2. Signaling Pathways
  3. GPCR/G Protein
    Neuronal Signaling
  4. GPR119
  5. GPR119 Activator

GPR119 Activator

GPR119 Activators (2):

Cat. No. Product Name Effect Purity
  • HY-125646
    YH18968
    		Activator
    YH18968 is an orally active GPR119 agonist with an EC50 of 2.8 nM for inducing cAMP accumulation. YH18968 activates GPR119, elevates intracellular cyclic adenosine monophosphate levels, stimulates glucagon-like peptide-1 secretion from intestinal L cells, and triggers glucose-dependent insulin secretion from pancreatic β cells. YH18968 improves glucose tolerance in normal mice and diet-induced obese mice. YH18968 can be used for the research of type 2 diabetes.
  • HY-18354
    GSK1104252A
    		Activator
    GSK1104252A is a potent and selective GPR119 agonist. GSK1104252A can be used for type 2 diabetes research.