CYP51-IN-27 exhibits antifungal activity and inhibits the production of fungal ergosterol. CYP51-IN-27 can be used for the research of infection, such as rice sheath blight.

JH-X-119-01 (Standard) is the analytical standard of JH-X-119-01 (HY-103017A). This product is intended for research and analytical applications. JH-X-119-01 is a potent and selective interleukin-1 receptor-associated kinases 1 (IRAK1) inhibitor. JH-X-119-01 ameliorates LPS-induced sepsis in mice. JH-X-119-01 inhibits IRAK1 biochemically with an apparent IC₅₀ of 9 nM while exhibiting no inhibition of IRAK4 at concentrations up to 10 μM.

MI-23 is a SARS-CoV-2 main protease (SARS-CoV-2 M_pro) inhibitor with an IC₅₀ of 7.6 nM. MI-23 is applicable to the research of COVID-19.

NMT-IN-9 is an arylpyrrolidone-based NMT inhibitor with an IC₅₀ of 93.20 nM and a K_D of 5.57 × 10^-9 M against NMT. NMT-IN-9 exhibits broad-spectrum antifungal activity against Candida albicans, Candida glabrata, Candida tropicalis, Cryptococcus neoformans and Aspergillus fumigatus, with an MIC of 2-16 μg/mL, and retains activity against fluconazole-resistant Candida isolates, with an MIC of 8-16 μg/mL. NMT-IN-9 induces intracellular ROS accumulation, mitochondrial membrane depolarization, DNA damage, apoptosis and necrotic cell death in fungal cells, and disrupts fungal cell integrity. NMT-IN-9 can be used for studies on NMT-targeted antifungal mechanisms and fluconazole-resistant Candida infections.

Mniopetal E is a reverse transcriptase inhibitor found in Mniopetalum sp. 87256.

GAP-1173149 is a Chikungunya Virus polymerase inhibitor targeting the CHIKV nsP4 RNA-dependent RNA polymerase.

Fujianmycin A has anti-subtilis activity.

Penfluron is an insect-growth regulator with chitin-inhibiting activities. Penfluron inhibits the total haemocyte count (THC) of Dysdercus koenigii.

Cbz-​Valaciclovir (Standard) is the analytical standard of Cbz-​Valaciclovir. This product is intended for research and analytical applications. Cbz-Valaciclovir (Benzyloxycarbonyl valacyclovir) can be used to prepare Valaciclovir (HY-17425) and for antiviral research.

nAChR modulator-3 (Compound II-08) is a Mpα1/ratβ2 binder (EC₅₀: 0.111 μM) and Mpα1/ratβ2 modulator. nAChR modulator-3 exhibits aphicidal activity and Mpα1/ratβ2 sensibility. nAChR modulator-3 exhibits a certain control efficacy against M. persicae.

Pyrocoll is a bacterial metabolite originally isolated from Streptomyces. It inhibits the growth of A. aurescens, A. globiformis, A. oxydans, A. pascens, and R. erythropolis bacteria (MICs=10, 1, 10, 3, and 10 μg/mL, respectively) and HMO2, HepG2, and MCF-7 cancer cells (GI₅₀s=0.28, 0.42, and 2.2 μg/mL, respectively) in vitro. Pyrocoll is also active against P. falciparum and T. rhodesiense (IC₅₀s=1.19 and 1.97 μg/mL, respectively).

Sannamycin C is an aminoglycoside antibiotic. Sannamycin C has weak antibacterial activity against Gram-positive bacteria.