Vasopressin Receptor
The neurohypophysial hormone arginine vasopressin (AVP) is involved in diverse functions including regulation of body fluid homeostasis, vasoconstriction, and adrenocorticotropic hormone release. These physiological effects are mediated by three subtypes of vasopressin receptors, designated V1a, V1b (or V3), and V2. They all belong to the large rhodopsin-like G-protein-coupled receptor family.
The V1a receptor is expressed in both neuronal and non-neuronal tissues including the heart and elicits a variety of physiological effects including cell contraction and proliferation, stimulation of hepatic glycogenolysis, platelet aggregation and coagulation factor release. The V1b receptor subtype is found predominantly in the pituitary gland where it stimulates adrenocorticotropic hormone release. Both the V1a and V1b AVP receptors act through a G protein alpha-subunit of the Gαq family (αq, q11, q14, α15/16) to activate phospholipase C-β, and, thus enhance cellular IP3 and calcium levels. By contrast, the V2 receptor subtype is localized predominantly to the kidney where it mediates the anti-diuretic effects of AVP through the heterotrimeric G protein Gs and activation of adenylyl cyclase.
Vasopressin Receptor Isoform Specific Products
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Vasopressin Receptor Inhibitors
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Vasopressin Receptor Agonists
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Vasopressin Receptor Antagonists
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Vasopressin Receptor Activators
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Vasopressin Receptor Modulator
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Vasopressin Receptor Ligand
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Vasopressin Receptor Related Products (126)
Related Products (126)
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Vasopressin Receptor Isoform Comparison
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SRX246
0 ImagesSRX246 is a potent, BBB-penetrant, highly selective vasopressin 1a (V1a) receptor antagonist (Ki=0.3 nM for human V1a). SRX246 has no interaction at V1b and V2 receptors. SRX246 also displays negligible binding at 64 others receptors classes, including 35 G-proteincoupled receptors. SRX246 can be used for treatment of stress-related disorders.
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d[Cha4]-AVP
![d[Cha4]-AVP](https://file.medchemexpress.com/product_pic/hy-p1390.gif "Click to View d[Cha4]-AVP Product Detail")
0 Imagesd[Cha4]-AVP is a potent and selective vasopressin (AVP) V1b receptor agonist with a Ki of 1.2 nM for human V1b receptor. d[Cha4]-AVP shows more selective for V1b receptor than human V1a receptor, V2 receptor, and oxytocin receptors.
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WAY-151932
0 ImagesSynonyms: VNA-932; WAY-VNA 932WAY-151932 is a vasopressin V2-receptor agonist with IC50 of 80.3 nM and 778 nM in human-V2 binding and V1a binding assay.
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Argipressin acetate
0 ImagesSynonyms: Arg8-vasopressin acetate; AVP acetateArgipressin (Arg8-vasopressin) (acetate) binds to the V1, V2, V3-vascular arginine vasopressin receptor, with a Kd value of 1.31 nM in A7r5 rat aortic smooth muscle cells for V1.
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Selepressin acetate
0 ImagesCat. No.: HY-105239APurity: 98.04%Synonyms: FE 202158 acetateSelepressin (FE 202158) acetate is a selective vasopressin V1A receptor agonist. Selepressin acetate is a potent vasopressin. Selepressin acetate can be used in the study of septic shock.
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Ornipressin
0 ImagesOrnipressin (POR-8) is a vasopressin agonist specific for the V1 receptor. Ornipressin can be used as a local vasoconstrictor. Ornipressin can reverse the hypotension associated with combine general/epidural anesthesia. Ornipressin has antidiuretic activity. Ornipressin decreases renal vascular resistance and increases renal blood flow in renal failure model.
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Felypressin acetate
0 ImagesSynonyms: PLV-2 acetateFelypressin acetate (PLV-2 acetate) is a non-catecholamine vasoconstrictor and a vasopressin 1 agonist. Felypressin acetate is widely used in dental procedures.
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OPC-51803
0 ImagesOPC-51803 is an orally active nonpeptide vasopressin V2 receptor agonist. OPC-51803 can be used for the research of micturition disorders that result in frequent micturition, such as that from polyuria, nocturnal polyuria, and some kinds of urinary incontinence.
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Fedovapagon
0 ImagesSynonyms: VA106483Fedovapagon (VA106483) is a selective and orally active vasopressin V2 receptor (V2R) agonist with an EC50 of 24 nM. Fedovapagon can be used in the research of nocturia.
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Fuscoside
0 ImagesSynonyms: OPC-21268Fuscoside (OPC-21268) is an orally effective, nonpeptide, vasopressin V1 receptor antagonist with an IC50 of 0.4 μM.
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TASP0390325
0 ImagesTASP0390325 is a high affinity and orally active arginine vasopressin receptor 1B (V1B receptor) antagonist with antidepressant and anxiolytic activities.
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Lysipressin acetate
0 ImagesSynonyms: Lysine vasopressin acetate; [Lys8]-Vasopressin acetateLysipressin acetate (Lysine vasopressin acetate; [Lys8]-Vasopressin acetate) is a neurohypophyseal nonapeptide with dual cardiovascular regulatory activities of peripheral pressor action and central hypotensive action, and it also regulates pain perception in the body. Lysipressin acetate is an Oxytocin Receptor agonist, with a Ki value of 10.2 nM for porcine OT receptor. Lysipressin acetate stimulates contraction of rabbit bladder smooth muscle via V1-vasopressin receptor. The central hypotensive effect of Lysipressin acetate depends on the sympathetic tone pathway. Lysipressin acetate dose-dependently prolongs tail-flick latency in rats, producing a stable central antinociceptive effect. Lysipressin acetate can be used in studies related to cardiovascular regulation, hypertension and pain.
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Big Endothelin-1 (1-38), human
0 ImagesBig Endothelin-1 (1-38), human is the precursor of endothelin-1. Endothelin-1 (ET-1) is a potent vasopressor peptide.
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TC OT 39
0 ImagesCat. No.: HY-108678CAS No.: 479232-57-0TC OT 39 is a synthetic oxytocin analog, as well as a selective agonist of oxytocin receptor (OXTR, EC50=180 nM). TC OT 39 is also an Avprla vasopressin receptor antagonist with an Ki value of 330 nM. TC OT 39 exhibits sedative effects in mouse models.
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Velmupressin acetate
0 ImagesSynonyms: c(Bua-Cpa-Thi-Val-Asn-Cys)-Pro-d-Arg-NEt2 acetateVelmupressin (c(Bua-Cpa-Thi-Val-Asn-Cys)-Pro-d-Arg-NEt2) acetate is a potent, selective and short-acting peptidic V2 receptor (V2R) agonist with EC50s of 0.07 and 0.02 nM for hV2R and rV2R, respectively.
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Vasopressin V2 receptor antagonist 2
0 ImagesVasopressin V2 receptor antagonist 2 (Compound 33) is an antagonist of the arginine vasopressin V2 receptor (V2R) with a Ki value of 6.2 nM. Vasopressin V2 receptor antagonist 2 can effectively reduce cAMP levels, thereby inhibiting the growth of renal cysts[1].
