Melanocortin Receptor
MC Receptor
The melanocortin (MC) receptors represent a subfamily of G-protein-coupled receptors (GPCRs) where the different subtypes are involved in a wide range of physiological functions such as pigmentation, steroid secretion, energy homeostasis, and food intake. The melanocortin receptor (MCR) family consists of five G-protein-coupled receptors (MC1R-MC5R). MC1R controls pigmentation, MC2R is a critical component of the hypothalamic-pituitary-adrenal axis, MC3R and MC4R have a vital role in energy homeostasis and MC5R is involved in exocrine function.
MCRs are activated by a variety of neuropeptides, termed melanocortins, that include the adrenocorticotropic hormone (ACTH) andα, β and γ-melanocyte-stimulating hormones (MSHs). Melanocortins derive from post-translational processing of the common polypeptide precursor pro-opiomelanocortin, expressed mainly in the hypothalamus and pituitary.
Melanocortin Receptor Isoform Specific Products
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Melanocortin Receptor Inhibitors
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Melanocortin Receptor Agonists
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Melanocortin Receptor Antagonists
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Melanocortin Receptor Activators
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Melanocortin Receptor Modulators
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Melanocortin Receptor Inducer
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Melanocortin Receptor Degrader
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Melanocortin Receptor Controls
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Melanocortin Receptor Ligands
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Melanocortin Receptor Related Products (186)
Related Products (186)
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Antibodies (2)
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Melanocortin Receptor Isoform Comparison
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Acetyl hexapeptide-1
0 ImagesSynonyms: MelitaneAcetyl hexapeptide-1 (Melitane) is a biomimetic peptide that mimics the activity of α-melanocyte-stimulating hormone (α-MSH). Acetyl hexapeptide-1 regulates muscle contraction, thereby reducing facial expression lines. Acetyl hexapeptide-1 is one of the components of anti-aging skincare serums targeting dynamic wrinkles. Acetyl hexapeptide-1 can be used in research related to mild photoaged facial skin and premature gray hair.
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Lys-γ3-MSH(human) TFA
0 ImagesCat. No.: HY-P1210ALys-γ3-MSH(human) TFA is a melanocortin peptide derived from the C-terminal of the fragment of pro-opiomelanocortin (POMC). Lys-γ3-MSH(human) TFA potentiates the steroidogenic response of the rat adrenal to adrenocorticotrophin (ACTH). Lys-γ3-MSH(human) TFA is a potent stimulator of lipolysis with an apparent EC50 of 3.56 nM. Lys-γ3-MSH(human) TFA can activate hormone sensitive lipase (HSL) and Perilipin A resulting in lipolysis.
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MCL0020
0 ImagesMCL0020 is a potent and selective melanocortin MC4 receptor antagonist, with an IC50 of 11.63 nM. MCL0020 dose-dependently and significantly attenuates restraint stress-induced anorexia without affecting food intake.
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ACTH (7-38) (human)
0 ImagesACTH (7-38) (human) is the 7-38 fragment of human ACTH (1-39). human ACTH (1-39), known as a corticotropin inhibitory peptide (CIP), is an antagonist of the ACTH receptor and has no any corticosteroid activity.
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Undecylenoyl phenylalanine
0 ImagesCat. No.: HY-135014CAS No.: 175357-18-3Undecylenoyl phenylalanine is an antagonist for α-melanocyte-stimulating hormone (MSH) and β-adrenergic receptor (β-ADR) to reduce the melanogenesis in melanocytes, reduces hyperpigmentation and thus ameliorates melasma lesions and solar lentigines.
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PG-901
0 ImagesPG-901 is a full, selective MC5R agonist (EC50 = 0.072 nM for hMC5R). PG-901 is also a full antagonist at the hMC3R and the hMC4R (Kb: 1.0 nM and 0.53 nM, respectively). PG-901 significantly diminishes Cytokines (IL-1α, IL-1β, IL-6). PG-901 increases glucose tolerance, reduces blood glucose, decreases retinal damage.
