2. GPCR/G Protein Apoptosis
  3. Vasopressin Receptor Apoptosis
  4. Antagonist G

Antagonist G is a potent vasopressin antagonist. Antagonist G is also a weak antagonist of GRP and Bradykinin. Antagonist G induces AP-1 transcription and sensitizes cells to chemotherapy.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

Antagonist G Chemical Structure

Antagonist G Chemical Structure

CAS No. : 115150-59-9

Size Price Stock Quantity
5 mg USD 180 In-stock
10 mg USD 290 In-stock
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100 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

Other Forms of Antagonist G:

Antagonist G Related Antibodies

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  • Biological Activity

  • Purity & Documentation

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Description

Antagonist G is a potent vasopressin antagonist. Antagonist G is also a weak antagonist of GRP and Bradykinin. Antagonist G induces AP-1 transcription and sensitizes cells to chemotherapy[1][2].

In Vitro

Antagonist G (0-100 μM) induces apoptosis is redox-sensitive and caspase-dependently in SCLC cells[2].
Antagonist G activates JNK1 in SCLC cells[2].
Antagonist G is not intrinsically a free radical oxygen donor but stimulates free radical generation specifically within SCLC cells (6.2-fold) and increases the activity of the redox-sensitive transcription factor AP-1 by 61%[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Antagonist G Related Antibodies

Cell Viability Assay[2]

Cell Line: SCLC cell lines NCI-H69, NCI-H510 and CHO-K1 cells.
Concentration: 0-100 μM.
Incubation Time: 24 h.
Result: Inhibited cell growh.
Molecular Weight

951.19

Formula

C49H66N12O6S
CAS No.
Appearance

Solid

Color

Off-white to light yellow

Sequence Shortening

RW-{Me-Phe}-WLM-NH2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture and light

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

H2O : 50 mg/mL (52.57 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.0513 mL 5.2566 mL 10.5131 mL
5 mM 0.2103 mL 1.0513 mL 2.1026 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

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C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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(per animal)

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 1.0513 mL 5.2566 mL 10.5131 mL 26.2829 mL
5 mM 0.2103 mL 1.0513 mL 2.1026 mL 5.2566 mL
10 mM 0.1051 mL 0.5257 mL 1.0513 mL 2.6283 mL
15 mM 0.0701 mL 0.3504 mL 0.7009 mL 1.7522 mL
20 mM 0.0526 mL 0.2628 mL 0.5257 mL 1.3141 mL
25 mM 0.0421 mL 0.2103 mL 0.4205 mL 1.0513 mL
30 mM 0.0350 mL 0.1752 mL 0.3504 mL 0.8761 mL
40 mM 0.0263 mL 0.1314 mL 0.2628 mL 0.6571 mL
50 mM 0.0210 mL 0.1051 mL 0.2103 mL 0.5257 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Antagonist G Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Antagonist G115150-59-9Vasopressin ReceptorApoptosisSCLCsmallcelllungcancerNCI-H69NCI-H510CHO-K1Inhibitorinhibitorinhibit

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