Glycosidase
Glycosidase
Glycosidase are a class of enzymes which catalyze the hydrolysis of glycosidic bonds. In living organisms, Glycosidase are involved in carbohydrate metabolism. They can degrade polysaccharides such as starch and glycogen into monosaccharides, providing energy for cells. Glycosidase also participate in the synthesis and modification of biological macromolecules such as glycoproteins and glycolipids, playing a crucial role in cell recognition and signal transduction. Additionally, in plants and microorganisms, Glycosidase are involved in the metabolism of cell wall polysaccharide components, affecting cell growth, differentiation, and morphogenesis. Gene mutations of Glycosidase can trigger genetic diseases, leading to abnormal metabolism in the body and damage to organ functions. Changes in their activity are associated with various diseases such as diabetes, infectious diseases, and tumors, and can influence the occurrence and development of diseases[1][2].
References:
- [1]. Wang X, et al. Metabolites extracted from microorganisms as potential inhibitors of glycosidases (α-glucosidase and α-amylase): A review. Front Microbiol. 2022 Nov 17;13:1050869.
- [2]. Ohtsubo K, et al. Glycosylation in cellular mechanisms of health and disease. Cell. 2006 Sep 8;126(5):855-67. [Content Brief]
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Glycosidase Inhibitors
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Glycosidase Antagonist
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Glycosidase Activators
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Glycosidase Modulators
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Glycosidase Chemical
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Glycosidase Inducers
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Glycosidase Degrader
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Glycosidase Controls
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Glycosidase Substrates
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Glycosidase Ligands
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Glycosidase Related Products (682)
Related Products (682)
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Antibodies (3)
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α-Glucosidase-IN-45
0 ImagesCat. No.: HY-157311CAS No.: 3026192-46-8α-Glucosidase-IN-45 (compound 11E) is an inhibitor of α-glucosidase. α-Glucosidase-IN-45 is a novel indol-fused pyrano[2,3-D]pyrimidine compound.
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Migalastat-d5
0 ImagesCat. No.: HY-W728096Synonyms: GR181413A-d5 free baseMigalastat-d5 (GR181413A-d5 (free base)) is deuterium labeled Migalastat. Migalastat (GR181413A free base) is an orally active α-galactosidase A molecular chaperone, with an IC50 value of 0.04 μM for human α-Gal A. Migalastat binds to the active site of certain unstable mutant forms of α-galactosidase A, facilitating their transport to the lysosome. After dissociation in the acidic environment, Migalastat enables the mutant α-galactosidase A to exhibit biological activity.
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1'-O-Methyl neochebulinate
0 ImagesCat. No.: HY-N12500CAS No.: 1236310-34-11'-O-Methyl neochebulinate, hydrolyzable tannin, is an α-glucosidase inhibitor with IC50 value of 59.5 μM, isolated from the fruits of Terminalia chebula Retz.
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Oroxin A (Standard)
0 ImagesCat. No.: HY-N2025RCAS No.: 57396-78-8Oroxin A (Standard) is the analytical standard of Oroxin A. This product is intended for research and analytical applications. Oroxin A is the major component of an ethanol-water Oroxylum indicum (L.) Kurz (Bignoniaceae) seed extract (OISE). Oroxin A acts as a partial PPARγ agonist that can activate PPARγ transcriptional activation. Oroxin A activates PPARγ by docking into the PPARγ protein ligand-binding domain. Oroxin A also exhibits an inhibitory activity against α-glucosidase and an antioxidant capacity. Oroxin A exerts anti-breast cancer effects by inducing ER stress-mediated senescence.
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Rhodomyrtosone D
0 ImagesCat. No.: HY-N19904CAS No.: 1079988-19-4Rhodomyrtosone D is a natural α-glucosidase and BCL-2 inhibitor. Rhodomyrtosone D exhibits an IC50 of 110.45 μg/mL against α-glucosidase derived from Saccharomyces cerevisiae. Rhodomyrtosone D interferes with carbohydrate digestion, interacts with specific BCL-2 amino acid residues, and reduces postprandial blood glucose levels. Rhodomyrtosone D can be used in the research of diabetes and breast cancer.
