Xanthine Oxidase
XO
Xanthine oxidase (XO), a versatile molybdoflavoprotein, catalyzes the oxidative hydroxylation of purine substrates (hypoxanthine and xanthine) to produce uric acid and subsequent reduction of oxygen at the flavin center with the generation of reactive oxygen species, either superoxide anion radical or hydrogen peroxide.
Xanthine oxidase is an important enzyme of purine catabolism pathway and has been associated directly in pathogenesis of gout and indirectly in many pathological conditions like cancer, diabetes and metabolic syndrome. The selective inhibition of xanthine oxidase may result in a broad spectrum therapeutic use for gout, cancer, inflammation and oxidative damage.
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Xanthine Oxidase Related Products (160)
Related Products (160)
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Antibodies (1)
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5-Hydroxy-3,4,7-triphenyl-2,6-benzofurandione
0 ImagesCat. No.: HY-N14414CAS No.: 114590-95-35-Hydroxy-3,4,7-triphenyl-2,6-benzofurandione is a xanthine oxidase (XO) inhibitor found in Peniophora sanguinea.
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Prudomestin (Standard)
0 ImagesPrudomestin (Standard) is the analytical standard of Prudomestin. This product is intended for research and analytical applications. Prudomestin, isolated from the heartwood of Prunus domestica, shows potent xanthine oxidase (XO) inhibitory activity (IC50≈6?μM).
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Imidazole (Standard)
0 ImagesSynonyms: Glyoxaline (Standard); 1,3-Diaza-2,4-cyclopentadiene (Standard)Imidazole (Standard) is the analytical standard of Imidazole. This product is intended for research and analytical applications. Imidazole (Glyoxaline; 1,3-Diaza-2,4-cyclopentadiene) is a heterocyclic aromatic compound. Imidazole bearing molecules have been used as corrosion, acetylcholinesterase (AChEI) and xanthine oxidase (XO) inhibitors, performing biological activities such as antifungal, antituberculosis, anti-inflammatory, antioxidant, and analgesic, amongst many others. Imidazole inhibits the enzymatic conversion of the endoperoxides (PGG2 and PGH2) to thromboxane A2 by platelet microsomes. Imidazole derivatives exhibits inhibition on SARS-CoV-2 3CLPro enzyme, which is promising for research in the field of Alzheimer’s disease, gout, COVID-19 and thrombo-embolic disease.
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Potassium oxonate (Standard)
0 ImagesSynonyms: Potassium azaorotate (Standard); Potassium otastat (Standard); Oteracil potassium (Standard)Potassium oxonate (Standard) is the analytical standard of Potassium oxonate (HY-17511). This product is intended for research and analytical applications. Potassium oxonate (Potassium azaorotate) is a uricase inhibitor that inhibits the phosphorylation of 5-FU to 5-fluorouridine-5'-monophosphate.
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Neosakuranin
0 ImagesCat. No.: HY-N17699CAS No.: 31187-54-9Neosakuranin is a flavonoid. Neosakuranin can be isolated from Sorbus commixta and the bark of P. cerasus. Neosakuranin exhibits suppressive effects on xanthine oxidase with an IC50 of 157.8 μM. Neosakuranin inhibits COX-l. Neosakuranin can be used in the research of inflammatory diseases.
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Phytic acid hexasodium
0 ImagesCat. No.: HY-N0814BCAS No.: 34367-89-0Synonyms: Inositol hexaphosphate hexasodium; SNF472Phytic acid (Inositol hexaphosphate) hexasodium is a phosphorus storage compound of seeds and cereal grains. Phytic acid hexasodium has a strong ability to chelate multivalent metal ions, specially zinc, calcium, iron and as with protein residue. Phytic acid hexasodium inhibits the enzymatic superoxide source xanthine oxidase (XO), and has antioxidative, neuroprotective, anti-inflammatory effects.
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Febuxostat-d5
0 ImagesCat. No.: HY-14268S3Synonyms: TEI 6720-d5; TMX 67-d5Febuxostat-d5 (TEI 6720-d5) is deuterium labeled Febuxostat. Febuxostat (TEI 6720) is a potent, selective and non-purine xanthine oxidase (XO) inhibitor with a Ki value of 0.6 nM. Febuxostat has the potential for the research of hyperuricemia and gout.
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Topiroxostat (Standard)
0 ImagesSynonyms: FYX-051 (Standard)Topiroxostat (Standard) is the analytical standard of Topiroxostat. This product is intended for research and analytical applications. Topiroxostat (FYX-051) is a potent and orally active xanthine oxidoreductase (XOR) inhibitor with an IC50 value of 5.3 nM and a Ki value of 5.7 nM. Topiroxostat exhibits weak CYP3A4-inhibitory activity (18.6%). Topiroxostat has the potential for hyperuricemia treatment.
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BOF-4272
0 ImagesCat. No.: HY-19164CAS No.: 142181-44-0BOF-4272 is a xanthine oxidase/xanthine dehydrogenase inhibitor. BOF-4272 can be used for hyperuricemia research.
