Indoleamine 2,3-Dioxygenase (IDO)
Indoleamine 2, 3-dioxygenase (IDO) is an inflammatory cytokine-inducible rate-limiting enzyme of the tryptophan (Trp) catabolism, which is involved in the inhibition of intracellular pathogen replication as well as in immunomodulation. To date, three types of tryptophan-metabolizing enzymes have been identified: IDO1, IDO2 and tryptophan 2,3-dioxygenase 2.
IDO is an intracellular enzyme that is constitutively expressed in several human and mouse cells. Being present in innate immune cells, such as Mos and dendritic cells (DCs), IDO catalyzes the initial rate-limiting step of tryptophan (Trp) catabolism, thus leading to the production of immunoregulatory catabolites (collectively known as kynurenines).
The IDO gene promoter contains multiple sequence elements that confer responsiveness to proinflammatory mediators, thereby demonstrating the strong correlation between inflammation and induced IDO expression.
Indoleamine 2,3-Dioxygenase (IDO) Isoform Specific Products
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Indoleamine 2,3-Dioxygenase (IDO) Inhibitors
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Indoleamine 2,3-Dioxygenase (IDO) Antagonist
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Indoleamine 2,3-Dioxygenase (IDO) Activators
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Indoleamine 2,3-Dioxygenase (IDO) Degraders
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Indoleamine 2,3-Dioxygenase (IDO) Ligand
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IDO Proteins
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Indoleamine 2,3-Dioxygenase (IDO) Related Products (165)
Related Products (165)
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Recombinant Proteins (2)
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Antibodies (2)
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Indoleamine 2,3-Dioxygenase (IDO) Isoform Comparison
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IDO1-IN-33
0 ImagesCat. No.: HY-181947IDO1-IN-33 (Compound YC-16) is a IDO1 inhibitor (with an IC50 of 0.18 μM for IDO1 in HeLa cells). IDO1-IN-33 acts as an apo-IDO1 inhibitor by slowly and competitively displacing heme from mature holo-IDO1 and rapidly binding to the heme-binding site of immature apo-IDO1, without altering the expression level of IDO1. IDO1-IN-33 can be used for the research of hepatocellular carcinoma, non-small cell lung cancer, triple-negative breast cancer, and cervical cancer.
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IDO1-IN-32
0 ImagesCat. No.: HY-178954CAS No.: 2456309-77-4IDO1-IN-32 (Compound 45) is a potent and orally effective IDO1 inhibitor with an IC50 of 10 pM. IDO1-IN-32 exhibits significant anti-proliferative activity against Hela cells. IDO1-IN-32 can significantly inhibit tumor growth in CT26 and LCC transplanted mouse models by activating anti-tumor immunity. IDO1-IN-32 can be used for research on colon cancer and breast cancer.
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(S)-Indoximod-d3
0 ImagesSynonyms: 1-Methyl-L-tryptophan-d3; (S)-NLG-8189-d3(S)-Indoximod-d3 is the deuterium labeled (S)-Indoximod. (S)-Indoximod (1-Methyl-L-tryptophan) is an inhibitor of indoleamine 2,3-dioxygenase (IDO). (S)-Indoximod can be used for the research of cancer.
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IDO-IN-14
0 ImagesCat. No.: HY-139653CAS No.: 2568302-02-1IDO-IN-14 is an IDO inhibitor with an IC50 value of 0.6928 nM.
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IDO1-IN-16
0 ImagesCat. No.: HY-144466CAS No.: 2677054-63-4IDO1-IN-16 (I-1) is an IDO1 inhibitor targeting holo-IDO1, with an IC50 of 127 nM.
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IDO1-IN-14
0 ImagesCat. No.: HY-144274CAS No.: 3037206-49-5
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IDO1/TDO-IN-10
0 ImagesCat. No.: HY-178470IDO1/TDO-IN-10 (Compound G-14) is a dual IDO1 (EC50=3.07 μM) and TDO (EC50=9.7 μM) inhibitor. IDO1/TDO-IN-10 inhibits the conversion of tryptophan to kynurenine and modulates immune responses while reducing inflammatory reactions. IDO1/TDO-IN-10 is promising for research of cancers and inflammatory diseases.
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IDO5L (Standard)
0 ImagesCat. No.: HY-15683RCAS No.: 914471-09-3IDO5L (Standard) is the analytical standard of IDO5L. This product is intended for research and analytical applications. IDO5L is a potent indoleamine 2,3-dioxygenase (IDO) inhibitor with an IC50 of 67 nM.
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3-TYP (Standard)
0 ImagesCat. No.: HY-108331RCAS No.: 120241-79-43-TYP (Standard) is the analytical standard of 3-TYP (HY-108331). This product is intended for research and analytical applications. 3-TYP is an inhibitor of SIRT3 (IC50of 38 μM) and an inhibitor of Methionine Adenosyltransferase (MAT) 2 and Indoleamine 2,3-Dioxygenase (IDO). There may be many off-target sites for 3-TYP that need to be examined, such as NAD-dependent enzymes, including dehydrogenases.
