GAP-1173149
GAP-1173149 is a Chikungunya Virus polymerase inhibitor targeting the CHIKV nsP4 RNA-dependent RNA polymerase.
For research use only. We do not sell to patients.
- CAS No.: 1622645-58-2
- Formula: C14H19N5O3
- Molecular Weight:305.33
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
GAP-1173149 shows EC50 values of 15.6, 18.6, 5.3 and 11.62 μM in U-2 OS cells, Vero cells, CHIKV replicon and normal human dermal fibroblasts[1].
GAP-1173149 shows CC50 values >100 μM in U-2 OS and Vero cells, and >500 μM in normal human dermal fibroblasts[1].
GAP-1173149 (100 μM) exhibits alphavirus-specific activity, inhibiting RNA replication of CHIKV, o’nyong-nyong virus (ONNV), Ross River virus (RRV), Eastern equine encephalitis virus (EEEV) and Barmah Forest virus (BFV), while showing no inhibition on unrelated viruses (HPIV3, RSV, SARS-CoV-2, VSV) or Sindbis virus (SINV)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 1622645-58-2
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Molecular Weight 305.33
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Formula C14H19N5O3
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SMILES
O=C(NCC1=NNC2=C1CCCCC2)CN(C(NC3)=O)C3=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
GAP-1173149 Related Classifications
HY-178334 Related Classifications
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