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Acarbose-d4
0 ImagesCat. No.: HY-B0089SCAS No.: 1260619-60-0Synonyms: BAY g 5421-d4Acarbose-d4 (BAY g 5421-d4) is deuterium labeled Acarbose. Acarbose (BAY g 5421), antihyperglycemic agent, is an orally active alpha-glucosidase inhibitor (IC50=11 nM). Acarbose can potentiate the hypoglycemic effects of sulfonylureas or insulin.
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3-Hydroxyproline
0 ImagesCat. No.: HY-W354556CAS No.: 567-36-23-Hydroxyproline is a non-glycosyl microbial α-glucosidase inhibitor. 3-Hydroxyproline is used in the research of diabetes (type 2 diabetes/non-insulin-dependent diabetes mellitus).
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Ambroxol-d5
0 ImagesCat. No.: HY-W739944CAS No.: 1246818-80-3Synonyms: NA-872-d5Ambroxol-d5 (NA-872-d5) is deuterium labeled Ambroxol. Ambroxol (NA-872), an active metabolite of the proagent Bromhexine, has potent expectorant effects. Ambroxol is a glucocerebrosidase (GCase) chaperone and increases glucocerebrosidase activity. Ambroxol induces lung autophagy and has the potential for Parkinson disease and neuronopathic Gaucher disease research.
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N-5-Carboxypentyl-1-deoxynojirimycin
0 ImagesCat. No.: HY-121991CAS No.: 79206-51-2N-5-Carboxypentyl-1-deoxynojirimycin is an alpha-glucosidase inhibitor, and also can be used to prepare affinity matrices for binding to resins.
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Tyrosinase-IN-47
0 ImagesCat. No.: HY-180506Tyrosinase-IN-47 (compound 6a) is a potent competitive tyrosinase inhibitor with an IC50 of 1.43 µM and a Ki of 0.1142 μM. Tyrosinase-IN-47 also shows inhibition activity in α-Glucosidase (IC50 = 36.26 μM) and acetylcholinesterase (IC50 = 8.26 μM). Tyrosinase-IN-47 exhibits in vitro antioxidant activity, with good scavenging ability for DPPH (IC50 = 4.75 μM) and ABTS (IC50 = 0.04 μM). Tyrosinase-IN-47 displays anti-browning effect on freshly cut potatoes. Tyrosinase-IN-47 can be used for pharmaceutical research.
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Sativanone
0 ImagesCat. No.: HY-N15138CAS No.: 70561-31-8Sativanone is a compound that can be isolated from Dalbergia tonkinensis. Sativanone is a potent α-glucosidase inhibitor, with an EC50 of 0.357 mg/mL for rat α-glucosidase. Sativanone has antibacterial activity against Ralstonia solanacearum. Sativanone also has anti-senescent and antioxidant effects.
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ALR2/α-GLY-IN-1
0 ImagesCat. No.: HY-181519ALR2/α-GLY-IN-1 is a potent dual-target inhibitor that targets aldose reductase ALR2 and α-glucosidase (IC50 values are 0.72 μM and 0.82 μM, respectively; Ki values are 1.67 μM and 1.37 μM, respectively). ALR2/α-GLY-IN-1 also acts as a DNA binder, which stably interacts with calf thymus double-stranded DNA through non-covalent interactions such as groove-binding mode and water-bridged hydrogen bonds. ALR2/α-GLY-IN-1 can be used in studies related to diabetes and its complications.
