Vasopressin Receptor
The neurohypophysial hormone arginine vasopressin (AVP) is involved in diverse functions including regulation of body fluid homeostasis, vasoconstriction, and adrenocorticotropic hormone release. These physiological effects are mediated by three subtypes of vasopressin receptors, designated V1a, V1b (or V3), and V2. They all belong to the large rhodopsin-like G-protein-coupled receptor family.
The V1a receptor is expressed in both neuronal and non-neuronal tissues including the heart and elicits a variety of physiological effects including cell contraction and proliferation, stimulation of hepatic glycogenolysis, platelet aggregation and coagulation factor release. The V1b receptor subtype is found predominantly in the pituitary gland where it stimulates adrenocorticotropic hormone release. Both the V1a and V1b AVP receptors act through a G protein alpha-subunit of the Gαq family (αq, q11, q14, α15/16) to activate phospholipase C-β, and, thus enhance cellular IP3 and calcium levels. By contrast, the V2 receptor subtype is localized predominantly to the kidney where it mediates the anti-diuretic effects of AVP through the heterotrimeric G protein Gs and activation of adenylyl cyclase.
Vasopressin Receptor Isoform Specific Products
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Vasopressin Receptor Inhibitors
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Vasopressin Receptor Agonists
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Vasopressin Receptor Antagonists
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Vasopressin Receptor Activators
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Vasopressin Receptor Modulator
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Vasopressin Receptor Ligand
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Vasopressin Receptor Related Products (126)
Related Products (126)
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Vasopressin Receptor Isoform Comparison
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Ornipressin acetate
0 ImagesSynonyms: POR-8 acetateOrnipressin (POR-8) acetate is a potent vasoconstrictor, hemostatic and renal agent. Ornipressin acetate is a vasopressin agonist specific for the V1 receptor. Ornipressin acetate can be used as a local vasoconstrictor. Ornipressin acetate can reverse the hypotension associated with combine general/epidural anesthesia. Ornipressin acetate has antidiuretic activity. Ornipressin acetate decreases renal vascular resistance and increases renal blood flow in renal failure model.
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RG7713
0 ImagesSynonyms: RO5028442RG7713 (RO5028442) is a highly potent, selective and brain-penetrant Vasopressin 1a (V1a) receptor antagonist with Kis of 1 nM (hV1a) and 39 nM (mV1a).
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Lazuvapagon
0 ImagesCat. No.: HY-109181CAS No.: 2379889-71-9Synonyms: SK-1404; KRP-N118Lazuvapagon (SK-1404) is a vasopressin V2 receptor agonist for the research of nocturia.
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Brezivaptan
0 ImagesCat. No.: HY-159507CAS No.: 1370444-22-6Synonyms: Brezivaptanum; TH1773; TS-121Brezivaptan (Brezivaptanum; TH1773; TS-121) is a vasopressin receptor antagonist.
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Terlipressin acetate
0 ImagesCat. No.: HY-12554BCAS No.: 914453-96-6Terlipressin acetate is a vasopressin analogue with potent vasoactive properties. Terlipressin acetate is a highly selective vasopressin V1 receptor agonist that reduces the splanchnic blood flow and portal pressure and controls acute variceal bleeding. Terlipressin acetate exerts anti-inflammatory and anti-oxidative effects. Terlipressin acetate has the potential for hepatorenal syndrome and norepinephrine-resistant septic shock research.
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Terlipressin
0 ImagesCat. No.: HY-12554CAS No.: 14636-12-5Terlipressin is a vasopressin analogue with potent vasoactive properties. Terlipressin is a highly selective vasopressin V1 receptor agonist that reduces the splanchnic blood flow and portal pressure and controls acute variceal bleeding. Terlipressin exerts anti-inflammatory and anti-oxidative effects. Terlipressin has the potential for hepatorenal syndrome and norepinephrine-resistant septic shock research.
![[Arg8]-Vasotocin TFA](https://file.medchemexpress.com/product_pic/hy-p1574a.gif "Click to View [Arg8]-Vasotocin TFA Product Detail")
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Tolvaptan phosphate ester sodium
0 ImagesTolvaptan phosphate ester sodium, a prodrug of Tolvaptan (HY-17000), can be used in the study of cardiac edema. Tolvaptan is a selective, competitive and orally active vasopressin receptor 2 (V2R) antagonist with an IC50 of 1.28 μM for the inhibition of arginine vasopressin (AVP)-induced platelet aggregation.
