Fungal
An antifungal agent is a drug that selectively eliminates fungal pathogens from a host with minimal toxicity to the host.
Classes: 1. Polyene Antifungal Drugs: Amphotericin, nystatin, and pimaricin interact with sterols in the cell membrane (ergosterol in fungi, cholesterol in humans) to form channels through which small molecules leak from the inside of the fungal cell to the outside. 2. Azole Antifungal Drugs: Fluconazole, itraconazole, and ketoconazole inhibit cytochrome P450-dependent enzymes (particularly C14-demethylase) involved in the biosynthesis of ergosterol, which is required for fungal cell membrane structure and function. 3. Allylamine and Morpholine Antifungal Drugs: lylamines (naftifine, terbinafine) inhibit ergosterol biosynthesis at the level of squalene epoxidase. The morpholine drug, amorolfine, inhibits the same pathway at a later step. 4. Antimetabolite Antifungal Drugs: 5-Fluorocytosine acts as an inhibitor of both DNA and RNA synthesis via the intracytoplasmic conversion of 5-fluorocytosine to 5-fluorouracil.
All Product Categories
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Fungal Related Products (2751)
Related Products (2751)
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Antibodies (1)
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Related Compound Screening Libraries (1)
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Coprogen
0 ImagesCat. No.: HY-W698224CAS No.: 31418-71-0Coprogen is an iron growth factor with growth-promoting activity. Coprogen promotes the growth of Pilobolus kleinii and coprophilous fungal, and its activity depends on its own organic iron structure.
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Griseofulvin-13C,d3
0 ImagesCat. No.: HY-17583S1CAS No.: 1329612-29-4Griseofulvin-13C,d3 is the 13C- and deuterium labeled Griseofulvin.
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CYP51/PD-L1-IN-3
0 ImagesCat. No.: HY-156151CAS No.: 3032386-59-4CYP51/PD-L1-IN-3 (compound L21) is a quinazoline compound with antifungal activity. CYP51/PD-L1-IN-3 is a dual inhibitor of CYP51 (IC50: 0.205 μM) and PD-L1 (IC50: 0.039 μM), which can induce early apoptosis of fungal cells in the cell cycle. CYP51/PD-L1-IN-3 also significantly reduced intracellular IL-2, NLRP3, and NF-κBp65 protein levels, induced mitochondrial damage and ROS accumulation, and ultimately led to fungal lysis and death.
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Ethaboxam-d5
0 ImagesCat. No.: HY-W705792Synonyms: Intego solo-d5Ethaboxam-d5 (Intego solo-d5) is the deuterium labeled Ethaboxam (HY-107492). Ethaboxam is a β-tubulin inhibitor that can be used as anti-oomycete fungicide.
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Nystatin A2
0 ImagesCat. No.: HY-152909CAS No.: 65086-32-0Nystatin A2 is an active component of antifungal agent, Nystatin (HY-17409). Nystatin is an orally active polyene antifungal antibiotic effective against yeast and mycoplasma.
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Naftifine-13C,d3
0 ImagesCat. No.: HY-B0518S3Naftifine-13C,d3 is the 13C- and deuterium labeled Naftifine. Naftifine hydrochloride is an antibiotic. Naftifine hydrochloride has antifungal activity against dermatophytes, aspergilli, Sporothrix schenckii, and yeasts of the genus Candida. Naftifine hydrochloride can be used for the research of superficial dermatomycoses inhibition.
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Eyebright extract
0 ImagesCat. No.: HY-N20367Synonyms: Euphrasia pectinata extract; Euphrasy extractEyebright extract (Euphrasia pectinata extract) is an extract of eyebright grass (Herba Euphrasiae) with multiple activities including anti-inflammatory, antioxidant, antibacterial, anticancer, antifungal, and antiviral properties.
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Phosphomannose isomerase
0 ImagesPhosphomannose isomerase is the first enzyme involved in the biosynthesis pathway of GDP-Man. Phosphomannose isomerase catalyzes the conversion between fructose-6-phosphate (Fru6P) and mannose-6-phosphate (Man6P). Phosphomannose isomerase is important for cell wall synthesis and protein glycosylation. Phosphomannose isomerase is a potent antifungal target to curb the threats posed by A. flavus.