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γ-2-MSH (41-58), amide
0 Imagesγ-2-MSH (41-58), amide is derived from γ-2-MSH. γ-2-MSH is a twelve amino acid peptide that is derived from the N-terminal fragment of proopiomelanocortin (POMC) and contains the His-Phe-Arg-Trp motif common to all melanocortin endogenous agonist ligands.
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Resomelagon acetate
0 ImagesSynonyms: AP1189 acetateResomelagon (AP1189) acetate is a potent, orally active melanocortin receptor (MR) agonist about MC1 and MC3. Resomelagon acetate induces ERK1/2 phosphorylation and Ca2+ mobilization. Resomelagon acetate has anti-inflammatory activity. Resomelagon acetate can be used for obesity and chronic inflammation research.
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Ac-c[Cys-Glu-His-d-Phe-Arg-Trp-d-Cys]-Pro-Pro-Lys-Asp-NH2
![Ac-c[Cys-Glu-His-d-Phe-Arg-Trp-d-Cys]-Pro-Pro-Lys-Asp-NH2](https://file.medchemexpress.com/product_pic/hy-p4665.gif "Click to View Ac-c[Cys-Glu-His-d-Phe-Arg-Trp-d-Cys]-Pro-Pro-Lys-Asp-NH2 Product Detail")
0 ImagesAc-c-Pro-Pro-Lys-Asp-NH2 is a selective human melanocortin 5 receptor (hMC5R) antagonist with an IC50 of 10 nM.
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Melanotan I acetate
0 ImagesSynonyms: MT-I acetate; [Nle4,D-Phe7]-α-MSH acetateMelanotan I (MT-I; [Nle4,D-Phe7]-α-MSH) acetate is an α-MSH (HY-P0252) analog, synthetic melanotropic peptide, and melanocortin receptor (MCR) agonist. Melanotan I acetate induces skin tanning by mimicking the action of α-MSH on the melanocortin 1 receptor (MC1R) in melanocytes. As an appetite suppressant, Melanotan I acetate impairs the ability of insulin to inhibit endogenous glucose production, suppresses leptin secretion from adipose tissue, and thereby reduces voluntary feed intake in ewes. Melanotan I acetate can be used in research related to UV-induced skin damage, polymorphic light eruption, ruminant feeding, and sexual dysfunction.
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Modimelanotide
0 ImagesCat. No.: HY-105305CAS No.: 926277-68-1Synonyms: ABT-719; AP-214Modimelanotide (ABT-719) is an α-melanocyte-stimulating hormone analog. Modimelanotide has high specific binding ability to melanocortin receptors (MCR1, 3, 4, 5). Modimelanotide possesses anti-inflammatory and organ-protective effects. Modimelanotide can be used in the research of diseases such as acute kidney injury.
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HS024
0 ImagesCat. No.: HY-P1215CAS No.: 212370-59-7HS024 is a selective MC4 receptor antagonist, with Kis of 0.29, 3.29, 5.45, and 18.6 nM for MC4, MC5, MC3, and MC1, respectively. HS024 increase food intake.
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hMC1R agonist 1
0 ImagesCat. No.: HY-P99004CAS No.: 3028881-87-7hMC1R agonist 1 is a selective hMC1R agonist. hMC1R agonist 1 activates adenylate cyclase to induce intracellular cAMP accumulation. hMC1R agonist 1 can be used for the research of immune-inflammatory disorders.
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Palmitoyl tetrapeptide-20 TFA
0 ImagesCat. No.: HY-P5247ASynonyms: PTP20 TFAPalmitoyl tetrapeptide-20 (PTP20) TFA is a biomimetic peptide agonist of α-MSH. Palmitoyl tetrapeptide-20 TFA promotes hair pigmentation and delays hair graying by activating the MC1-R pathway (AC50: 0.16 nM), enhancing catalase activity to reduce H2O2 accumulation, and upregulating SIRT1 activity. Palmitoyl tetrapeptide-20 TFA can be used in research on preventing hair loss and improving hair graying.
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SNT-207858
0 ImagesCat. No.: HY-11030CAS No.: 1104080-42-3SNT207858 is a selective, blood brain barrier penetrating, potent and orally active melanocortin-4 (MC-4) receptor antagonist. SNT207858 has an IC50 of 22 nM (binding) and 11 nM (function) on the MC-4 receptor.
