1. GPCR/G Protein
    Neuronal Signaling
  2. Melanocortin Receptor
  3. MCL0020

MCL0020 

Cat. No.: HY-107627
Handling Instructions

MCL0020 is a potent and selective melanocortin MC4 receptor antagonist, with an IC50 of 11.63 nM. MCL0020 dose-dependently and significantly attenuates restraint stress-induced anorexia without affecting food intake.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

MCL0020 Chemical Structure

MCL0020 Chemical Structure

CAS No. : 475498-26-1

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Description

MCL0020 is a potent and selective melanocortin MC4 receptor antagonist, with an IC50 of 11.63 nM. MCL0020 dose-dependently and significantly attenuates restraint stress-induced anorexia without affecting food intake[1].

IC50 & Target

IC50: 11.63 (MC4)

In Vitro

MCL0020 inhibited [125I][N1e4, D-Phe7]α-MSH binding to membranes of COS-1 cells with IC50 values of 11.63[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

MCL0020 attenuates swim stress-induced anxiogeniclike behavior in light/dark exploration tests in mice[1].
MCL0020 significantly reverses stress-induced anorexia in rats[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

609.72

Formula

C₃₄H₃₉N₇O₄

CAS No.
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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Product Name:
MCL0020
Cat. No.:
HY-107627
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