Xanthine Oxidase
XO
Xanthine oxidase (XO), a versatile molybdoflavoprotein, catalyzes the oxidative hydroxylation of purine substrates (hypoxanthine and xanthine) to produce uric acid and subsequent reduction of oxygen at the flavin center with the generation of reactive oxygen species, either superoxide anion radical or hydrogen peroxide.
Xanthine oxidase is an important enzyme of purine catabolism pathway and has been associated directly in pathogenesis of gout and indirectly in many pathological conditions like cancer, diabetes and metabolic syndrome. The selective inhibition of xanthine oxidase may result in a broad spectrum therapeutic use for gout, cancer, inflammation and oxidative damage.
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Xanthine Oxidase Related Products (163)
Related Products (163)
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Antibodies (1)
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(+/-)-Epicatechin
0 ImagesCat. No.: HY-W104467CAS No.: 13392-26-2Synonyms: (+/-)-Epicatechol; (+/-)-epi-Catechin(+/-)-Epicatechin is a xanthine oxidase inhibitor with an IC50 of 982.14 μM, and can be found in Semen Plantaginis (Plantago seed). (+/-)-Epicatechin can be used in research on diseases such as hyperuricemia and gout .
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Tetrahydroamentoflavone
0 ImagesCat. No.: HY-N1162CAS No.: 48236-96-0Synonyms: AmentoflavanoneTetrahydroamentoflavone (Amentoflavanone) is a potent xanthine oxidase (XO) inhibitor. Tetrahydroamentoflavone has inhibitory activity for XO with IC50 and Ki values of 92 nM and 0.982 μM, respectively. Tetrahydroamentoflavone can be used for the research of inflammatory disorders and gout.
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Xanthine oxidase-IN-9
0 ImagesCat. No.: HY-N10433CAS No.: 2571069-61-7Synonyms: Icarisids EXanthine oxidase-IN-9 (Icarisids E) (Compound 2) is a potent xanthine oxidase (XOD) inhibitor with an IC50 of 31.81 μM.
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Morin 3-O-β-D-glucopyranoside
0 ImagesCat. No.: HY-N10411CAS No.: 1169766-14-6Morin 3-O-β-D-glucopyranoside is a natural flavonoid with antifungal, anticancer and antioxidant activities. Morin 3-O-β-D-glucopyranoside inhibits reverse transcriptase, protein-tyrosine kinase and xanthine oxidase, and also shows anti-HIV, antiarteriosclerotic, and superoxide scavenging activities.
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2-Methylacetophenone (Standard)
0 ImagesSynonyms: O-Methylacetophenone (Standard)2-Methylacetophenone (O-Methylacetophenone) (Standard) is the analytical standard of 2-Methylacetophenone (HY-W012658). This product is intended for research and analytical applications. 2-Methylacetophenone (O-Methylacetophenone), acetophenone derivative and acaricide, is a xanthine dehydrogenase (XDH) inhibitor. 2-Methylacetophenone competitively binds to the XDH active site, blocking the pathway for xanthine to be converted to uric acid. 2-Methylacetophenone can be used for the study of hyperuricemia and house dust.
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Prudomestin
0 ImagesPrudomestin, isolated from the heartwood of Prunus domestica, shows potent xanthine oxidase (XO) inhibitory activity (IC50≈6 µM).
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Febuxostat 67M-1
0 ImagesCat. No.: HY-131321CAS No.: 887945-96-2Febuxostat 67M-1 is an active metabolite of Febuxostat (HY-14268). Febuxostat 67M-1 retains inhibitory activity against Xanthine Oxidase, but its plasma concentration is much lower than that of Febuxostat. Febuxostat 67M-1 can be used in the research of hyperuricemia.
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Xanthine oxidase-IN-4
0 ImagesCat. No.: HY-144303CAS No.: 2642137-96-8Xanthine oxidase-IN-4 (compound 19a) is an orally active and potent xanthine oxidase (XO) inhibitor, with an IC50 of 0.039 μM. Xanthine oxidase-IN-4 exhibits hypouricemic potency in potassium oxonate induced hyperuricemia rats. Xanthine oxidase-IN-4 can be used for hyperuricemia and gout research.
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1,4-Dicaffeoylquinic acid (Standard)
0 Images1,4-Dicaffeoylquinic acid (Standard) (1,4-DCQA (Standard)) is the analytical standard of 1,4-Dicaffeoylquinic acid (HY-N0358). This product is intended for research and analytical applications. 1,4-Dicaffeoylquinic acid (1,4-DCQA) is a phenylpropanoid compound that can be isolated from Xanthii fructus and an inhibitor of xanthine oxidase (IC50: 7.36 μM). 1,4-Dicaffeoylquinic acid has anti-inflammatory activity and can inhibit the production of TNF-α induced by LPS (HY-D1056).
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Allopurinol-13C,15N2
0 ImagesCat. No.: HY-B0219S1Allopurinol-13C,15N2 is the 13C- and 15N-labeled labeled Allopurinol (HY-B0219). Allopurinol is a potent and orally active xanthine oxidase inhibitor with an IC50 value of 0.2-50 μM. Allopurinol can be used in the research of hyperuricemia and gout. Allopurinol decreases the expression of HIF-1α and HIF-2α protein. Allopurinol shows anti-depressant and anti-nociception activity. Anti-leishmanial effect.
