Filovirus Inhibitor

NS3-IN-1 (compound 302) is a potent helicase (NS3) inhibitor. NS3-IN-1 shows an potent inhibitor for yellow fever helicase.

pEBOV-IN-1 (Comp 2) is a pEBOV inhibitor, with an EC₅₀ value of 0.38 μM. pEBOV: pseudotyped Ebola virus.

EBOV entry-IN-2 (compound 16) is an EBOV entry inhibitor with an EC₅₀ of 4.42 μM. EBOV entry-IN-2 shows metabolic stability.

Antiviral agent 59 (compound 58) is an antiviral agent with selective and drug-like properties that inhibits a broad spectrum of filoviruses. Antiviral agent 59 exhibits low off-target activity and inhibition against replication-competent Ebola virus (EBOV), Sudan virus (SUDV), and Marburg virus (MARV).

Aloperine (Standard) is the analytical standard of Aloperine. This product is intended for research and analytical applications. Aloperine is an alkaloid in sophora plants such as Sophora alopecuroides L, which has shown anti-cancer, anti-inflammatory and anti-virus properties. Aloperine is widely used to treat patients with allergic contact dermatitis eczema and other skin inflammation in China. Aloperine induces apoptosis and autophagy in HL-60 cells.

EBOV entry-IN-1 (compound Hu7) is an EBOV entry inhibitor with an IC₅₀ of 1.50 μM.

Cephaeline ((-)-Cephaeline), a desmethyl analog of Emetine, is a phenolic alkaloid in Indian Ipecac roots isolated from the Cephaelis ipecacuanha. Cephaeline exhibits potent inhibition of both Zika virus (ZIKV) and Ebola virus (EBOV) infections. Cephaeline is an inductor of histone H3 acetylation and an inhibitor of mucoepidermoid carcinoma cancer stem cells (MEC), which promotes ferroptosis by inhibiting NRF2 to exert anti-lung cancer efficacy.

EBOV-IN-11 is a protein phosphatase 1 (PP1) inhibitor, with K_d values of 1.88 nM and 8.01 nM against wild-type and quadruple-mutant PP1, respectively. EBOV-IN-11 potently inhibits the replication and transcription of EBOV-eGFP virus. EBOV-IN-11 can be used in studies related to Ebola virus infection.

SMA-245 is an inhibitor of Filovirus glycoproteins, acting on Ebola virus (EBOV) and Marburg virus (MARV). SMA-245 blocks the endosomal membrane fusion step of filoviruses by binding to the EBOV GP1/GP2 fusion loop. SMA-245 inhibits MARV viral entry. SMA-245 can be used in research related to filovirus infections.

Antiviral agent 66 (Compound 60) is the inhibitor for Filovirus, that inhibits pseudotyped virus of Ebola, Marburg, Zaire, Sudan, Bundibugyo, Reston and Tai Forest with EC₅₀s of 0.16, 2.24, 0.16, 0.89, 0.21, 0.21 and 0.11 μM, respectively.

Antiviral agent 12 is a antiviral compound. Antiviral agent 12 inhibits Ebola virus entry into host cells by binding to surface glycoprotein, EC₅₀ is 3.9 μM. Antiviral agent 12 can be used in the study of Ebola virus.

Chlorphenoxamine (Standard) is the analytical standard of Chlorphenoxamine (HY-B1607). This product is intended for research and analytical applications. Chlorphenoxamine, an antihistamine and anticholinergic agent is a GPCR antagonist. Chlorphenoxamine inhibits multiple lethal viral diseases, such as SARS-CoV, MERS-CoV, EBOV and malaria. Chlorphenoxamine shows anti-filovirus activity against both EBOV and Marburg virus (MARV) with IC₅₀s of 1.1 μM and 6.2 μM, respectively. Chlorphenoxamine is used for allergic conditions, urticaria, viral diseases and Parkinson’s disease.

EBOV-GP-IN-1 (Compound 28) is a potent Ebola entry inhibitor with an IC₅₀ of 0.05 μM against Ebola virus envelope glycoprotein (EBOV-GP).