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N-Nonyldeoxynojirimycin (Standard)
0 ImagesCat. No.: HY-107532RCAS No.: 81117-35-3Synonyms: NN-DNJ (Standard); Nonyl-DNJ (Standard)N-Nonyldeoxynojirimycin (Standard) is the analytical standard of N-Nonyldeoxynojirimycin (HY-107532). This product is intended for research and analytical applications. N-Nonyldeoxynojirimycin (NN-DNJ) is a deoxynojirimycin derivative with a hydrophobic long chain. N-Nonyldeoxynojirimycin is an orally active inhibitor of acid α-glucosidase (IC50: 0.42 μM) and α-1,6-glucosidase (IC50: 8.4 μM). N-Nonyldeoxynojirimycin has activities of inhibiting glycogen breaKdown, anti-virus and anti-tumor. N-Nonyldeoxynojirimycin also has insecticidal effects, with an LD50 of 5 mM for adults of Bemisia tabaci.
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Panosialin D
0 ImagesCat. No.: HY-N14904CAS No.: 162857-89-8Panosialin D can inhibit α,β-glucosidase and mannose glycosidase. Panosialin D does not inhibit the influenza virus, but it has weak anti-microbial effect.
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α-Amylase-IN-15
0 ImagesCat. No.: HY-184382α-Amylase-IN-15 is a dual inhibitor of α-amylase and α-glucosidase, with IC50 values of 6.7 μM and 18.55 μM, respectively, and a Ki value of 50.9 μM against α-amylase. α-Amylase-IN-15 binds to both free α-amylase and the enzyme-substrate complex. By inhibiting α-glucosidase, α-Amylase-IN-15 achieves dual inhibition of carbohydrate metabolic enzymes. α-Amylase-IN-15 can be used in the research of type 2 diabetes.
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Momilactone B
0 ImagesMomilactone B is an inhibitor of α-amylase and α-glucosidase, with an IC50 of 146.85 μg/mL against Aspergillus oryzae α-amylase and an IC50 of 612.03 μg/mL against Saccharomyces cerevisiae α-glucosidase. Momilactone B upregulates the expression of p21Waf1/Cip1, reduces the kinase activity of Cdk4 and Cdk6, induces cell cycle arrest and apoptosis in cancer cells, and triggers irreversible cell death via cell membrane damage. Momilactone B inhibits the growth of neighboring plant species and serves as a major contributing factor to the allelopathy of rice. Momilactone B can be used in studies related to rice allelopathy, type 2 diabetes, colon cancer and leukemia.
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N-Caffeoyl O-methyltyramine (Standard)
0 ImagesCat. No.: HY-N7203RCAS No.: 189307-47-9N-Caffeoyl O-methyltyramine (Standard) is the analytical standard of N-Caffeoyl O-methyltyramine. This product is intended for research and analytical applications. N-Caffeoyl O-methyltyramine is a class of alkaloid isolated from Cuscuta reflexa with strong inhibitory activity against α-glucosidase (IC50 of 103.58 μM).
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Voglibose-13C3
0 ImagesCat. No.: HY-W749516Voglibose-13C3 is the 13C-labeled Voglibose (HY-B0025). Voglibose is an orally active alpha-glucosidase inhibitor that prevents the development of colorectal precancerous lesions induced by obesity and diabetes. Voglibose reduces oxidative stress in an inflammatory environment and inhibits the insulin-like growth factor/insulin-like growth factor-1 receptor (IGF/IGF-1R) functional axis.
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Chrysin-7-O-glucuronide (Standard)
0 ImagesCat. No.: HY-N2376RCAS No.: 35775-49-6Chrysin-7-O-glucuronide (Standard) is the analytical standard of Chrysin-7-O-glucuronide (Hy-N2376). This product is intended for research and analytical applications. Chrysin-7-O-glucuronide is a flavonoid found in Scutellaria baicalensis. Chrysin-7-O-glucuronide inhibits α-glucosidase and α-amylase with IC50 values of 612.13 and 980.73 μg/mL. Chrysin-7-O-glucuronide suppresses NF-κB signaling activity. Chrysin-7-O-glucuronide scavenges free radicals, acts as a tight junction protector, and mitigates intestinal mucosal barrier injury. Chrysin-7-O-glucuronide can be used for the research of type 2 diabetes and severe acute pancreatitis-induced intestinal mucosal barrier injury.
