Drug Derivative
Drug derivative
Drug derivatives are derived from parent compounds. They replace or add atoms and groups through chemical reactions to optimize the various properties of the parent compound and reduce side effects. The application of drug derivatives provides a diverse compound library for drug research and development and accelerates the discovery of new drugs. For example, urea derivatives Glibenclamide can prolong the blood sugar-lowering effect of anti-diabetic drugs.
References:
- [1]. Vardanyan RS, et al. Fentanyl-related compounds and derivatives: current status and future prospects for pharmaceutical applications. Future Med Chem. 2014 Mar;6(4):385-412.x
- [2]. Ghosh AK, et al. Urea Derivatives in Modern Drug Discovery and Medicinal Chemistry. J Med Chem. 2020 Mar 26;63(6):2751-2788.x
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Drug Derivative Related Products (4062)
Related Products (4062)
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Phrymarolin V
0 ImagesCat. No.: HY-N13770CAS No.: 1449376-84-4Phrymarolin V is a natural lignan.
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Riddelliine N-oxide
0 ImagesCat. No.: HY-N16468CAS No.: 75056-11-0Riddelliine N-oxide is a hepatotoxic agent. Riddelliine N-oxide is promising for research of liver-related diseases.
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9β-Hydroxyhexahydrocannabinol
0 ImagesCat. No.: HY-172748CAS No.: 80657-58-59β-Hydroxyhexahydrocannabinol is a synthetic cannabinoid derivative. 9β-Hydroxyhexahydrocannabinol exhibits cytotoxicity against various tumor cell lines, such as HCT-116, MCF-7, K562, MIAPaCa-2, PANC-1, A549, PC-3 and SW-620, with IC50 values ranging from 15.23 to 33.74 μM. 9β-Hydroxyhexahydrocannabinol can be used in the study of cancer.
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4-Dehydrowithaferin A
0 Images4-Dehydrowithaferin A is the analogue of withaferin A. Withaferin A is a withanolide isolated from Withania somnifera. 4-Dehydrowithaferin A has the potential for the research of multiple myeloma.
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Vaticanol A
0 ImagesCat. No.: HY-N16755CAS No.: 287101-82-0Vaticanol A is a natural phenolic compound.
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Cannabigerobutolic acid methyl ester
0 ImagesCat. No.: HY-172819Cannabigerobutolic acid methyl ester is a drug derivative. Cannabigerobutolic acid methyl ester can be used in research on neurological diseases.
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Karacolidine
0 ImagesCat. No.: HY-N17886CAS No.: 41655-13-4Karacolidine (compound 9) is an aconitine-type alkaloid. Karacolidine can be found in the lateral root of Aconitum carmichaeli Debx. (Radix Aconiti Lateralis).
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(S)-3-Hydroxy-1,5-diphenylpentan-1-one
0 ImagesCat. No.: HY-N17032CAS No.: 163086-00-8(S)-3-Hydroxy-1,5-diphenylpentan-1-one is a natural phenolic compound.
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14α/β-Vindeburnol
0 ImagesCat. No.: HY-105058ASynonyms: 14α/β-RU 2472214α/β-Vindeburnol (14α/β-RU 24722) a synthetic molecule derived from the eburnamine-vincamine alkaloid group, has many neuropsychopharmacological and antidepressant-like effects.
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Cannabiphorol
0 ImagesCat. No.: HY-168357CAS No.: 55824-14-1Cannabiphorol (compound 4d) is a rare cannabinoid closely related to cannabinol. Cannabiphorol has the potential for the research of synergistic effects when combined with other cannabinoids.
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Jatropholone B
0 ImagesCat. No.: HY-107219CAS No.: 71386-38-4Jatropholone B is a jatrophone derivative that can be isolated fromJatropha isabelliand has certain gastric protective effects.
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PAR4 antagonist 9-phosphoric acid
0 ImagesCat. No.: HY-183982CAS No.: 2173066-81-2PAR4 antagonist 9-phosphoric acid is a phosphate prodrug of the PAR4 antagonist 9 (HY-183983). PAR4 antagonist 9-phosphoric acid is applicable to research related to arterial thrombosis.
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1,2:5,6-Di-O-isopropylidene-L-chiro-inositol
0 ImagesCat. No.: HY-W726084CAS No.: 65556-81-21,2:5,6-Di-O-isopropylidene-L-chiro-inositol is a derivative of inositol.
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Adenostemmoic acid C
0 ImagesCat. No.: HY-N13574CAS No.: 130217-18-4Adenostemmoic acid C is a natural diterpene.
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RA-octil
0 ImagesCat. No.: HY-106857ACAS No.: 123060-44-6Synonyms: HOE 065RA-octil is a derivative related to angiotensin-converting enzyme inhibitors. RA-octil exhibits a memory promoting effect. RA-octil can be used for research on neurological conditions.
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Dichotomoside A
0 ImagesCat. No.: HY-N19797CAS No.: 845673-17-8Dichotomoside A is a neolignan glycoside. Dichotomoside A can be isolated from the roots of Stellaria dichotoma L. var. lanceolata.
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BAM-2101
0 ImagesCat. No.: HY-171798CAS No.: 115178-28-4BAM-2101 is an ergoline derivative with antihypertensive activity. BAM-2101 is orally active and lowers blood pressure in spontaneously hypertensive rats.
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Anticancer agent 347
0 ImagesAnticancer agent 347 is a heterobifunctional anticancer inhibitor with inhibitory activity against ERα-overexpressing cells and breast cancer cells. Anticancer agent 347 can be used for the research of breast cancer.
