Dynamin Inhibitor
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Amyloid-β-Drp1 PPI-IN-1
0 ImagesCat. No.: HY-134878CAS No.: 2227449-25-2Amyloid-β-Drp1 PPI-IN-1 is an Amyloid-β-Drp1 protein-protein interaction inhibitor. Amyloid-β-Drp1 PPI-IN-1 inhibits Aβ-Drp1 interaction and decreases Drp1 and Aβ levels. Amyloid-β-Drp1 PPI-IN-1 inhibits excessive mitochondrial fission and promotes mitochondrial fusion and biogenesis. Amyloid-β-Drp1 PPI-IN-1 also alleviates oxidative stress and improves mitochondrial function, and can be used for Alzheimer's disease research.
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Rhodady C10
0 ImagesCat. No.: HY-164290CAS No.: 1367579-04-1
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Clathrin-IN-5
0 ImagesCat. No.: HY-181933CAS No.: 339025-18-2Clathrin-IN-5 (Compound 9) is a Clathrin N-terminal domain-Amphiphysin protein-protein interaction inhibitor with an IC50 of 2.77 μM. Clathrin-IN-5 inhibits the protein-protein interaction between the clathrin N-terminal domain and amphiphysin. Clathrin-IN-5 inhibits clathrin-mediated endocytosis with an IC50 of 4.6 μM. Clathrin-IN-5 inhibits the GTPase activity of Dynamin I with an IC50 of 29.7 μM.
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L-Citrulline (GMP)
0 ImagesL-Citrulline GMP is an orally active, blood-brain barrier permeable neutral α-amino acid. L-Citrulline GMP inhibits the mitochondrial translocation of Drp1 and maintains mitochondrial homeostasis via a NO-dependent pathway, thereby reducing excessive ROS production. Consequently, L-Citrulline GMP protects sperm DNA integrity, stabilizes the blood-testis barrier and improves semen quality. L-Citrulline GMP can be used in research related to male infertility, mycobacterial infection (tuberculosis) and radiation combined injury.
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Dynasore (Standard)
0 ImagesDynasore (Standard) is the analytical standard of Dynasore. This product is intended for research and analytical applications. Dynasore is a cell-permeable dynamin inhibitor with an IC50 of 15 μM. Dynasore blocks cell migration.
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Schaftoside (Standard)
0 ImagesSchaftoside (Standard) is the analytical standard of Schaftoside. This product is intended for research and analytical applications. Schaftoside is a flavonoid found in a variety of Chinese herbal medicines, such as Eleusine indica. Schaftoside inhibits the expression of TLR4 and Myd88. Schaftoside also decreases Drp1 expression and phosphorylation, and reduces mitochondrial fission.
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Mdivi-1 (Standard)
0 ImagesCat. No.: HY-15886RCAS No.: 338967-87-6Synonyms: Mitochondrial division inhibitor 1 (Standard)Mdivi-1 (Standard) is the analytical standard of Mdivi-1. This product is intended for research and analytical applications. Mdivi-1 is a selective dynamin-related protein 1 (Drp1) inhibitor. Mdivi-1 is a mitochondrial division/mitophagy inhibitor.
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Dynole 34-2 (Standard)
0 ImagesCat. No.: HY-107545RCAS No.: 1128165-88-7Dynole 34-2 (Standard) is the analytical standard of Dynole 34-2 (HY-107545). This product is intended for research and analytical applications. Dynole 34-2 is a potent dynamin GTPase inhibitor (IC50s=6.9 and 14.2 µM for dynamin1 and dynamin2 GTPase activity, respectively) with antimitotic effect. Dynole 34-2 induces apoptosis, as revealed by cell blebbing, DNA fragmentation, and PARP cleavage. Dynole 34-2 also potently inhibits receptor mediated endocytosis (RME).
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Hydroxy-Dynasore (Standard)
0 ImagesCat. No.: HY-13863RCAS No.: 1256493-34-1Hydroxy-Dynasore (Standard) is the analytical standard of Hydroxy-Dynasore (HY-13863). This product is intended for research and analytical applications. Hydroxy Dynasore (Dyngo-4a), a structural mimetic analog of Dynasore (HY-15304), is an improved, less cytotoxic and versatile dynamin inhibitor with IC50 values of 0.38 μM and 2.3 μM for brain recombinant dynamin I and recombinant mouse dynamin II, respectively. Hydroxy Dynasore inhibits dynamin-dependent transferrin endocytosis with an IC50 of 5.7 μM.