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AA 193
0 ImagesCat. No.: HY-106300CAS No.: 107804-48-8AA 193 is an orally active uricosuric agent. AA 193 inhibits the net reabsorption of uric acid in nephrons, regulates the renal reabsorption process of filtered uric acid, promotes uric acid excretion in a dose-dependent manner, and reduces serum uric acid levels. AA 193 mildly inhibits the activity of xanthine dehydrogenase (XDH). AA 193 can be used in studies related to hyperuricemia.
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Protosappanin A dimethyl acetal
0 ImagesCat. No.: HY-N10108CAS No.: 868405-37-2Protosappanin A dimethyl acetal is a homoisoflavonoid. Protosappanin A dimethyl acetal can be isolated from Caesalpinia sappan. Protosappanin A dimethyl acetal is also a competive inhibitor with significant xanthine oxidase inhibitory activity (IC50=50.7 μM).
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Cholesterol oxidase, rhodococcus sp
0 ImagesCholesterol oxidase, rhodococcus sp (ChOx, rhodococcus sp) (EC 1.1.3.6) is a cholesterol oxidase identified from bacterial sources. Cholesterol oxidase, rhodococcus sp catalyzes the oxidation of cholesterol to 4-cholesten-3-one, while simultaneously reducing oxygen to hydrogen peroxide. Cholesterol oxidase, rhodococcus sp retains its enzymatic activity and exhibits improved catalytic efficiency upon immobilization. Cholesterol oxidase, rhodococcus sp is applicable for cholesterol detection, steroid biotransformation, and research on tuberculosis-related diseases.
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Carbazeran citrate
0 ImagesCat. No.: HY-108680CAS No.: 153473-94-0Carbazeran citrate is a phosphodiesterase inhibitor. Carbazeran citrate is oxidized by aldehyde oxidase/AOX1 to 4-oxo-Carbazeran citrate/hydroxyCarbazeran citrate, serving as an AOX1 probe and competitively inhibiting xanthine oxidase. Carbazeran citrate can be used in research on congestive heart failure and chronic heart failure.
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6-Formylpterin (Standard)
0 ImagesCat. No.: HY-113978RCAS No.: 712-30-16-Formylpterin (Standard) is the analytical standard of 6-Formylpterin. This product is intended for research and analytical applications. 6-Formylpterin is an inhibitor of Xanthine Oxidase. 6-Formylpterin induces intracellular ROS generation and apoptosis in HL-60 cells. 6-Formylpterin suppresses cell proliferation in PanC-1 cells.
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Xanthine oxidase-IN-15
0 ImagesCat. No.: HY-161514CAS No.: 2982794-86-3Xanthine oxidase-IN-15 (Compound 6c) is a selective inhibitor of Xanthine oxidase (XO) (IC50=0.13 μM). Xanthine oxidase-IN-15 inhibits XO catalysis by forming a stable interaction with the active site of XO. Xanthine oxidase-IN-15 is mainly used in the study of hyperuricemia and gout.
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Purpurogallin (Standard)
0 ImagesPurpurogallin (Standard) is the analytical standard of Purpurogallin. This product is intended for research and analytical applications. Purpurogallin is a naturally phenol extracted from the plants of Quercus spp, has potent xanthine oxidase (XO) inhibitory activity with an IC50 of 0.2 μM. Purpurogallin has antioxidant and anti-inflammatory effects.
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Lithospermic acid (Standard)
0 ImagesCat. No.: HY-N0823RCAS No.: 28831-65-4Synonyms: (+)-Lithospermic acid (Standard)Lithospermic acid (Standard) is the analytical standard of Lithospermic acid. This product is intended for research and analytical applications. Lithospermic acid ((+)-Lithospermic acid) is a plant-derived polycyclic phenolic carboxylic acid isolated from Salvia miltiorrhiza, and has the anti-oxidative and hepatoprotective activity on carbon tetrachloride (CCl4)-induced acute liver damage in vitro and in vivo.
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Xanthine oxidase-IN-21
0 ImagesCat. No.: HY-180271Xanthine oxidase-IN-21, a Genipin (HY-17389) derivative, is an orally active mixed competitive xanthine oxidase (XOD) inhibitor with an IC50 of 0.68 μM. Xanthine oxidase-IN-21 reduces renal fibrosis by decreasing α-SMA expression and suppresses pro-inflammatory cytokines IL-1β, IL-6, and TNF-α through NF-κB pathway regulation. Xanthine oxidase-IN-21 also inhibits URAT1 and GLUT9 expression, promoting uric acid excretion and lowering serum uric acid levels. Xanthine oxidase-IN-21 shows significantly hepatorenal protection activity. Xanthine oxidase-IN-21 can be used for the research of hyperuricemia.
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Febuxostat-d3
0 ImagesCat. No.: HY-14268S2Synonyms: TEI 6720-d3; TMX 67-d3Febuxostat-d3 (TEI 6720-d3) is deuterium labeled Febuxostat. Febuxostat (TEI 6720) is a potent, selective and non-purine xanthine oxidase (XO) inhibitor with a Ki value of 0.6 nM. Febuxostat has the potential for the research of hyperuricemia and gout.
