Factor Xa Activator
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Human α-Thrombin (Lyophilized)
0 ImagesArt. -Nr.: HY-114164HCAS. Nr.: 9002-04-4Synonyms: EC 3.4.21.5 (Lyophilized); Human Alpha Thrombin (Lyophilized)Human α-Thrombin (EC 3.4.21.5; Human Alpha Thrombin) (Lyophilized) is a terminal serine protease in the coagulation cascade, as well as a potent physiological platelet agonist and fibrin-generating enzyme in vivo. Human α-Thrombin catalyzes the conversion of fibrinogen to fibrin for blood clot formation, and activates platelet aggregation by cleaving the protease-activated receptors PAR1 (major) (Kd = 1 nM) and PAR4 (minor) on the platelet surface to expose tethered ligands. Human α-Thrombin also amplifies coagulation via positive feedback by activating coagulation factors V, VIII, XI (FV/FVIII/FXI), and switches to activate protein C to exert anticoagulant effects after binding to thrombomodulin.
This product is in a freeze-dried form.
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Darexaban glucuronide
0 ImagesArt. -Nr.: HY-19866CAS. Nr.: 432029-12-4Synonyms: YM-222714Darexaban glucuronide (YM-222714) is a active metabolite of darexaban (YM150). Darexaban glucuronide has an oral activity and antithrombotic effect.
