Sodium Channel
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Sodium Channel Inhibitors
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Sodium Channel Agonists
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Sodium Channel Activators
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Sodium Channel Modulators
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Sodium Channel Ligands
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Sodium Channel Related Products (629)
Related Products (629)
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Indecainide hydrochloride
0 ImagesCat. No.: HY-16259CAS No.: 73681-12-6Synonyms: Ricainide hydrochloride; LY 135837Indecainide hydrochloride is a potent and orally active class I local anesthetic antiarrhythmic agent. Indecainide hydrochloride has Na+-channel-blocking activity.
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Mepivacaine-d3
0 ImagesMepivacaine-d3 is the deuterium labeled Mepivacaine. Mepivacaine is an amide-type local anesthetic agent. Mepivacaine binds to specific voltage-gated sodium ion channels in neuronal cell membranes, which inhibits both sodium influx and membrane depolarization.
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Ranolazine-d5
0 ImagesCat. No.: HY-B0280SCAS No.: 1092804-87-9Synonyms: CVT 303-d5; RS 43285-003-d5Ranolazine-d5 is the deuterium labeled Ranolazine. Ranolazine (CVT 303) is an anti-angina drug that achieves its effects by inhibiting the late phase of inward sodium current (INa and IKr with IC50 values of 6 μM and 12 μM, respectively) without affecting heart rate or blood pressure (BP). Ranolazine is also a partial fatty acid oxidation (FAO) inhibitor. Antianginal agent.
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Nav1.8-IN-7
0 ImagesCat. No.: HY-160588CAS No.: 2761181-58-0Nav1.8-IN-7 (Example 116) is a selective Nav1.8 inhibitor. Nav1.8-IN-7 shows an inhibition of >50% with 100 nM for Nav1.8. Nav1.8-IN-7 inhibits hERG with an IC50 of 15.6 μM. Nav1.8-IN-7 has the potential for pain research.
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6-Iodoamiloride
0 ImagesCat. No.: HY-155017CAS No.: 60398-23-46-Iodoamiloride is a potent acid-sensing ion channel 1 (ASIC1) inhibitor with an IC50 of 88 nM. 6-Iodoamiloride inhibits ASIC3-mediated currents from rat dorsal root ganglion neurons with an IC50 of 230 nM.
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Fluphenazine dihydrochloride (Standard)
0 ImagesFluphenazine (dihydrochloride) (Standard) is the analytical standard of Fluphenazine (dihydrochloride). This product is intended for research and analytical applications. Fluphenazine dihydrochloride is a potent, orally active phenothiazine-based dopamine receptor antagonist. Fluphenazine dihydrochloride blocks neuronal voltage-gated sodium channels. Fluphenazine dihydrochloride acts primarily through antagonism of postsynaptic dopamine-2 receptors in mesolimbic, nigrostriatal, and tuberoinfundibular neural pathways. Fluphenazine dihydrochloride can antagonize Methylphenidate-induced stereotyped gnawing and inhibit climbing behaviour in mice. Fluphenazine dihydrochloride can be used for researching psychosis and painful peripheral neuropathy associated with diabetes and has potential to inhibit SARS-CoV-2.
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Atomoxetine-d7 hydrochloride
0 ImagesCat. No.: HY-17385S1Synonyms: Tomoxetine-d7 hydrochloride; (R)-Tomoxetine-d7 hydrochlorideAtomoxetine-d7 hydrochloride (Tomoxetine-d7 hydrochloride) is the deuterium labeled Atomoxetine hydrochloride (HY-17385). Atomoxetine (Tomoxetine) hydrochloride is a selective noradrenaline reuptake inhibitor with Ki values of 5 nM, 77 nM and 1451 nM for norepinephrine (NE), serotonin (5-HT) and dopamine (DA) transporters, respectively. Atomoxetine hydrochloride is a potent Na+ channels (VGSCs) blocker. Atomoxetine hydrochloride can be used for attention-deficit hyperactivity disorder (ADHD) research.
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Pramocaine-d9 hydrochloride
0 ImagesCat. No.: HY-B1319S1Synonyms: Pramoxine-d9 hydrochloridePramocaine-d9 (Pramoxine-d9) hydrochloride is the d9-labeled Pramocaine hydrochloride (HY-B1319). Pramocaine hydrochloride is a topical surface anesthetic and antipruritic agent. Pramocaine hydrochloride reversibly inhibits voltage-gated sodium channel, reduces transmembrane permeability of sodium ions, stabilizes cell membranes, prevents depolarization, blocks action potential conduction, and inhibits peripheral slow C-fiber pathways associated with pain, pruritus and thermoception. Pramocaine hydrochloride can be used in research related to chronic pruritus, renal pruritus, atopic dermatitis, xerotic pruritus, uremic pruritus, and cutaneous hyperalgesia/pain.
