STING
Stimulator of Interferon Genes; TMEM173; MITA; ERIS; MPYS
Stimulator of interferon genes (STING) is an integral ER-membrane protein that can be activated by 2'3'-cGAMP synthesized by cyclic guanosine monophosphate-adenosine monophosphate synthase (cGAS) upon binding of double-stranded DNA. It activates interferon (IFN) and inflammatory cytokine responses to defend against infection by microorganisms.
STING is a key cytosolic receptor for small nucleotides and plays a key role in anticancer and antiviral immunity. STING signaling pathway is also a critical link between innate and adaptive immunity, and induces anti-tumor immune responses. STING agonists, such as endogenous cyclic dinucleotide (CDN) cyclic GMP-AMP (cGAMP), have been used in diverse research for immunogenic tumor clearance, antiviral treatments and vaccine adjuvants.
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STING Inhibitors
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STING Agonists
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STING Antagonists
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STING Activators
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STING Modulators
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STING Degraders
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STING Controls
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STING Ligands
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STING Related Products (271)
Related Products (271)
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Antibodies (13)
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2’3’-c-di-AM(PS)2 (Rp,Rp) disodium salt (Standard)
0 ImagesCat. No.: HY-12885ARCAS No.: 1638750-95-4Synonyms: ADU-S100 disodium salt (Standard); MIW815 disodium salt (Standard); ML RR-S2 CDA disodium salt (Standard)2’3’-c-di-AM(PS)2 (Rp,Rp) disodium salt (Standard) is the analytical standard of 2’3’-c-di-AM(PS)2 (Rp,Rp) disodium salt (HY-12885A). This product is intended for research and analytical applications. 2’3’-c-di-AM(PS)2 (Rp,Rp) disodium salt (ADU-S100 disodium salt) is an activator of stimulator of interferon genes (STING).
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H-151 (Standard)
0 ImagesCat. No.: HY-112693RCAS No.: 941987-60-6H-151 (Standard) is the analytical standard of H-151 (HY-112693). This product is intended for research and analytical applications. H-151 is a potent, selective and covalent antagonist of STING that has noteworthy inhibitory activity both in cells and in vivo. H-151 reduces TBK1 phosphorylation and suppresses STING palmitoylation. H-151 can be used for the research of autoinflammatory disease.
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Ulevostinag (isomer 3)
0 ImagesCat. No.: HY-139586CCAS No.: 2082743-98-2Synonyms: MK-1454 (isomer 3)Ulevostinag (isomer 3) (example 246) is a potent cyclic dinucleotide agonist stimulator of interferon genes (STING). Ulevostinag (isomer 3) plays an important role in anti-tumor research.
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Cyclic-di-GMP sodium
0 ImagesCat. No.: HY-107780ASynonyms: c-di-GMP sodium; cyclic diguanylate sodium; 5GP-5GP sodiumCyclic-di-GMP sodium is a STING agonist and a bacterial second messenger that coordinates different aspects of bacterial growth and behavior, including motility, virulence, biofilm formation, and cell cycle progression. Cyclic-di-GMP sodium has anti-cancer cell proliferation activity and also induces elevated CD4 receptor expression and cell cycle arrest. Cyclic-di-GMP sodium can be used in cancer research.
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SN-011 (Standard)
0 ImagesCat. No.: HY-145010RCAS No.: 2249435-90-1SN-011 (Standard) is the analytical standard of SN-011 (HY-145010). This product is intended for research and analytical applications. SN-011 is a potent and selective mouse and human STING inhibitor, with an IC50 of 76 nM for STING signaling. SN-011 competes with cyclic dinucleotide (CDN) for the binding pocket of the STING dimer, blocKing CDN binding and STING activation. SN-011 can be used for the research of STING-driven autoimmune and inflammatory disease.
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Ulevostinag (isomer 4)
0 ImagesCat. No.: HY-139586DCAS No.: 2082743-97-1Synonyms: MK-1454 (isomer 4)Ulevostinag isomer 4 (MK-1454 isomer 4) is the isomer of Ulevostinag. Ulevostinag is a STING agonist.
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Vomicine (Standard)
0 ImagesVomicine (Standard) is the analytical standard of Vomicine. This product is intended for research and analytical applications. Vomicine modulates cGAS-STING-TBK1 signaling pathway, and exhibits anti-inflammatory activity. Vomicine is an alkaloid that can be isolated from Strychnos nux-vomica seeds.
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Pyroptosis inducer-1
0 ImagesCat. No.: HY-189386CAS No.: 3081319-75-4Pyroptosis inducer-1 is a pyroptosis inducer. Pyroptosis inducer-1 promotes STING phosphorylation, NF-κB activation, caspase-1-dependent pyroptosis, GSDMD cleavage, mitochondrial membrane potential disruption, ROS production, S phase cell cycle arrest, ER stress, calcium release, and immunogenic cell death accompanied by CRT exposure, HMGB1 release, and ATP secretion. Pyroptosis inducer-1 enters cancer cells via endocytosis and accumulates in mitochondria and endoplasmic reticulum. Pyroptosis inducer-1 increases dendritic cells and CD8+ T cells while decreasing regulatory T cells. Pyroptosis inducer-1 can be used for breast cancer research.
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Matairesinol monoglucoside
0 ImagesMatairesinol monoglucoside is a STING activator. Matairesinol monoglucoside modulates the STING-TBK1-IRF3 signaling axis, promotes STING transcriptional expression, increases TBK1 and IRF3 phosphorylation. Matairesinol monoglucoside induces IFN-α and IFN-β production, reduces HBV DNA, HBsAg, and HBeAg expression. Matairesinol monoglucoside can be used for the research of hepatitis b virus (hbv) infection.
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diABZI STING agonist-1 (Standard)
0 ImagesCat. No.: HY-112921ARCAS No.: 2138299-33-7diABZI STING agonist-1 (Standard) is the analytical standard of diABZI STING agonist-1 (HY-112921A). This product is intended for research and analytical applications. diABZI STING agonist-1 is a tautomerism of diABZI STING agonist-1 tautomerism (HY-112921). diABZI STING agonist-1 is a selective stimulator of interferon genes (STING) receptor agonist, with EC50s of 130, 186 nM for human and mouse, respectively.
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PDIC-NC
0 ImagesCat. No.: HY-169483CAS No.: 2633013-75-7PDIC-NC is a STING agonist. PDIC-NC is cytotoxic to tumor cells and induces ROS explosion, apoptosis and autophagy. PDIC-NC has lung specific distribution and can be used in the study of lung cancer.
