Radionuclide-Drug Conjugates (RDCs)
Radionuclide-drug conjugates (RDCs) are one of the most promising development directions for nuclear drug targeted therapy. RDC is composed of targeting element, linker, chelate and radioactive isotope. RDC has advantages in early tumor diagnosis, treatment and postoperative tumor evaluation. The same ligand can be connected to nuclides used for disease diagnosis and treatment respectively, promoting the integration of diagnosis and treatment of RDC drugs. This entry provides molecular intermediates that can be used in the synthesis and research of RDC.
Radionuclide-Drug Conjugates (RDCs) Isoform Specific Products
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Radionuclide-Drug Conjugates (RDCs) Related Products (230)
Related Products (230)
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Radionuclide-Drug Conjugates (RDCs) Isoform Comparison
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NP1
0 ImagesCat. No.: HY-P11859NP1 is a NOTA-chelated linear precursor based on the ROR1-targeting peptide. After labeling with [18F]AlF, NP1 yields [18F]AlF-NP1, a PET imaging probe with excellent ROR1 specificity (KD = 141.7 nM), rapid tumor uptake and high target-to-background ratio, which is suitable for non-invasive visualization of various ROR1-overexpressing tumors.
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MMA-NODAGA TFA
0 ImagesCat. No.: HY-160607APurity: 98.02%MMA-NODAGA TFA is a chelator for site-specific labeling of targeting proteins containing unpaired cysteine. MMA-NODAGA TFA can be used to conjugate with exosome and 64Cu in image with positron emission tomography (PET).
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Flortanidazole
0 ImagesCat. No.: HY-113837CAS No.: 1070878-63-5Flortanidazole is a derivative of 2-Nitroimidazole (HY-N0195). Under hypoxic conditions, Flortanidazole accumulates in hypoxic tissues through the reduction of 2-nitroimidazole and the retention of reactive intermediates by viable hypoxic cells. Flortanidazole binds to intracellular macromolecules under hypoxic conditions, thereby enabling quantification of tumor hypoxia. [18F]Flortanidazole, formed after labeling Flortanidazole with 18F, is a hypoxic PET imaging tracer and prognostic imaging biomarker. Flortanidazole can be used in the study of non-small cell lung cancer and colorectal cancer.
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DOTA-bis(tert-butyl)ester
0 ImagesDOTA-bis(tert-butyl)ester is a DOTA-based metal chelator that can bind to radionuclides and is used to prepare radionuclide conjugates (RDCs). DOTA-bis(tert-butyl)ester can be conjugated with different salts to form different metal chelators, such as (HY-B1244) hydrochloride to obtain DOTA-MN2. DOTA-MN2 can be reacted with [67]Ga-citrate to obtain radiolabeling. When (67)Ga-DOTA-MN2 is incubated in phosphate buffer solution or mouse plasma for 24 hours, it does not undergo significant decomposition. In the biodistribution experiment of NFSa tumor mice, it has high tumor uptake and rapid plasma clearance, and is a good material for SPECT and PET studies.
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Guraxetan-NH-PEG3-TFP ester
0 ImagesCat. No.: HY-167987CAS No.: 2716184-56-2Guraxetan-NH-PEG3-TFP ester (Fig.3) is a chelating agent and linker conjugate that can be used in the synthesis of radiopharmaceuticals.
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Ethylenediaminetetra(methylenephosphonic acid) sodium
0 ImagesCat. No.: HY-W008951ACAS No.: 7651-99-2Synonyms: EDTMP sodiumEthylenediaminetetramethylenephosphonic acid (EDTMP) sodium is a bone-targeted chelating agent. Ethylenediaminetetramethylenephosphonic acid sodium‘s phosphonic acid groups possess a unique ability to bind with high affinity to hydroxyapatite in bone, and can form radioactive compounds with 153Sm and 177Lu. Ethylenediaminetetramethylenephosphonic acid sodium is used to study palliative therapy for pain associated with multiple bone metastatic cancers.
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BCN-DOTA-GA
0 ImagesCat. No.: HY-164577CAS No.: 2416980-98-6BCN-DOTA-GA is a cyclooctyne-linked DOTA chelator that can be labeled with radioactive zirconium-89 and used as a radionuclide-labeled drug conjugate (RDC) to target specific biomolecules, cells or tissues.
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2-Aminoethyl-mono-amide-DOTA-tris(tBu ester) (Standard)
0 ImagesCat. No.: HY-100138RCAS No.: 173308-19-52-Aminoethyl-mono-amide-DOTA-tris(tBu ester) (Standard) is the analytical standard of 2-Aminoethyl-mono-amide-DOTA-tris(tBu ester) (HY-100138). This product is intended for research and analytical applications. 2-Aminoethyl-mono-amide-DOTA-tris(tBu ester) is a metal chelator precursor containing a DOTA macrocyclic structure. DOTA can form highly stable complexes with metal ions (such as 68Ga, 177Lu) through four nitrogen atoms and four carboxylic acid groups to mediate targeted delivery of radionuclides. The tert-butyl ester group (tBu ester) of 2-Aminoethyl-mono-amide-DOTA-tris(tBu ester) also protects the carboxylic acid group during synthesis, and forms a free carboxyl group after deprotection reaction for coupling with targeting molecules (such as antibodies, peptides). 2-Aminoethyl-mono-amide-DOTA-tris(tBu ester) may be combined with tumor pre-targeting systems through bioorthogonal reactions (such as reverse electron demand Diels-Alder reaction) to study radioactive imaging or therapy of tumor tissues, and is mainly used in tumor pre-targeting research in the field of nuclear medicine.
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Edotreotide (Standard)
0 ImagesCat. No.: HY-106033RCAS No.: 204318-14-9Synonyms: DOTATOC (Standard); SDZ-SMT 487 (Standard); SMT 487 (Standard)Edotreotide (Standard) is the analytical standard of Edotreotide (HY-106033). This product is intended for research and analytical applications. Edotreotide is a ligand that selectively targets SSTR2 and can competitively bind to the receptor. Edotreotide mediates the targeted delivery, while modificated with radionuclides (such as 90Y, 177Lu, and 68Ga) to SSTR-positive tumors and induces tumor cell apoptosis by releasing β rays. Edotreotide has strong tumor targeting and precise killing activity. Edotreotide is used in the synthesis of radionuclide-drug conjugates (RDCs) and is widely used in the field of neuroendocrine tumors (such as metastatic carcinoids, lung and thymus NETs).
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Aldoview
0 ImagesAldoView (Compound 3) is an intermediate. AldoView can be labeled with fluorine-18 to synthesize [18F]AldoView. [18F]AldoView is a highly selective aldosterone synthase PET imaging agent. AldoView can be used in imaging studies of primary aldosteronism.