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SKF 100398
0 ImagesSynonyms: d(CH2)5Tyr(Et)VAVPSKF 100398 (d(CH2)5Tyr(Et)VAVP), an arginine vasopressin (AVP) analogue, is a specific antagonist of the antidiuretic effect of exogenous and endogenous AVP.
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Vasopressin Dimer (parallel) TFA
0 ImagesCat. No.: HY-P5213Purity: 99.55%Vasopressin Dimer (parallel) TFA is a parallel dimer of Vasopressin (HY-B1811). Vasopressin Dimer (parallel) TFA can activate four G protein-coupled receptors, V1aR, V1bR, V2R, and OTR.
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(Phenylac1,D-Tyr(Et)2,Lys6,Arg8,des-Gly9)-Vasopressin
0 ImagesCat. No.: HY-P4683CAS No.: 129520-65-6(Phenylac1,D-Tyr(Et)2,Lys6,Arg8,des-Gly9)-Vasopressin is a potent vasopressin V1 receptor (VP V1R) antagonist. (Phenylac1,D-Tyr(Et)2,Lys6,Arg8,des-Gly9)-Vasopressin significantly decreases the mean arterial pressure (MAP) in rats.
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[8-L-arginine] deaminovasopressin
![[8-L-arginine] deaminovasopressin](https://file.medchemexpress.com/product_pic/hy-p4237.gif "Click to View [8-L-arginine] deaminovasopressin Product Detail")
0 ImagesSynonyms: dAVP[8-L-arginine] deaminovasopressin (dAVP) is a vasopressin analog.
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c(Bua-Cpa-Thi-Val-Asn-Cys)-Pro-Agm
0 ImagesCat. No.: HY-P1810CAS No.: 1647119-71-8c(Bua-Cpa-Thi-Val-Asn-Cys)-Pro-Agm is a is a potent, selective and short-acting peptidic V2 receptor (V2R) agonist with EC50s of 0.25 and 0.05 nM for hV2R and rV2R, respectively.
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Velmupressin
0 ImagesCat. No.: HY-P1809CAS No.: 1647119-61-6Synonyms: c(Bua-Cpa-Thi-Val-Asn-Cys)-Pro-d-Arg-NEt2Velmupressin (c(Bua-Cpa-Thi-Val-Asn-Cys)-Pro-d-Arg-NEt2) is a potent, selective and short-acting peptidic V2 receptor (V2R) agonist with EC50s of 0.07 and 0.02 nM for hV2R and rV2R, respectively.
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Argipressin diacetate
0 ImagesCat. No.: HY-P0049ACAS No.: 75499-44-4Synonyms: Arg8-vasopressin diacetate; AVP diacetate; ADHArgipressin (diacetate) (AVP (diacetate), also known as antidiuretic hormone (ADH)) is a 9 amino acid neuropeptide secreted by the posterior pituitary. Argipressin (diacetate) (AVP (diacetate)) can regulate the biological effects of fluid balance, osmolality and cardiovascular through three separate G-protein coupled receptors (GPCRs), namely Avpr1a (V1a), Avpr1b (V1b) and Avpr2 (V2). Argipressin (diacetate) (AVP (diacetate)) also have potentially important effects on centrally regulated metabolic processes.
![d[Cha4]-AVP TFA](https://file.medchemexpress.com/product_pic/hy-p1390a.gif "Click to View d[Cha4]-AVP TFA Product Detail")
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Vasopressin V2 receptor antagonist 1
0 ImagesCat. No.: HY-146272CAS No.: 2648650-50-2Vasopressin V2 receptor antagonist 1 is a vasopressin V2 receptor (V2R) antagonist with a Ki value of 3.8 nM. Vasopressin V2 receptor antagonist 1 inhibits renal cyst formation in embryonic renal cyst models and mouse models. Vasopressin V2 receptor antagonist 1 can be used in research related to autosomal dominant polycystic kidney disease.
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Docarpamine
0 ImagesCat. No.: HY-W752502CAS No.: 74639-40-0Docarpamine is an orally active dopamine prodrug that can be hydroxylated in the small intestine and liver to form active dopamine. Docarpamine mainly activates D1-like receptors in peripheral blood vessels to lower blood pressure and heart rate in a state of spontaneous hypertension. Docarpamine exerts a pressor and tachycardic effect by activating D1-like receptors, vasopressin V1 receptors, and α-adrenergic receptors in normal blood pressure conditions. Docarpamine can be used for research on renal vascular dilation and diuresis.
