Anticancer agent 347
Based on 1 Customer Validation
Anticancer agent 347 is a heterobifunctional anticancer inhibitor with inhibitory activity against ERα-overexpressing cells and breast cancer cells. Anticancer agent 347 can be used for the research of breast cancer.
For research use only. We do not sell to patients.
- Purity : 98.29%
- CAS No.: 3099595-91-9
- Formula: C46H53F3N10O3S
- Molecular Weight:883.04
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Storage:
-20°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
IC50 & Target
[1]|
ERα |
In Vitro
Anticancer agent 347 (I-33) exhibits potent antiproliferative activity against MCF7 breast cancer cells (GI50 < 0.05 μM)[1].
Anticancer agent 347 exerts potent and selective antiproliferative effects on Doxorubicin (HY-15142A)-induced estrogen receptor α-overexpressing T-Rex 293 cells (GI50 < 0.05 μM), while shows extremely weak inhibitory activity against T-Rex 293 cells without high estrogen receptor α expression (GI50 > 2.5 μM)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
Chemical Information
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CAS No. 3099595-91-9
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Appearance Solid
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Molecular Weight 883.04
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Formula C46H53F3N10O3S
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Color White to off-white
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SMILES
FC(F)(F)CN1[C@H](C2=CC=C(C=N2)NC3CN(C3)CCCOCCOCCOC4=CC=C(C5=N[C@@H](C)C6=NN=C(C)N6C7=C5C(C)=C(C)S7)C=C4)C8=C(C[C@H]1C)C9=CNN=C9C=C8
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
Solvent & Solubility
In Vitro:
DMSO : 100 mg/mL (113.25 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Protocols
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Breast Cancer Modeling
Breast cancer is a heterogeneous cancer, and it has been distinguished into four subtypes: luminal A, luminal B, HER2-positive and basal-like. Molecular mutations, epigenetic alterations, hormone exposure and immune microenvironment are related to the progression of breast cancer.
Purity & Documentation
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Data Sheet (272 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.1325 mL | 5.6623 mL | 11.3245 mL | 28.3113 mL |
| 5 mM | 0.2265 mL | 1.1325 mL | 2.2649 mL | 5.6623 mL | |
| 10 mM | 0.1132 mL | 0.5662 mL | 1.1325 mL | 2.8311 mL | |
| 15 mM | 0.0755 mL | 0.3775 mL | 0.7550 mL | 1.8874 mL | |
| 20 mM | 0.0566 mL | 0.2831 mL | 0.5662 mL | 1.4156 mL | |
| 25 mM | 0.0453 mL | 0.2265 mL | 0.4530 mL | 1.1325 mL | |
| 30 mM | 0.0377 mL | 0.1887 mL | 0.3775 mL | 0.9437 mL | |
| 40 mM | 0.0283 mL | 0.1416 mL | 0.2831 mL | 0.7078 mL | |
| 50 mM | 0.0226 mL | 0.1132 mL | 0.2265 mL | 0.5662 mL | |
| 60 mM | 0.0189 mL | 0.0944 mL | 0.1887 mL | 0.4719 mL | |
| 80 mM | 0.0142 mL | 0.0708 mL | 0.1416 mL | 0.3539 mL | |
| 100 mM | 0.0113 mL | 0.0566 mL | 0.1132 mL | 0.2831 mL |
Anticancer agent 347 Related Classifications
HY-184948 Related Classifications
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