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Hydroxyakalone
0 ImagesCat. No.: HY-N14777CAS No.: 182056-35-5Hydroxyakalone is an inhibitor of Xanthosine oxidase (XOD, EC 1.2.3.2), with an IC50 of 4.6 μM.
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Amflutizole
0 ImagesCat. No.: HY-119955CAS No.: 82114-19-0Synonyms: LY-141894Amflutizole (LY-141894) is an inhibitor of xanthine oxidase. Amflutizole abolishes free radical formation and release in cerebral ischemia/reperfusion mice.
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Xanthine oxidase-IN-14
0 ImagesCat. No.: HY-W560574CAS No.: 80025-67-8Xanthine oxidase-IN-14 (Compound 3f) is an inhibitor for xanthine oxidase, with IC50 >100 μM. Xanthine oxidase-IN-14 inhibits proliferations of cancer cells MCF-7, NCI-H460 and SF-268, with IC50 greater than 150 μM.
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Oxypurinol-13C,15N2-1
0 ImagesCat. No.: HY-W777649CAS No.: 1217036-71-9Synonyms: Oxipurinol-13C,15N2-1Oxypurinol-13C,15N2-1 (Oxipurinol-13C,15N2-1) is 15N and 13C labeled Oxypurinol (HY-19657). Oxipurinol, the major active metabolite of Allopurinoll (HY-B0219), is an inhibitor of xanthine oxidase. Oxipurinol can be used to regulate blood urate levels and treat gout.
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Xanthine oxidase-IN-22
0 ImagesCat. No.: HY-181095CAS No.: 3075445-37-0Xanthine oxidase-IN-22 is an orally active inhibitor of xanthine oxidase (XO) (IC50: 0.0034 μM). Xanthine oxidase-IN-22 exhibits a mixed-type inhibition mode against XO. Xanthine oxidase-IN-22 reduces serum uric acid levels in mice. Xanthine oxidase-IN-22 can be used in research related to hyperuricemia and gout.
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Nequinate (Standard)
0 ImagesCat. No.: HY-116433RCAS No.: 13997-19-8Nequinate (Standard) is the analytical standard of Nequinate. This product is intended for research and analytical applications. Nequinate, a quinoline compound, is an anticoccidial agent against cecal coccidiosis (Eimeria tenella) infections. Nequinate inhibits xanthine oxidoreductase (XOD) activity.
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4-Nitrocinnamic acid (Standard)
0 ImagesCat. No.: HY-W015069RCAS No.: 619-89-64-Nitrocinnamic acid (Standard) is the analytical standard of 4-Nitrocinnamic acid (HY-W015069). This product is intended for research and analytical applications. 4-Nitrocinnamic acid is a Phenylpropanoids product that can be isolated from the heartwoods of Cassia garrettiana.
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5,6,7-Trihydroxy-4'-methoxyflavone
0 Images5,6,7-Trihydroxy-4'-methoxyflavone (4'-O-Methylscutellarein) is a flavonoid and a weak inhibitor of xanthine oxidase. 5,6,7-Trihydroxy-4'-methoxyflavone possesses antithrombotic and antioxidant activities. 5,6,7-Trihydroxy-4'-methoxyflavone has an IC50 value of 25.29 µM for DPPH free radical scavenging. 5,6,7-Trihydroxy-4'-methoxyflavone can also inhibit H2O2-induced damage to PC12 cells. 5,6,7-Trihydroxy-4'-methoxyflavone is applicable for the research of diseases such as cerebrovascular disorders.
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Digallic acid
0 ImagesDigallic acid is an antioxidant, antimutagenic, antigenotoxic, and anti-hyperuricemic compound. Digallic acid is a reverse transcriptase and XOD, URAT1 (IC50: 5.34 μM) inhibitor. Digallic acid scavenges DPPH· and O2·− radicals. Digallic acid induces apoptosis. Digallic acid can be isolated from the fruits of Pistascia lentiscus.
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Azapropazone (Standard)
0 ImagesCat. No.: HY-116442RCAS No.: 13539-59-8Azapropazone (Standard) is the analytical standard of Azapropazone (HY-116442). This product is intended for research and analytical applications. Azapropazone is an orally active nonsteroidal anti-inflammatory agent. Azapropazone inhibits Xanthine oxidase activity with an IC50 of 70-140 μg/mL. Azapropazone exerts significant cardiomyocyte protective effects on dogs with ischemia-reperfusion injury. Azapropazone reduces arthritis. Azapropazone inhibits Adrenaline-induced platelet aggregation. Azapropazone can be used for the research of myocardial ischemia and reperfusion injury, adjuvant arthritis, and gouty arthritis.
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Xanthine oxidase-IN-1
0 ImagesCat. No.: HY-U00288CAS No.: 1071970-13-2Synonyms: 4-(3-Cyano-5,6-difluoroindol-1-yl)-2-hydroxybenzoic acidXanthine oxidase-IN-1 is a xanthine oxidase inhibitor extracted from patent WO2008126898A1, page 68, compound example 3, with an IC50 of 6.5 nM.