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Calcium Gluconate solution
0 ImagesCat. No.: HY-FLY0569BCAS No.: 66905-23-5Calcium Gluconate solution is mainly composed of Calcium gluconate monohydrate (HY-Y0569B). Calcium gluconate is an orally effective calcium salt supplement. Calcium gluconate reduces elevated serum potassium, decreased serum calcium, and postoperative myalgia associated with succinylcholine administration. Calcium gluconate restores calcium homeostasis, skeletal integrity, bone mineralization and bone density, and maintains levels of parathyroid hormone, bone resorption markers and osteoclasts. Calcium gluconate reverses LPS (HY-D1056)-induced ERK phosphorylation, inflammatory cytokine release and acute lung injury, alleviates airway inflammatory damage and suppresses immune responses. Calcium gluconate can be used in research related to postoperative myalgia, osteoporosis/osteomalacia and acute lung injury.
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Zeorin
0 ImagesCat. No.: HY-N1049CAS No.: 22570-53-2Synonyms: α-ZeorinZeorin is a compound isolated from the lichen Parmotrema sancti-angelii.
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Tunicamycin X
0 ImagesCat. No.: HY-N18360CAS No.: 66081-38-7Synonyms: Tunicamycin 17:1Tunicamycin X (Tunicamycin 17:1) is a nucleoside Antibiotic. Tunicamycin X is isolated from Streptomyces xinghaiensis SCSIO S15077. Tunicamycin X acts as a growth inhibitor against bacteria and fungi. Tunicamycin X inhibits the growth of Bacillus thuringiensis strains. Tunicamycin X inhibits the growth of Candida albicans strains.
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SDH-IN-15
0 ImagesCat. No.: HY-158321SDH-IN-15 (Compound 5e) is an inhibitor of succinate dehydrogenase (SDH) (IC50=2.04 μM). SDH-IN-15 has significant antifungal activity. SDH-IN-15 blocks the mitochondrial respiratory chain of the fungus through inhibition of SDH, resulting in fungal death.
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BI-10
0 ImagesCat. No.: HY-145873CAS No.: 2759037-58-4BI-10 is an antifungal compound. BI-10 combined with Fluconazole can inhibit hyphal growth, result in ROS accumulation, and decrease mitochondrial membrane potential (MMP) as well as altering membrane permeability.
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Corydalmine
0 ImagesSynonyms: L-Corydalmine; TLZ-16Corydalmine (L-Corydalmine) inhibits spore germination of some plant pathogenic as well as saprophytic fungi. Corydalmine acts as an oral analgesic agent, exhibiting potent analgesic activity. Corydalmine alleviates Vincristine-induced neuropathic pain in mice by inhibiting an NF-κB-dependent CXCL1/CXCR2 signaling pathway.
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Koninginin D
0 ImagesCat. No.: HY-N19824CAS No.: 119903-56-9Koninginin D is a potent antifungal agent that can be isolated from fungi including Trichoderma applanatum. Koninginin D inhibits growth of various fungal species including Gaeumannomyces graminis var. tritici, Bipolaris sorokiniana and so on. Koninginin D can be used for the research of fungal infection.
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(Rac)-CPI-098
0 Images(Rac)-CPI-098 shows antibacterial activity. (Rac)-CPI-098 exhibits superior anti-fungal activity against Monascus ruber, better activity against Aspergillus fumigates, good activity against Aspergillus niger and Aspergillus parasites and moderate activity against Candida albicans.
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SDH-IN-3
0 ImagesCat. No.: HY-155004CAS No.: 2805297-11-2SDH-IN-3 is a succinate dehydrogenase (SDH) inhibitor with an IC50 of 7.2 μg/mL. SDH-IN-3 exhibits excellent antifungal activities against Nigrospora oryzae with an EC50 of 1.9 μg/mL. SDH-IN-3 can be used for anti-infection research.
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Ansatrienin A
0 ImagesCat. No.: HY-126559CAS No.: 82189-03-5Synonyms: Mycotrienin IAnsatrienin A is an antifungal antibiotic that can be isolated from Streptomyces collinus.
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Nidulol
0 ImagesCat. No.: HY-N16432CAS No.: 17811-38-0Nidulol is a compound that can be isolated from the fungus Aspergillus nidulans metabolites. Nidulol shows no phytotoxic activity against Zea mays and Medicago polymorpha L. at a concentration of 5 mM.
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Penicolinate B
0 ImagesCat. No.: HY-N12230CAS No.: 1418291-70-9Penicolinate B is a picolinic acid derivative that can be isolated from Penicillium sp. Penicolinate B exhibits antimalarial activity (IC50: 1.40 μg/mL), antitubercular activity (MIC: 25.0 μg/mL), activity against Bacillus cereus (IC50: 25.0 μg/mL), and activity against Candida albicans (IC50: 1.45 μg/mL). Penicolinate B also has certain cytotoxicity against cancer cells such as MCF-7, KB, and NCI-H187. Penicolinate B can be used in research on malaria, tuberculosis, bacterial/fungal infections and tumors.
