1. Signaling Pathways
  2. GPCR/G Protein
    Neuronal Signaling
  3. 5-HT Receptor
  4. 5-HT Receptor Isoform
  5. 5-HT Receptor Antagonist

5-HT Receptor Antagonist

5-HT Receptor Antagonists (81):

Cat. No. Product Name Effect Purity
  • HY-12560A
    PNU-282987
    Antagonist 99.70%
    PNU-282987 is a potent α7 nicotinic acetylcholine receptor (nAChR) agonist with an EC50 of 154 nM.
  • HY-B0965
    Thioridazine hydrochloride
    Antagonist 99.96%
    Thioridazine hydrochloride, an orally active antagonist of the dopamine receptor D2 family proteins, exhibits potent anti-psychotic and anti-anxiety activities.
  • HY-B0478
    Trazodone hydrochloride
    Antagonist 99.87%
    Trazodone (hydrochloride) (AF-1161) is an antidepressant belonging to the class of serotonin receptor antagonists and reuptake inhibitors for treatment of anxiety disorders.
  • HY-108324
    (Z)-Thiothixene
    Antagonist 99.76%
    (Z)-Thiothixene is an antagonist of serotonergic receptor extracted from patent US 20150141345 A1.
  • HY-B1693
    Levomepromazine
    Antagonist 99.98%
    Levomepromazine (Methotrimeprazine) is an orally available neuroleptic agent, which is commonly used to relieve nausea and vomiting in palliative care settings.
  • HY-14537
    Latrepirdine dihydrochloride
    Antagonist 99.71%
    Latrepirdine dihydrochloride is a neuroactive compound with antagonist activity at histaminergic, α-adrenergic, and serotonergic receptors.
  • HY-107613
    R 59-022
    Antagonist 99.82%
    R 59-022 (DKGI-I) is a diacylglycerol kinase inhibitor (IC50=2.8 μM).
  • HY-30152
    Xanthotoxol
    Antagonist 99.58%
    Xanthotoxol (8-Hydroxypsoralen) is a biologically active linear furocoumarin, shows strong pharmacological activities as anti-inflammatory, antioxidant, 5-HT antagonistic, and neuroprotective effects.
  • HY-B0740
    Cyclobenzaprine hydrochloride
    Antagonist 99.91%
    Cyclobenzaprine hydrochloride (MK130 hydrochloride) is a skeletal muscle relaxant and a central nervous system (CNS) depressant.
  • HY-16978
    TG6-10-1
    Antagonist 99.92%
    TG6-10-1 is an EP2 antagonist, shows low-nanomolar antagonist activity against only EP2, >300-fold selectivity over human EP3, EP4, and IP receptors, 100-fold selectivity over EP1 receptors.
  • HY-B1371
    Spiperone
    Antagonist
    Spiperone is a potent dopamine D2, serotonin 5-HT1A, and serotonin 5-HT2A antagonist.
  • HY-N2510
    Myristicin
    Antagonist 99.89%
    Myristicine  act as a serotonin receptor antagonist, a weak monamine oxidase (MAO) inhibitor.
  • HY-110033
    Ecopipam hydrobromide
    Antagonist ≥99.0%
    Ecopipam (SCH 39166) hydrobromide is a potent, selective and orally active antagonist of dopamine D1/D5 receptor, with Kis of 1.2 nM and 2.0 nM, respectively.
  • HY-103093
    Zotepine
    Antagonist 99.66%
    Zotepine, an antipsychotic agent, is a potent antagonist of 5-HT2A, 5-HT2C, Histamine H1, α1-adrenergic and Dopamine D2 receptors, with Kds of 2.6 nM, 3.2 nM, 3.3 nM, 7.3 nM and 8 nM, respectively.
  • HY-12537
    Peptide 401
    Antagonist
    Peptide 401, a potent mast cell degranulating factor from bee venom, suppresses the increased vascular permeability due to intradermal injection of various smooth muscle spasmogens (histamine, and 5-HT).
  • HY-141422A
    4,4-Diphenylbutylamine hydrochloride
    Antagonist 99.00%
    4,4-Diphenylbutylamine shows affinity for the 5-HT2A and H1 receptors with Kis of 2589 and 1670 nM, respectively.
  • HY-B0965A
    Thioridazine
    Antagonist
    Thioridazine, an antagonist of the dopamine receptor D2 family proteins, exhibits potent anti-psychotic and anti-anxiety activities.
  • HY-B1622
    Cyproheptadine
    Antagonist
    Cyproheptadine is a potent and orally active 5-HT2A receptor antagonist, with antidepressant and antiserotonergic effects.
  • HY-14690
    Ecopipam
    Antagonist
    Ecopipam (SCH 39166) is a potent, selective and orally active antagonist of dopamine D1/D5 receptor, with Kis of 1.2 nM and 2.0 nM, respectively.
  • HY-N7512
    Asimilobine
    Antagonist
    Asimilobine is an aporphine isoquinoline alkaloid isolated from plant species of Magnolia obobata Thun.