Cannabinoid Receptor
Cannabinoid Receptor
Cannabinoid receptors are currently classified into three groups: central (CB1), peripheral (CB2) and GPR55, all of which are G-protein-coupled. CB1 receptors are primarily located at central and peripheral nerve terminals. CB2 receptors are predominantly expressed in non-neuronal tissues, particularly immune cells, where they modulate cytokine release and cell migration. Recent reports have suggested that CB2 receptors may also be expressed in the CNS. GPR55 receptors are non-CB1/CB2 receptors that exhibit affinity for endogenous, plant and synthetic cannabinoids. Endogenous ligands for cannabinoid receptors have been discovered, including anandamide and 2-arachidonylglycerol.
Cannabinoid Receptor Isoform Specific Products
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Cannabinoid Receptor Inhibitors
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Cannabinoid Receptor Agonists
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Cannabinoid Receptor Antagonists
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Cannabinoid Receptor Activators
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Cannabinoid Receptor Modulators
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Cannabinoid Receptor Chemical
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Cannabinoid Receptor Inducer
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Cannabinoid Receptor Degrader
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Cannabinoid Receptor Controls
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Cannabinoid Receptor Ligands
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Cannabinoid Receptor Related Products (451)
Related Products (451)
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Antibodies (1)
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Cannabinoid Receptor Isoform Comparison
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ABD459
0 ImagesCat. No.: HY-118056CAS No.: 1047670-51-8ABD459 is a CB1 receptor antagonist with significant effects on regulating food intake and sleep-wake cycles. ABD459 completely displaces CB1 agonist CP99540 (Ki = 8.6 nM) and antagonizes CP55940-induced GTPγS binding (KB = 7.7 nM). ABD459 may specifically modulate endogenous cannabinoid release through cholinergic activity and plays a role in attention and arousal regulation. ABD459 is suitable for research in neurological disorders.
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Olorinab (Standard)
0 ImagesCat. No.: HY-111110RCAS No.: 1268881-20-4Synonyms: APD 371 (Standard)
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CB1 antagonist 5
0 ImagesCB1 antagonist 5 (Compound 25) is an antagonist for CB1 cannabinoid receptor, with a Ki of 243 nM and an EC50 of 195 nM.
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Otenabant (Standard)
0 ImagesCat. No.: HY-10871RCAS No.: 686344-29-6Synonyms: CP-945598 (Standard)
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(-)-11-Hydroxy-Δ8-tetrahydrocannabivarin
0 ImagesCat. No.: HY-170725CAS No.: 1421594-84-4Synonyms: (-)-11-Hydroxy-Δ8-THCV(-)-11-Hydroxy-Δ8-tetrahydrocannabivarin ((-)-11-Hydroxy-Δ8-THCV) is a synthetic cannabinoid.
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exo-Tetrahydrocannabivarin methyl ether
0 ImagesCat. No.: HY-170693CAS No.: 132213-92-4Synonyms: Δ9,11-Tetrahydrocannabivarin methyl ether; exo-THCV methyl ether; (–)-Δ7-THCV methyl etherexo-Tetrahydrocannabivarin methyl ether (Δ9,11-Tetrahydrocannabivarin methyl ether) is structurally similar to known phytocannabinoids.
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10(S)-Hydroxy-9(R)-hexahydrocannabinol
0 ImagesCat. No.: HY-170043CAS No.: 73648-83-610(S)-Hydroxy-9(R)-hexahydrocannabinol is structurally similar to known phytocannabinoids.
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Yangonin (Standard)
0 ImagesYangonin (Standard) is the analytical standard of Yangonin. This product is intended for research and analytical applications. Yangonin exhibits affinity for the human recombinant cannabinoid CB1 receptor with an IC50 and a Ki of 1.79 μM and 0.72 μM, respectively.
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Δ8-THC-ethyl
0 ImagesCat. No.: HY-170710CAS No.: 51768-58-2Synonyms: Ethyl-Δ8-TetrahydrocannabinolΔ8-THC-ethyl (Ethyl-Δ8-Tetrahydrocannabinol) is structurally similar to known phytocannabinoids.
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Cannabigerophorol
0 ImagesCat. No.: HY-170740CAS No.: 55824-15-2Synonyms: CBGPCannabigerophorol (CBGP) is structurally similar to known synthetic cannabinoids.
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Palmitoylisopropylamide
0 ImagesCat. No.: HY-103324CAS No.: 189939-61-5Synonyms: PIAPalmitoylisopropylamide is a Palmitoylethanolamide analogue inhibits [3H]-Anandamide metabolism with a pI50 of 4.89.
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8β-Hydroxy-exo-THC
0 ImagesCat. No.: HY-168361CAS No.: 52522-55-18β-Hydroxy-exo-THC is a cannabinoid ether analogue with a weaker affinity for receptor sites, with an IC50 of 1.2 μM.
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Cannabigerorcin
0 ImagesCat. No.: HY-121011CAS No.: 38106-51-3Cannabigerorcin is a phenolic compound found in cannabis plants, featuring a diphenol backbone and a terpene side chain. By reacting with radiolabeled methylmagnesium carbonate (MMC), its carboxyl group can be 14C-labeled. Radiolabeled Cannabigerorcin is widely used in research on cannabinoid biosynthesis pathways and metabolic processes.
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ADB-BINACA
0 ImagesCat. No.: HY-168418CAS No.: 2748155-93-1ADB-BINACA is categorized as a synthetic cannabinoid.
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Δ8-THCBA-A
0 ImagesCat. No.: HY-170699CAS No.: 2022178-63-6Synonyms: Δ8-Tetrahydrocannabibutolic acid AΔ8-THCBA-A (Δ8-Tetrahydrocannabibutolic acid A) is structurally similar to known phytocannabinoids.
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6α-Oxycodol N-oxide
0 ImagesCat. No.: HY-W715183CAS No.: 71539-53-26α-Oxycodol N-oxide is structurally categorized as an opioid. 6α-Oxycodol N-oxide is a metabolite of Oxycodone.
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Tocrifluor 1117
0 ImagesCat. No.: HY-103336CAS No.: 1186195-59-4Synonyms: T1117Tocrifluor 1117 is a selective GPR55 ligand and fluorescent probe. Tocrifluor 1117 shows extremely low affinity for mouse CB1 receptors (Ki >1000 nM) and only weakly displaces CB1 agonists. Tocrifluor 1117 specifically activates GPR55 to trigger intracellular calcium oscillations, and binds to vascular smooth muscle, endothelial and adventitial cells; all these binding effects are inhibited by pretreatment with unlabeled AM251 or O1602. Tocrifluor 1117 can clearly visualize the distribution of GPR55 in vascular tissues via confocal microscopy, while its uptake in cancer cells is completely dependent on GPR55 expression.
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(±)-Ibipinabant (Standard)
0 ImagesSynonyms: (±)-SLV319 (Standard); (±)-BMS-646256 (Standard)(±)-Ibipinabant (Standard) is the analytical standard of (±)-Ibipinabant. This product is intended for research and analytical applications. (±)-Ibipinabant ((±)-SLV319) is the racemate of SLV319. (±)-Ibipinabant ((±)-SLV319) is a potent and selective cannabinoid-1 (CB-1) receptor antagonist with an IC50 of 22 nM.
