Chlorphenoxamine
Based on 1 publication(s) in Google Scholar
Chlorphenoxamine, an antihistamine and anticholinergic agent is a GPCR antagonist. Chlorphenoxamine inhibits multiple lethal viral diseases, such as SARS-CoV, MERS-CoV, EBOV and malaria. Chlorphenoxamine shows anti-filovirus activity against both EBOV and Marburg virus (MARV) with IC50s of 1.1 μM and 6.2 μM, respectively. Chlorphenoxamine is used for allergic conditions, urticaria, viral diseases and Parkinson’s disease.
For research use only. We do not sell to patients.
- Purity: 99.20%
- CAS No.: 77-38-3
- Formula: C18H22ClNO
- Molecular Weight:303.83
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Storage:Pure form -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Publications Citing Use of MedChemExpress (MCE) Chlorphenoxamine
MoreAll Histamine Receptor Isoforms
MoreAll Parasite Isoforms
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Biological Activity
Chlorphenoxamine shows a CC50 of 55.3 μM for A549 cells[5].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 77-38-3
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Appearance Liquid (Density: 1.093±0.06 g/cm3)
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Molecular Weight 303.83
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Formula C18H22ClNO
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Color Light yellow to brown
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SMILES
CN(CCOC(C1=CC=CC=C1)(C2=CC=C(C=C2)Cl)C)C
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Pure form -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (1)
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Journal Impact Factor
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Most Recent
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Antiviral Res
Repurposing potential of 1st generation H1-specific antihistamines as anti-filovirus therapeutics. [Abstract]2018 Sep:157:47-56. PMID: 29981374
Solvent & Solubility
DMSO : ≥ 48 mg/mL (157.98 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.08 mg/mL (6.85 mM); Clear solution
This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.08 mg/mL (6.85 mM); Clear solution
This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
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Data Sheet (275 KB)
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SDS (393 KB)
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Handling Instructions (2659 KB)
References
[1]. Ashraf A, et al. Novel RP-HPLC-DAD approach for simultaneous determination of chlorphenoxamine hydrochloride and caffeine with their related substances. BMC Chem. 2024;18(1):133. Published 2024 Jul 19. [Content Brief]
[2]. Ashraf A, et al. Smart green spectrophotometric estimation and content uniformity testing of chlorphenoxamine HCl and caffeine in bulk forms and combined pharmaceutical formulation. Sci Rep. 2025;15(1):9482. Published 2025 Mar 19. [Content Brief]
[3]. BAZEX A, et al. Trial treatment of urticaria with chlorphenoxamine. Clinique (Paris). 1963 Jul-Aug;58:447-50. [Content Brief]
[4]. ULDALL PR, et al. Chlorphenoxamine hydrochloride in parkinsonism. A controlled trial. Br Med J. 1961 Jun 10;1(5240):1649-52. [Content Brief]
[5]. Schafer A, et al. Repurposing potential of 1st generation H1-specific antihistamines as anti-filovirus therapeutics. Antiviral Res. 2018 Sep;157:47-56. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.2913 mL | 16.4566 mL | 32.9131 mL | 82.2829 mL |
| 5 mM | 0.6583 mL | 3.2913 mL | 6.5826 mL | 16.4566 mL | |
| 10 mM | 0.3291 mL | 1.6457 mL | 3.2913 mL | 8.2283 mL | |
| 15 mM | 0.2194 mL | 1.0971 mL | 2.1942 mL | 5.4855 mL | |
| 20 mM | 0.1646 mL | 0.8228 mL | 1.6457 mL | 4.1141 mL | |
| 25 mM | 0.1317 mL | 0.6583 mL | 1.3165 mL | 3.2913 mL | |
| 30 mM | 0.1097 mL | 0.5486 mL | 1.0971 mL | 2.7428 mL | |
| 40 mM | 0.0823 mL | 0.4114 mL | 0.8228 mL | 2.0571 mL | |
| 50 mM | 0.0658 mL | 0.3291 mL | 0.6583 mL | 1.6457 mL | |
| 60 mM | 0.0549 mL | 0.2743 mL | 0.5486 mL | 1.3714 mL | |
| 80 mM | 0.0411 mL | 0.2057 mL | 0.4114 mL | 1.0285 mL | |
| 100 mM | 0.0329 mL | 0.1646 mL | 0.3291 mL | 0.8228 mL |
Chlorphenoxamine Related Classifications
HY-B1607 Related Classifications
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