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BDF 9148
0 ImagesCat. No.: HY-116119CAS No.: 120838-62-2BDF 9148 is a sodium-channel activator with antiarrhythmic properties that produces a significant CAMP-independent positive inotropic effect in left ventricular myocardium from failing hearts. BDF 9148 is promising for research of myocardial failure.
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PptT-IN-4
0 ImagesCat. No.: HY-149305CAS No.: 2948309-57-5PptT-IN-4 (Compound 3a) is a PptT inhibitor (IC50: 0.71 μM). PptT-IN-4 inhibits Mtb H37Rv with a MIC value of 42 μM. PptT-IN-4 also inhibits hERG, hCav1.2, and hNav1.5 channels with IC50s of 11 μM, 8.1 μM, 6.9 μM respectively.
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E-0747
0 ImagesCat. No.: HY-106749CAS No.: 99599-78-7E-0747 is an antiarrhythmic drug that inhibits arrhythmias by inhibiting Na[+] channels in cardiomyocytes.
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Ethacizine
0 ImagesCat. No.: HY-131987CAS No.: 33414-33-4Ethacizine is an antiarrhythmic agent with inhibitory activity on sodium channels.
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Leporin A
0 ImagesCat. No.: HY-N16421CAS No.: 140381-54-0Leporin A is an insecticide. Leporin A binds to GABA receptors or sodium channels to disrupt neurotransmission.
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Halofuginone hydrochloride (Standard)
0 ImagesCat. No.: HY-N1584BRCAS No.: 1217623-74-9Synonyms: RU-19110 hydrochloride (Standard)Halofuginone hydrochloride (Standard) (RU-19110 hydrochloride (Standard)) is the analytical standard of Halofuginone hydrochloride (HY-N1584B). This product is intended for research and analytical applications. Halofuginone hydrochloride (RU-19110 hydrochloride), a Febrifugine derivative, is a competitive prolyl-tRNA synthetase inhibitor with a Ki of 18.3 nM. Halofuginone hydrochloride is a specific inhibitor of type-I collagen synthesis and attenuates osteoarthritis (OA) by inhibition of TGF-β activity. Halofuginone hydrochloride is also a potent pulmonary vasodilator by activating Kv channels and blocking voltage-gated, receptor-operated and store-operated Ca2+ channels. Halofuginone hydrochloride has anti-malaria, anti-inflammatory, anti-cancer, anti-fibrosis effects.
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Sodium Channel inhibitor 5
0 ImagesCat. No.: HY-163637Sodium Channel inhibitor 5 (compound 7d) is a potent inhibitor of sodium channel, with the IC50 of 2.7 μM. Sodium Channel inhibitor 5 plays an important role in antiarrhythmic research.
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BGC-201259
0 ImagesCat. No.: HY-107047CAS No.: 444667-97-4Synonyms: RS-1259BGC-201259 (RS-1259) is an orally active inhibitor that simultaneously targets acetylcholinesterase (AChE) (IC50 = 101 nM) and serotonin transporter (SERT) (IC50 = 42 nM). BGC-201259 inhibits 5-HT receptor with an IC50 of 90 nM. BGC-201259 exhibits strong weak activity against the NA transporter (IC50 = 7.7 μM), L-type calcium channel (IC50 = 3.6 μM), σ receptor (IC50 = 2 μM), and sodium channel (IC50 = 5.1 μM). BGC-201259 demonstrates synergistic potential in improving cognitive and emotional symptoms by balancing the inhibition of these two targets. BGC-201259 can be used in research on Alzheimer's disease.
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Multi-target kinase-IN-6
0 ImagesCat. No.: HY-178344Multi-target kinase-IN-6 is a Multiple target kinase inhibitor. Multi-target kinase-IN-6 can inhibit cardiac RyR2- and NaV1.5-channels but stimulate SERCA2a pump activity. Multi-target kinase-IN-6 can be used for the research of cardiovascular disease, such as heart failure.
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711389-S hydrochloride
0 ImagesCat. No.: HY-19004CAS No.: 94899-83-9711389-S hydrochloride is an antiarrhythmic compound that demonstrates its antiarrhythmic activity by increasing the ventricular fibrillation threshold (VFT). 711389-S hydrochloride also has strong anti-fibrillation effects and safety, and can be used in the study of ventricular fibrillation and sudden cardiac death. 711389-S hydrochloride also inhibits the sodium current.
