1. GPCR/G Protein
  2. Vasopressin Receptor
  3. WAY-151932

WAY-151932 (Synonyms: VNA-932; WAY-VNA 932)

Cat. No.: HY-19381
Handling Instructions

WAY-151932 is a vasopressin V2-receptor agonist with IC50 of 80.3 nM and 778 nM in human-V2 binding and V1a binding assay.

For research use only. We do not sell to patients.

WAY-151932 Chemical Structure

WAY-151932 Chemical Structure

CAS No. : 220460-92-4

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Description

WAY-151932 is a vasopressin V2-receptor agonist with IC50 of 80.3 nM and 778 nM in human-V2 binding and V1a binding assay.

IC50 & Target

IC50: 80.3 nM (human-V2 binding), 778 nM (human-V1a binding)[1]

In Vitro

WAY-151932 (VNA-932) stimulates cAMP formation in LV2 cells expressing the hV2 receptors in a dose-dependent manner with an EC50 of 0.74±0.07 nM[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Oral administration of WAY-151932 (VNA-932) to water-loaded conscious rats produces a dose-dependent decrease in urine volume (ED50=0.14 mg/kg, 2.5% starch in water vehicle) and a corresponding increase in osmolality without altering the urine electrolyte excretion profile[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

402.88

Formula

C₂₃H₁₉ClN₄O

CAS No.

220460-92-4

SMILES

O=C(C1=CC=C(N2N=C(C)C=C2)C=C1Cl)N3CC4=CC=CN4CC5=CC=CC=C53

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

WAY-151932VNA-932 WAY-VNA 932WAY151932WAY 151932VNA932VNA 932Vasopressin ReceptorInhibitorinhibitorinhibit

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Product Name:
WAY-151932
Cat. No.:
HY-19381
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