Indoleamine 2,3-Dioxygenase (IDO)
Indoleamine 2, 3-dioxygenase (IDO) is an inflammatory cytokine-inducible rate-limiting enzyme of the tryptophan (Trp) catabolism, which is involved in the inhibition of intracellular pathogen replication as well as in immunomodulation. To date, three types of tryptophan-metabolizing enzymes have been identified: IDO1, IDO2 and tryptophan 2,3-dioxygenase 2.
IDO is an intracellular enzyme that is constitutively expressed in several human and mouse cells. Being present in innate immune cells, such as Mos and dendritic cells (DCs), IDO catalyzes the initial rate-limiting step of tryptophan (Trp) catabolism, thus leading to the production of immunoregulatory catabolites (collectively known as kynurenines).
The IDO gene promoter contains multiple sequence elements that confer responsiveness to proinflammatory mediators, thereby demonstrating the strong correlation between inflammation and induced IDO expression.
Indoleamine 2,3-Dioxygenase (IDO) Isoform Specific Products
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Indoleamine 2,3-Dioxygenase (IDO) Inhibitors
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Indoleamine 2,3-Dioxygenase (IDO) Antagonist
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Indoleamine 2,3-Dioxygenase (IDO) Activators
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Indoleamine 2,3-Dioxygenase (IDO) Degraders
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Indoleamine 2,3-Dioxygenase (IDO) Ligand
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IDO Proteins
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Indoleamine 2,3-Dioxygenase (IDO) Related Products (165)
Related Products (165)
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Recombinant Proteins (2)
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Antibodies (2)
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Indoleamine 2,3-Dioxygenase (IDO) Isoform Comparison
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Indoximod (Standard)
0 ImagesSynonyms: 1-Methyl-D-tryptophan (Standard); NLG-8189 (Standard)Indoximod (Standard) is the analytical standard of Indoximod. This product is intended for research and analytical applications. Indoximod (1-Methyl-D-tryptophan) is an orally active indoleamine 2,3-dioxygenase (IDO) pathway inhibitor. Indoximod acts as a Trp mimetic in regulating mTOR. Indoximod is an immunometabolic adjuvant used for the research of cancer.
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GNF-PF-3777 (Standard)
0 ImagesCat. No.: HY-100687RCAS No.: 77603-42-0Synonyms: 8-Nitrotryptanthrin (Standard)GNF-PF-3777 (Standard) is the analytical standard of GNF-PF-3777 (HY-100687). This product is intended for research and analytical applications. GNF-PF-3777 (8-Nitrotryptanthrin) is a potent human indoleamine 2,3-dioxygenase 2 (hIDO2) inhibitor which significantly reduces IDO2 activity with Ki of 0.97 μM.
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(Rac)-LY-3381916 (Standard)
0 ImagesCat. No.: HY-111540ARCAS No.: 2166616-74-4Synonyms: (Rac)-IDO1-IN-5 (Standard)(Rac)-LY-3381916 (Standard) is the analytical standard of (Rac)-LY-3381916 (HY-111540A). This product is intended for research and analytical applications. (Rac)-LY-3381916 ((Rac)-IDO1-IN-5; Example 1) is a racemate of LY-3381916. LY-3381916 is a potent, selective and brain penetrated inhibitor of Indoleamine 2,3-Dioxygenase 1 (IDO1) activity, binds to apo-IDO1 lacKing heme rather than mature heme-bound IDO1.
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LW106
0 ImagesCat. No.: HY-134920CAS No.: 2116519-76-5LW106 is a selective IDO1 inhibitor with an IC50 of 1.57 μM. LW106 has no inhibitory effect on IDO2 and TDO. LW106 inhibits tumor outgrowth by limiting stroma-immune crosstalk and CSC enrichment in the tumor microenvironment. LW106 reduces subpopulation of cancer stem cells (CSCs) in xenografted tumors in which less proliferative/invasive tumor cells and more tumor cells apoptosis. LW106 can be used for the studies of lung cancer and melanoma.
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PF-06840003 (Standard)
0 ImagesCat. No.: HY-101111RCAS No.: 198474-05-4Synonyms: EOS200271 (Standard)PF-06840003 (Standard) is the analytical standard of PF-06840003 (HY-101111). This product is intended for research and analytical applications. PF-06840003 (EOS200271) is a highly selective, orally active and brain-penetrant IDO-1 inhibitor with IC50s of 0.41 μM, 0.59 μM, and 1.5 μM for hIDO-1, dIDO-1, and mIDO-1, respectively.
