P2X Receptor
-
P2X Receptor Related Products (73)
Related Products (73)
-
8-Bromo-ATP
0 ImagesCat. No.: HY-134262CAS No.: 23567-97-7Synonyms: 8-Bromoadenosine 5'-triphosphate; 8-Br-ATP8-Bromo-ATP (8-Bromoadenosine 5'-triphosphate), an ATP analogue, is a purinergic P2X receptor agonist. 8-Bromo-ATP shows cytotoxic to multiple myeloma cells with an IC50 of 23.1 μM.
-
P2X7 receptor antagonist-5
0 ImagesCat. No.: HY-162951CAS No.: 3046388-16-0P2X7 receptor antagonist-5 (compund 13a) is a potent, orally active and long-lasting P2X7 receptor antagonist.
-
Eperisone
0 ImagesCat. No.: HY-128891CAS No.: 64840-90-0Eperisone ((±)-Eperisone) is an antispasmodic agent and centrally acting muscle relaxant useful in the study of diseases characterized by muscle stiffness and pain. Eperisone acts by relaxing skeletal and vascular smooth muscle, resulting in vasodilation, decreased muscle tone, improved circulation, and inhibition of pain reflexes. Eperisone is also a potent P2X7 receptor antagonist.
-
P2X receptor-1
0 ImagesCat. No.: HY-139627CAS No.: 3051864-35-5P2X receptor-1 is a potential inhibitor of P2X receptor for the research of pain and inflammation.
-
MRS 2219
0 ImagesCat. No.: HY-102063CAS No.: 14141-47-0Synonyms: Pyridoxol, cyclic 3,4-hydrogen phosphateMRS 2219 (Pyridoxol) is a selective pharmacological probe of P2X1 receptor. MRS 2219 selectively potentiated ATP-evoked responses at P2X1 receptors with an EC50 of 5.9 μM.
-
α,β-Methylene-ATP
0 ImagesCat. No.: HY-134440ACAS No.: 7292-42-4α,β-Methylene-ATP is an agonist of P2X1 and P2X3 receptors and can cross the blood-brain barrier. α,β-Methylene-ATP can trigger a reflex pressor response by activating P2X receptors in peripheral muscles and the central locus coeruleus (LC); this effect can be blocked by the P2X antagonist PPADS (HY-108960). α,β-Methylene-ATP also activates noradrenergic neurons in the central locus coeruleus, mediating antinociceptive effects; this effect can be attenuated by the locus coeruleus damaging agent DSP-4 (HY-103210/HY-121602). α,β-Methylene-ATP can be used to study the pathological mechanisms of neuropathic pain, cardiovascular reflex regulation, and antinociceptive effects of the central nervous system.
-
P2X2/3 modulator-1
0 ImagesCat. No.: HY-153548CAS No.: 1217483-98-1P2X2/3 modulator-1 (Compound 46) is a P2X2/3 modulator. P2X2/3 modulator-1 can be used in the study of pain, central nervous system disorders and inflammation.
-
NP-1815-PX
0 ImagesCat. No.: HY-150270CAS No.: 1239578-79-0NP-1815-PX is an orally active dual inhibitor of P2X4 and prostaglandin TP receptors, with an IC50 of 0.26 μM against human P2X4 receptors. NP-1815-PX specifically inhibits ATP-mediated prostaglandin production, TP receptor-induced calcium elevation, and the canonical/non-canonical NLRP3 inflammasome signaling pathway. NP-1815-PX selectively blocks smooth muscle contractions induced by ATP, U46619 (HY-108566) and prostaglandin F2α. NP-1815-PX not only produces anti-allodynic effects in vivo, but also significantly alleviates symptoms of DNBS (HY-W324435)-induced colitis (such as weight loss and tissue damage). NP-1815-PX exerts anti-inflammatory effects by downregulating IL-1β levels and Caspase-1 activity. NP-1815-PX is used in studies related to asthma and inflammatory bowel disease (colitis).
-
AZD9056
0 ImagesCat. No.: HY-19427CAS No.: 345304-65-6AZD9056 is a P2X7 purinergic receptor antagonist with anticancer activity. AZD9056 can inhibit the invasion and metastasis of cancer stem cells.