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3-O-trans-p-Coumaroyltormentic acid
0 ImagesCat. No.: HY-N1864CAS No.: 121064-78-63-O-trans-p-Coumaroyltormentic acid is a triterpene having no cytotoxic activity. However, 3-O-cris-p-Coumaroyltormentic acid is a cytotoxic triterpene, can be isolated from the methanol extract of Goreishi (the feces of Trogopterus xanthipes Milne-Edwards). 3-O-trans-p-Coumaroyltormentic acid is an inhibitor of alpha-glucosidase and Indoleamine 2,3-Dioxygenase (IDO), and it has anti-inflammatory activity.
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LY-3381916 (Standard)
0 ImagesCat. No.: HY-111540RCAS No.: 2166616-75-5Synonyms: IDO1-IN-5 (Standard)LY-3381916 (Standard) is the analytical standard of LY-3381916 (HY-111540). This product is intended for research and analytical applications. LY-3381916 (IDO1-IN-5) is a potent, selective and brain penetrated inhibitor of IDO1 activity, binds to apo-IDO1 lacKing heme rather than mature heme-bound IDO1.
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β-Carboline-1-carboxylic acid
0 ImagesCat. No.: HY-29268CAS No.: 26052-96-0β-Carboline 1-carboxylic acid is a β-carboline alkaloid with anti-inflammatory, antifibrotic, antitumor and antibacterial activities. β-Carboline 1-carboxylic acid is the cAMP phosphodiesterase (IC50: 96 µM) and indoleamine 2, 3-dioxygenase (IDO) inhibitor. β-Carboline 1-carboxylic acid is cytotoxic to tumor cells. β-Carboline 1-carboxylic acid inhibits inflammation through the NF-κb/p65 pathway and can reverse epithelial-mesenchymal transition (EMT). In addition, β-Carboline 1-carboxylic acid has strong inhibitory activity against S. aureus (IC50: 47.70 μg/mL) and E. coli (IC50: 19.17 μg/mL).
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IDO-IN-19
0 ImagesCat. No.: HY-177557CAS No.: 2033173-20-3IDO-IN-19 (Compound I) is a free base of an imidazole-isoindole derivative. IDO-IN-19 can inhibit the activity of Indoleamine 2,3-Dioxygenase (IDO). IDO-IN-19 can block the decomposition of tryptophan and restore the function of T cells. IDO-IN-19 can be used for the researches of cancer, immunology, infection and neurological disease, such as breast cancer and Alzheimer's disease.
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Linrodostat (Standard)
0 ImagesSynonyms: BMS-986205 (Standard); ONO-7701 (Standard)Linrodostat (Standard) is the analytical standard of Linrodostat (HY-101560). This product is intended for research and analytical applications. Linrodostat (BMS-986205) is a selective and irreversible indoleamine 2,3-dioxygenase 1 (IDO1) inhibitor with an IC50 value of 1.1 nM in IDO1-HEK293 cells. Linrodostat is well tolerated with potent pharmacodynamic activity in advanced cancers.
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(S)-LY-3381916 (Standard)
0 ImagesCat. No.: HY-111540BRCAS No.: 2166616-76-6Synonyms: (S)-IDO1-IN-5 (Standard)(S)-LY-3381916 (Standard) is the analytical standard of (S)-LY-3381916 (HY-111540B). This product is intended for research and analytical applications. (S)-LY-3381916 ((S)-IDO1-IN-5; Example 1B) is an active S-isomer of LY-3381916. (S)-LY-3381916 binds to IDOL with an IC50 value less than 1.5 µΜ. LY-3381916 is a potent, selective and brain penetrated inhibitor of Indoleamine 2,3-Dioxygenase 1 (IDO1) activity, binds to apo-IDO1 lacKing heme rather than mature heme-bound IDO1.
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Linrodostat mesylate
0 ImagesCat. No.: HY-101560ACAS No.: 2221034-29-1Synonyms: BMS-986205 mesylate; ONO-7701 mesylateLinrodostat (BMS-986205) mesylate is a selective irreversible inhibitor of indoleamine 2,3-dioxygenase 1 (IDO1), which effectively inhibits IDO1-HEK293 mesylate cells with an IC50 value of 1.1 nM. Linrodostat mesylate demonstrates good pharmacological activity in advanced cancer.
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β-Lapachone (Standard)
0 ImagesSynonyms: ARQ-501 (Standard); NSC-26326 (Standard)β-Lapachone (Standard) is the analytical standard of β-Lapachone. This product is intended for research and analytical applications. β-Lapachone (ARQ-501;NSC-26326) is a naturally occurring O-naphthoquinone, acts as a topoisomerase I inhibitor, and induces apoptosis by inhibiting cell cycle progression.
