2. GPCR/G Protein Neuronal Signaling
  3. Melanocortin Receptor
  4. MCL0020

MCL0020 

Cat. No.: HY-107627
Handling Instructions

MCL0020 is a potent and selective melanocortin MC4 receptor antagonist, with an IC50 of 11.63 nM. MCL0020 dose-dependently and significantly attenuates restraint stress-induced anorexia without affecting food intake.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

MCL0020 Chemical Structure

MCL0020 Chemical Structure

CAS No. : 475498-26-1

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MCL0020 Related Antibodies

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Description

MCL0020 is a potent and selective melanocortin MC4 receptor antagonist, with an IC50 of 11.63 nM. MCL0020 dose-dependently and significantly attenuates restraint stress-induced anorexia without affecting food intake[1].

IC50 & Target

IC50: 11.63 (MC4)
In Vitro

MCL0020 inhibited [125I][N1e4, D-Phe7]α-MSH binding to membranes of COS-1 cells with IC50 values of 11.63[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

MCL0020 Related Antibodies
In Vivo

MCL0020 attenuates swim stress-induced anxiogeniclike behavior in light/dark exploration tests in mice[1].
MCL0020 significantly reverses stress-induced anorexia in rats[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

609.72

Formula

C34H39N7O4
CAS No.
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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MCL0020 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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Keywords:

MCL0020475498-26-1MCL 0020MCL-0020Melanocortin ReceptorMC Receptordose-dependentlystress-inducedanorexiaCOS-1Inhibitorinhibitorinhibit

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