-
Gefapixant citrate (Standard)
0 ImagesSynonyms: MK-7264 citrate (Standard); AF-219 citrate (Standard)Gefapixant (citrate) (Standard) is the analytical standard of Gefapixant (citrate) (HY-101588A). This product is intended for research and analytical applications. Gefapixant citrate is an orally active and potent purinergic P2X3 receptor (P2X3R) antagonist, with IC50 values of ~30 nM versus recombinant hP2X3 homotrimers and 100-250 nM at hP2X2/3 heterotrimeric receptors. Gefapixant citrate can be used for the research of chronic cough and knee osteoarthritis.
-
Ap4G
0 ImagesCat. No.: HY-134370CAS No.: 10527-46-5Ap4G is a dinucleoside polyphosphate compound with vasoconstrictor activity. Ap4G regulates vasoconstriction through P2 receptors, especially P2X receptors, and is an important tool for studying vascular physiology and pathology.
-
5-BDBD (Standard)
0 ImagesCat. No.: HY-101911RCAS No.: 768404-03-15-BDBD (Standard) is the analytical standard of 5-BDBD (HY-101911). This product is intended for research and analytical applications. 5-BDBD, a potent and selective P2X4 receptor antagonist, inhibits rP2X4R-mediated currents, with an IC50 of 0.75 μM. 5-BDBD completely blocks the basal and acute hyperalgesia induced by nitroglycerin (NTG).
-
Lappaconine
0 ImagesCat. No.: HY-129731CAS No.: 23943-93-3Lappaconine is a diterpenoid alkaloid. Lappaconine can be used for α-hydroxylation of β-oxo esters.
-
PSB-12062 (Standard)
0 ImagesCat. No.: HY-101910RCAS No.: 55476-47-6Synonyms: N-(p-Methylphenylsulfonyl)phenoxazine (Standard)
-
A 438079 hydrochloride (Standard)
0 ImagesA 438079 (hydrochloride) (Standard) is the analytical standard of A 438079 (hydrochloride). This product is intended for research and analytical applications. A 438079 (hydrochloride) is a potent, and selective P2X7 receptor antagonist with pIC50 of 6.9.
-
A 438079 (Standard)
0 ImagesA 438079 (Standard) is the analytical standard of A 438079. This product is intended for research and analytical applications. A 438079 is a potent, and selective P2X7 receptor antagonist with pIC50 of 6.9.
-
AF-353 (Standard)
0 ImagesCat. No.: HY-14483RCAS No.: 865305-30-2Synonyms: Ro-4 (Standard)AF-353 (Standard) is the analytical standard of AF-353. This product is intended for research and analytical applications. AF-353 (Ro-4) is a potent, selective and orally bioavailable P2X3/P2X2/3 receptor antagonist, with a pIC50 of 8.0 for both human and rat P2X3, and with a pIC50 of 7.3 for human P2X2/3.
-
Gardenoside (Standard)
0 ImagesCat. No.: HY-N1478RCAS No.: 24512-62-7Gardenoside is an orally active natural compound found in Gardenia fruits. Gardenoside reliefs chronic constriction injury (CCI)-induced neuropathic pain by regulating the P2X3 and P2X7 receptors. Gardenoside has an inhibitory effect on free fatty acids (FFA)-induced cellular steatosis. Gardenoside reduces reactive oxygen species (ROS). Gardenoside can be used for anti-inflammatory, antinociceptive and hepatoprotective study.
-
AZ10606120 dihydrochloride (Standard)
0 ImagesCat. No.: HY-108669RCAS No.: 607378-18-7AZ10606120 dihydrochloride (Standard) is the analytical standard of AZ10606120 (dihydrochloride) (HY-108669). This product is intended for research and analytical applications. AZ10606120 dihydrochloride is a selective, high affinity antagonist for P2X7 receptor (P2X7R) at human and rat with an IC50 of about 10 nM. AZ10606120 dihydrochloride is little or no effect at other P2XR subtypes. AZ10606120 dihydrochloride has anti-depressant effects and reduces tumour growth.
-
ITH15004
0 ImagesCat. No.: HY-156986CAS No.: 2600675-12-3ITH15004 is a CNS-penetrated P2X7 antagonist, used for the study of neurodegenerative diseases.
