Renin Inhibitor

Renin-IN-4 is a Renin inhibitor. Renin-IN-4 can be used for the research of cardiovascular disease.

Ciprokiren (Ro 44-9375) is a Renin inhibitor with IC₅₀s of 0.07 and 0.65 nM for hRenin in buffer and plasma, respectively. Ciprokiren be applied transdermally with similar hemodynamic effects without decrease of plasma renin activity or plasma immunoreactive angiotensin II. Ciprokiren has antihypertensive efficacy and can be used for hypertension research.

VTP-27999 is an alkyl amine Renin inhibitor; VTP-27999 is useful for Hypertension and End-Organ Diseases.

CGP 29287 is a specific renin inhibitor.

CP-85339 is a tetrapeptide renin inhibitor.

SQ 30774 is a renin (renin) inhibitor. SQ 30774 has potent in vitro inhibitory effects in primates but not in rats, pigs, or dogs. And imidazolinol renin inhibitors also inhibit PRA and reduce arterial blood pressure in vivo.

Imarikiren (AK-272 free base) is an orally active, selective Renin inhibitor with an IC₅₀ value of 2.1 nM against h-Renin. Imarikiren blocks the conversion of Angiotensinogen to Angiotensin I and reduces mean arterial pressure by inhibiting Angiotensin II that binds to AT1. Imarikiren alleviates myocardial hypertrophy and pulmonary congestion, exerting cardioprotective effects. Imarikiren can be used in research related to hypertension and heart failure.

Terlakiren (CP-80,794) is an orally active inhibitor of renin. Terlakiren inhibits the efficacy of human renin with an IC₅₀ value of 0.7 nM. Terlakiren has potential applications in hypertension.

L-363564 is a renin inhibitor. L-363564 can be used in cardiovascular disease related research.

Chlorothiazide sodium is an orally active diuretic and anti-hypertensive agent.

CGP 44099 is a renin inhibitor. CGP 44099 can be used to study the ischemic injury and reperfusion arrhythmias in rat hearts.

Aliskiren-d₆ (hydrochloride) is is deuterium labeled Aliskiren, which is a direct renin inhibitor.

H-77 is a selective Renin inhibitor with an IC₅₀ of 1.2 μM. H-77 causes dose-dependent decreases in plasma angiotensin I, plasma angiotensin II, and mean arterial pressure in sodium-depleted conscious beagle dogs. H-77 does not alter blood pressure or plasma angiotensin II levels in conscious chronically cannulated rats. H-77 can be used in studies related to the physiological and pathological states of the renin-angiotensin system.

SR 42128 is a potent renin inhibitor. SR 42128 potently inhibits primate renins whereas other animal renins are much less inhibited.

Renin inhibitor peptide,rat is a biological active peptide. (A specific rat renin inhibitor.)

Ditekiren (U 71038) is a pseudohexapeptide renin inhibitor. Renin is an enzyme that plays a crucial role in regulating blood pressure and fluid balance. By inhibiting the activity of renin, ditekiren slows down the formation of angiotensin II, a potent vasoconstrictor that can raise blood pressure. Ditekiren can be used for research in the field of blood pressure reduction.

PD 134922 is a potent renin and HIV-1 protease inhibitor with an IC₅₀ of 15 nM against HIV-1 protease.

U80215, a dansylated peptide, is a competitive human renin inhibitor with the IC₅₀ of 2.3 μM. U80215 shows excitation and emission maxima at 340 and 530 nm.

Aliskiren-d₆-1 hemifumarate (CGP 60536-d₆-1 hemifumarate) is the deuterium labeled Aliskiren hemifumarate (HY-12177). Aliskiren is an orally active, highly potent and selective renin inhibitor, with IC₅₀ of 1.5 nM. Aliskiren can be used for the research of hypertension, cardiovascular diseases and cancer cachexia.

MK-8141 (ACT-077825) is a renin inhibitor that significantly increases levels of immunoreactive renin (ir-AR) by sevenfold but does not result in sustained reductions in blood renin activity (PRA). This study evaluated the antihypertensive efficacy of MK-8141 in hypertensive disease. Despite its effects on ir-AR, MK-8141 (ACT-077825) did not produce significant blood pressure-lowering effects in the absence of sustained PRA inhibition.