Drug Derivative
Drug derivative
Drug derivatives are derived from parent compounds. They replace or add atoms and groups through chemical reactions to optimize the various properties of the parent compound and reduce side effects. The application of drug derivatives provides a diverse compound library for drug research and development and accelerates the discovery of new drugs. For example, urea derivatives Glibenclamide can prolong the blood sugar-lowering effect of anti-diabetic drugs.
References:
- [1]. Vardanyan RS, et al. Fentanyl-related compounds and derivatives: current status and future prospects for pharmaceutical applications. Future Med Chem. 2014 Mar;6(4):385-412.x
- [2]. Ghosh AK, et al. Urea Derivatives in Modern Drug Discovery and Medicinal Chemistry. J Med Chem. 2020 Mar 26;63(6):2751-2788.x
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Drug Derivative Related Products (4062)
Related Products (4062)
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5"-Methoxyhexahydrocurcumin
0 ImagesCat. No.: HY-N2680CAS No.: 138870-96-95"-Methoxyhexahydrocurcumin is a natural phenolic compound.
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WAY-660222
0 ImagesWAY-660222 is an active molecule.
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CAI0019
0 ImagesCAI0019 is an orally active α-carbonic anhydrase inhibitor based on the Acetazolamide (HY-B0782) framework. CAI0019 exhibits narrow-spectrum antibiofilm activity, with its MIC50 being 0.094 μM and MIC90 being 0.39 μM. CAI0019 selectively inhibits Enterococcus in a septic peritonitis mouse model, without affecting most intestinal commensal bacteria.
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Chaxine C
0 ImagesCat. No.: HY-N17405CAS No.: 1201264-24-5Chaxine C is a natural product that can be found in tea.
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Olcorolimus
0 ImagesCat. No.: HY-106979CAS No.: 186752-78-3Synonyms: SAR-943Olcorolimus (SAR-943) is a Rapamycin (HY-10219) derivative. Olcorolimus can reduce IL-4, IL-5, eosinophil, neutrophil, lymphocyte, cellular fibronectin; lung epithelial cell proliferation and mucus hypersecretory phenotype in Ovalbumin (HY-W250978)-sensitized BALB/c mice. Olcorolimus can be used for the researches of inflammation and immunology, such as asthma.
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14-Acetoxy parthenolide
0 ImagesCat. No.: HY-177714CAS No.: 2064236-08-214-Acetoxy parthenolide (compound 6a) is a parthenolide (PTL) derivative. 14-Acetoxy parthenolide exhibits potent anti-acute myeloid leukemia (AML) activity against HL-60 and KG1a cells, with IC50 values of 2.8 µM and 6.3 µM, respectively. 14-Acetoxy parthenolide can be used for AML research.
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Cys-HW12
0 ImagesCat. No.: HY-P11781ACAS No.: 1848230-00-1Cys-HW12 is a random peptide containing an N-terminal cysteine and derivative of HW12 (HY-P11781). Cys-HW12 can be coupled via the thiol group of Cys. Cys-HW12 can serve as a control for GE11 (HY-P10128)-conjugated mixed micelles targeting EGFR, and also functions as a cytotoxic agent, cellular uptake inhibitor, and tumor growth inhibitor. Cys-HW12 is applicable to pancreatic cancer-related research.
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AD-20
0 ImagesCat. No.: HY-119034CAS No.: 111542-07-5AD-20 is an o-methoxyphenylacetyl dehydroalanine derivative. AD-20 can not only reduce the acute and subchronic toxicity of Doxorubicin (HY-15142A), but also enhance its anti-tumor effect.
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Schisanwilsonin G
0 ImagesCat. No.: HY-N17298CAS No.: 1189056-63-0Schisanwilsonin G is a natural product that can be found in dendrobium.
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LY 97119
0 ImagesCat. No.: HY-114561CAS No.: 72456-59-8LY 97119 is an active compound.
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Anidoxime
0 ImagesCat. No.: HY-119844CAS No.: 34297-34-2Anidoxime is an Amidoxime derivative, and an orally active analgesic agent. Anidoxime can be used for the research of post-surgical pain.
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3-O-Coumaroylarjunolic acid
0 ImagesCat. No.: HY-N1856CAS No.: 171864-20-33-O-Coumaroylarjunolic acid is a natural triterpene.
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BO-0742
0 ImagesCat. No.: HY-119899CAS No.: 774234-08-1BO-0742, a derivative of AHMA and N-mustard, is a potent anti-cancer agent. BO-0742 significantly suppresses the growth of xenografts of human breast and ovarian cancers in mice.
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Crithmumdiol
0 ImagesCat. No.: HY-N17382CAS No.: 252024-20-7Crithmumdiol is a 17C-acetylene derivative that can be found in Crithmum maritimum L.
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Isodonhenrin D
0 ImagesCat. No.: HY-N16914CAS No.: 1392194-87-4Isodonhenrin D is a natural diterpene.
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Karelinine
0 ImagesCat. No.: HY-N18296Karelinine is a steroidal alkaloid found in the bulbs of Fritillaria ussuriensis Maxim and Fritillaria karelinii. Karelinine shows accelerated absorption and elimination rates, and increased area under the curve (AUC0-t) when administered as part of the nanodispersion preparation (FUN) in rat plasma following oral administration.
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Antitumor agent-50
0 ImagesCat. No.: HY-115995CAS No.: 2891985-53-6Antitumor agent-50 (compound 1a), a thiazolidinone, is a potent antitumor agent. Antitumor agent-50 has the potential for osteosarcoma (OS) research.
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Mangiferonic acid
0 ImagesCat. No.: HY-N19853CAS No.: 13878-90-5Mangiferonic acid is a triterpenoid found in the stems of Vatica diospyroides. Mangiferonic acid can be used for cancer research.
