Nicothiazone
Nicothiazone is an α-glucosidase inhibitor with a yeast α-glucosidase IC50 of 120.20 μM. Nicothiazone inhibits α-glucosidase enzyme activity. Nicothiazone can be used for the research of type-II diabetes mellitus.
For research use only. We do not sell to patients.
- CAS No.: 555-90-8
- Formula: C7H8N4S
- Molecular Weight:180.23
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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α‑glucosidase 120.20 μM (IC50) |
Nicothiazone (compound 1) (10 min pre-incubation; 30 min reaction incubation) potently inhibits Baker's yeast α-glucosidase with an IC50 of 120.20 μM, showing greater potency than Acarbose (HY-B0089)[1].
Nicothiazone interacts with Saccharomyces cerevisiae α-glucosidase via hydrogen bonding with residues Asp349 and His111, supporting its inhibitory activity[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 555-90-8
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Molecular Weight 180.23
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Formula C7H8N4S
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SMILES
S=C(N)NN=CC=1C=NC=CC1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Nicothiazone Related Classifications
HY-119534 Related Classifications
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