Identification and synthesis of major metabolites of Vasopressin V2-receptor agonist WAY-151932, and antagonist, Lixivaptan

  • Bioorg Med Chem Lett. 2007 Nov 1;17(21):5796-800. doi: 10.1016/j.bmcl.2007.08.053.
Albert J Molinari  1 ,  Eugene J Trybulski ,  Jehan Bagli ,  Susan Croce ,  John Considine ,  Jian Qi ,  Kadum Ali ,  William Demaio ,  Lynne Lihotz ,  David Cochran
Affiliations
  • 1. Chemical and Screening Sciences, Wyeth Research, 500 Arcola Road, Collegeville, PA 19426, USA. [email protected]
PMID: 17855087 DOI: 10.1016/j.bmcl.2007.08.053
Abstract

Small molecule agonists and antagonists of the V(2)-vasopressin receptor have been discovered and have undergone clinical trials. In conjunction with these discovery programs, the synthesis and biological testing of various metabolites associated with these clinical targets were actively pursued. We now report the results of our synthetic efforts and the corresponding biological data generated for several of the metabolites of WAY-151932 and CL-347985 (Lixivaptan).

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