Cannabinoid Receptor
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Cannabinoid Receptor Ligands
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Cannabinoid Receptor Related Products (294)
Related Products (294)
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GAT100
0 ImagesCat. No.: HY-120093CAS No.: 1663564-42-8GAT100 is a negative allosteric modulator and covalent allosteric probe for cannabinoid receptor type 1 (CB1R). GAT100 acts as a positive allosteric modulator for orthosteric agonist CP55,940 binding to regulate the CB1R signaling pathway. GAT100 reduces the potency and efficacy of orthosteric CB1R agonists in terms of β-arrestin 1 recruitment, phosphorylation of PLCβ3 and ERK1/2, cAMP accumulation, and CB1R internalization. GAT100 is applicable to the research of psychobehavioral and somatic diseases.
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LBP1
0 ImagesCat. No.: HY-106010CAS No.: 1050478-18-6
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TC-C 14G
0 ImagesCat. No.: HY-103330CAS No.: 656804-72-7TC-C 14G (Compd 14g) is a Cannabinoid-1 Receptor (CB1R) inverse agonist, with a Ki of 4 nM and EC50 of 11 nM for HCB1R, respectively.
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BB-22
0 ImagesCat. No.: HY-12244CAS No.: 1400742-42-8BB-22 is a cannabinoid wih dopamine (DA) stimulant properties. BB-22 shows affinity to CB1 receptors with a Ki value of 0.11 nM and an EC50 value of 2.9 nM.
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CB1/2 agonist 4
0 ImagesCat. No.: HY-150030CAS No.: 2772949-38-7CB1/2 agonist 4 is a full CB1 agonist and CB2 partial agonist with EC50 values of 15.09 nM and 1.16 nM, respectively. CB1/2 agonist 4 also has hCB1 and hCB2 receptor affinities with Ki values of 1.1 nM and 4.2 nM, respectively. CB1/2 agonist 4 has a significant antinociceptive activity, and also can activate cannabinoid and TRPV1 receptor with values of IC50 and EC50 is 0.8 μM and 0.12 μM, respectively.
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O-2545 hydrochloride
0 ImagesCat. No.: HY-110048CAS No.: 874745-43-4O-2545 hydrochloride is a highly potent, water-soluble CB1/CB2 receptor agonist (with Ki values of 1.5 and 0.32 nM for CB1 and CB2 respectively), can be used for epilepsy, pain, multiple sclerosis research.
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UCM710
0 ImagesCat. No.: HY-120300CAS No.: 213738-77-3UCM710 is an endocannabinoid (eCB) hydrolysis inhibitor that increases the levels of N-arachidonoyl ethanolamine and 2-arachidonoylglycerol in neurons. UCM710 inhibits fatty acid amide hydrolase and α/β-hydrolase domain 6, but not monoacylglycerol lipase.
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2-Palmitoylglycerol (Standard)
0 ImagesCat. No.: HY-W013788RCAS No.: 23470-00-0Synonyms: 2-Palm-Gl (Standard)2-Palmitoylglycerol (Standard) is the analytical standard of 2-Palmitoylglycerol. This product is intended for research and analytical applications. 2-Palmitoylglycerol (2-Palm-Gl), an congener of 2-arachidonoylglycerol (2-AG), is a modest cannabinoid receptor CB1 agonist. 2-Palmitoylglycerol also may be an endogenous ligand for GPR119.
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Pregnenolone-d6
0 ImagesCat. No.: HY-B0151S3Synonyms: 3β-Hydroxy-5-pregnen-20-one-d6Pregnenolone-d6 (3β-Hydroxy-5-pregnen-20-one-d6) is the deuterium labeled Pregnenolone (HY-B0151) . Pregnenolone (3β-Hydroxy-5-pregnen-20-one) is a powerful neurosteroid, the main precursor of various steroid hormones including steroid ketones. Pregnenolone acts as a signaling-specific inhibitor of cannabinoid CB1 receptor, inhibits the effects of tetrahydrocannabinol (THC) that are mediated by the CB1 receptors. Pregnenolone can protect the brain from cannabis intoxication. Pregnenolone is also a TRPM3 channel activator, and also can weakly activate TRPM1 channels.
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GAT564
0 ImagesCat. No.: HY-144705CAS No.: 2851895-01-5GAT564 (Compound 15d) is a potent allosteric modulator of cannabinoid 1 receptor (CB1R) with EC50s of 87 and 320 nM respectively for cAMP and β-arrestin2. GAT564 markedly promotes orthosteric ligand binding to hCB1R. GAT564 is efficacious as a topical agent that significantly reduces intraocular pressure (IOP) in the ocular normotensive murine model of glaucoma.
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O-2093
0 ImagesCat. No.: HY-103340CAS No.: 439080-01-0O-2093 is a selective endocannabinoid anandamide (AEA) reuptake inhibitor with IC50 of 17.3 μM.
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N-(3-Hydroxyphenyl)-arachidonoyl amide
0 ImagesCat. No.: HY-W337358CAS No.: 183718-75-4N-(3-Hydroxyphenyl)-arachidonoyl amide (Compound 23) is an anandamide transport inhibitor with an IC50 of 21.3 μM.
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Levonantradol hydrochloride
0 ImagesCat. No.: HY-122109ACAS No.: 70222-86-5Synonyms: l-Nantradol hydrochloride; CP 50556-1 hydrochlorideLevonantradol (l-Nantradol) hydrochloride is an analog of delta (9)-tetrahydrocannabinol. Levonantradol acting as a potent anti-analgesic agent.
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γ-Linolenoyl monoethanolamide
0 ImagesCat. No.: HY-162298CAS No.: 150314-37-7γ-Linolenoyl monoethanolamide, a kind of fatty N-acyl ethanolamine, is an endocannabinoid.
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JHU-75528
0 ImagesCat. No.: HY-105238CAS No.: 947696-17-5JHU-75528 is a novel ligand of the cannabinoid receptor (CB1). JHU-75528 can be used in the research of imaging CB1 receptor.
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UCM707
0 ImagesCat. No.: HY-103341CAS No.: 390824-20-1UCM707, a potent and selective inhibitor of endocannabinoid uptake, potentiates hypokinetic and antinociceptive effects of Anandamide.
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O-Arachidonoyl glycidol
0 ImagesCat. No.: HY-131995CAS No.: 439146-24-4O-Arachidonoyl glycidol (compound 1) is a 2-arachidonoylglycerol (2-AG) analog. O-Arachidonoyl glycidol inhibits cytosolic 2-oleoylglycerol (2-OG) hydrolysis with an IC50 value of 4.5 µM. O-Arachidonoyl glycidol blocks 2-OG hydrolysis in membrane fractions and anandamide hydrolysis with IC50s of 19, 12 µM, respectively.
