2. Signaling Pathways
  3. NF-κB
  4. IKK
  5. IKK Control

IKK Control

IKK Isoform Comparison

IKK Controls (2):

Cat. No. Product Name Effect Purity
  • HY-69047
    6-Chloro-7-deazaguanine
    		Control 99.83%
    6-Chloro-7-deazaguanine is an inactive molecule of IKK (lacking the critical 5-cyano group). IKKβ and IKKα are core molecules in the canonical NF-κB pathway and non-canonical NF-κB pathway, respectively.
  • HY-183100
    UNC8461
    		Control
    UNC8461 is a PROTAC and is negative control CRBN-recruiting PROTAC analog of UNC8209 (HY-183098). UNC8461 features a methyl group substitution on its CRBN ligand to disrupt CRBN binding. UNC8461 fails to reduce TBK1, AAK1, GAK, and AURKA protein levels in renal cancer cells. UNC8461 does not suppress 3-D soft agar colony formation in renal cancer cells, and exerts modest, partial inhibition on colony formation in some renal cancer cells.