2. GPCR/G Protein Neuronal Signaling
  3. Melanocortin Receptor
  4. MCL0020

MCL0020 is a potent and selective melanocortin MC4 receptor antagonist, with an IC50 of 11.63 nM. MCL0020 dose-dependently and significantly attenuates restraint stress-induced anorexia without affecting food intake.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

MCL0020 Chemical Structure

MCL0020 Chemical Structure

CAS No. : 475498-26-1

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Based on 1 publication(s) in Google Scholar

MCL0020 Related Antibodies

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  • Biological Activity

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Description

MCL0020 is a potent and selective melanocortin MC4 receptor antagonist, with an IC50 of 11.63 nM. MCL0020 dose-dependently and significantly attenuates restraint stress-induced anorexia without affecting food intake[1].

IC50 & Target

IC50: 11.63 (MC4)
In Vitro

MCL0020 inhibited [125I][N1e4, D-Phe7]α-MSH binding to membranes of COS-1 cells with IC50 values of 11.63[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

MCL0020 Related Antibodies
In Vivo

MCL0020 attenuates swim stress-induced anxiogeniclike behavior in light/dark exploration tests in mice[1].
MCL0020 significantly reverses stress-induced anorexia in rats[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

609.72

Formula

C34H39N7O4
CAS No.
Appearance

Solid

Color

White to off-white

Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (205.01 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.6401 mL 8.2005 mL 16.4010 mL
5 mM 0.3280 mL 1.6401 mL 3.2802 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.6401 mL 8.2005 mL 16.4010 mL 41.0024 mL
5 mM 0.3280 mL 1.6401 mL 3.2802 mL 8.2005 mL
10 mM 0.1640 mL 0.8200 mL 1.6401 mL 4.1002 mL
15 mM 0.1093 mL 0.5467 mL 1.0934 mL 2.7335 mL
20 mM 0.0820 mL 0.4100 mL 0.8200 mL 2.0501 mL
25 mM 0.0656 mL 0.3280 mL 0.6560 mL 1.6401 mL
30 mM 0.0547 mL 0.2733 mL 0.5467 mL 1.3667 mL
40 mM 0.0410 mL 0.2050 mL 0.4100 mL 1.0251 mL
50 mM 0.0328 mL 0.1640 mL 0.3280 mL 0.8200 mL
60 mM 0.0273 mL 0.1367 mL 0.2733 mL 0.6834 mL
80 mM 0.0205 mL 0.1025 mL 0.2050 mL 0.5125 mL
100 mM 0.0164 mL 0.0820 mL 0.1640 mL 0.4100 mL
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MCL0020 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MCL0020475498-26-1MCL 0020MCL-0020Melanocortin ReceptorMC Receptordose-dependentlystress-inducedanorexiaCOS-1Inhibitorinhibitorinhibit

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