1. GPCR/G Protein
    Neuronal Signaling
  2. Neurokinin Receptor

Substance P 7-11 

Cat. No.: HY-P1492
Handling Instructions

Substance P (7-11) is a C-terminal fragment of Substance P which can cause an increase in the intracellular calcium concentration. Sequence: Phe-Phe-Gly-Leu-Met-NH2;FFGLM-NH2.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

Substance P 7-11 Chemical Structure

Substance P 7-11 Chemical Structure

CAS No. : 51165-05-0

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25 mg USD 280 Get quote

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Customer Review

  • Biological Activity

  • Protocol

  • Technical Information

  • Purity & Documentation

  • References

Description

Substance P (7-11) is a C-terminal fragment of Substance P which can cause an increase in the intracellular calcium concentration. Sequence: Phe-Phe-Gly-Leu-Met-NH2;FFGLM-NH2.

In Vitro

Substance P (7-11) increases PGE2 and collagenase production at concentrations greater than 1 μM. Substance P (7-11), but not intact SP, SP-(1-4), SP-(1-6), SP- (8-11) or SP-(9-1 1), nor the tachykinins NKA and NKB, causes an increase in the intracellular calcium concentration as measured by the fluorescent dye Fura-2. The maximal change in intracellular calcium induced by 10 μM Substance P (7-11) was 140±30 nM[1].

Solvent & Solubility
In Vitro: 

10 mM in H2O

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.6319 mL 8.1595 mL 16.3191 mL
5 mM 0.3264 mL 1.6319 mL 3.2638 mL
10 mM 0.1632 mL 0.8160 mL 1.6319 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Cell Assay
[1]

Confluent chondrocytes are incubated for 24 h with SP or Substance P (7-11). TIMP activity is inactivated following reduction and alkylation with 2 mM dithiothreitol and 5 mM iodoacetamide for 30 min at 37°C. Samples are subsequently dialysed. Latent collagenase is activated with 1 mM APt followed by inactivation with soy bean trypsin inhibitor. Collagenase is measured[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References
Molecular Weight

612.78

Formula

C₃₁H₄₄N₆O₅S

CAS No.

51165-05-0

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Shipping

Room temperature in continental US; may vary elsewhere

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Product Name:
Substance P 7-11
Cat. No.:
HY-P1492
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Substance P 7-11

Cat. No.: HY-P1492