Amino Acid Derivatives

Amino Acid Derivatives are bioactive molecules formed through chemical modifications or metabolic transformations of amino acids. They are widely present in living organisms and play crucial roles in physiological, psychological, and athletic performance.
The functions of these derivatives primarily include enhancing energy supply, regulating neurotransmitters, promoting fat metabolism, and reducing muscle damage. For example, creatine can increase muscle strength, enhance ATP resynthesis, and improve short-duration high-intensity exercise performance; tyrosine, as a precursor of dopamine and norepinephrine, helps enhance cognitive function and improve mood, particularly in sleep deprivation conditions, exhibiting anti-fatigue effects; carnitine facilitates fatty acid oxidation in the heart and skeletal muscles, improving endurance performance; HMB (β-hydroxy-β-methylbutyrate) reduces muscle breakdown and promotes muscle mass gain; while taurine exhibits antioxidant and antihypertensive properties and reduces oxidative stress induced by exercise.
Metabolic abnormalities or improper supplementation of amino acid derivatives may be associated with various diseases. For instance, tyrosine metabolism disorders can disrupt neurotransmitter balance, potentially leading to depression or stress-related disorders; elevated ADMA (asymmetric dimethylarginine) levels can inhibit nitric oxide synthesis, increasing the risk of cardiovascular diseases; carnitine deficiency is linked to certain genetic muscle disorders, impairing fat metabolism and energy production. Additionally, HMB may help slow muscle loss under specific conditions, while taurine intake is associated with improved cardiovascular health. Although some of the effects of these derivatives remain debated, they hold significant potential applications in sports nutrition, neurological regulation, and metabolic health.

References:

[1]. Luckose F, et al. Effects of amino acid derivatives on physical, mental, and physiological activities. Crit Rev Food Sci Nutr. 2015;55(13):1793-807. [Content Brief]

Amino Acid Derivatives Related Products (1734):

By Effects:	Inhibitor (1) Chemical (1)

Cat. No.	Product Name	Effect	Purity	Chemical Structure

HY-W099595

Ethyl Lauroyl Arginate Hydrochloride		99.8%
Ethyl Lauroyl Arginate Hydrochloride is an arginine derivative.

HY-P4632

H-γ-Glu-Leu-OH		99.21%
H-γ-Glu-Leu-OH (γ-Glu-Leu) is a dipeptide consisting of γ-glutamic acid and leucine, terminated by a hydroxyl group.

HY-W048739

Fmoc-α-Me-Leu-OH		99.90%
Fmoc-α-Me-Leu-OH is a leucine derivative with an Fmoc protecting group, which can be used to synthesize peptides with oxytocin receptor agonist activity.

HY-160429

PSAR18-COOH		99.50%
PSAR18-COOH (Ac-PSAR18-COOH) is a polysarcosine PSAR derivative. PSAR is a biodegradable, non-immunogenic polymer that has been used in a variety of compounds or diagnostic delivery systems. PSAR18 can be used as a component of ADC linkers.

HY-W010836

Fmoc-Bip(4,4')-OH		99.76%
Fmoc-Bip(4,4')-OH is an alanine derivative.

HY-W010862

Fmoc-Lys(Alloc)-OH		99.77%
Fmoc-Lys(Alloc)-OH is a lysine derivative.

HY-W008371

Fmoc-Met-OH		99.86%
Fmoc-Met-OH is a Methionine (HY-13694) derivative.

HY-W010732

Fmoc-L-Lys(ivDde)-OH		99.90%
Fmoc-L-Lys(ivDde)-OH is a lysine derivative.

HY-79676

Methyl (R)-2-((tert-butoxycarbonyl)amino)-3-iodopropanoate		99.96%
Methyl (R)-2-((tert-butoxycarbonyl)amino)-3-iodopropanoate is an alanine derivative.

HY-W008688

Fmoc-L-Norleucine		99.85%
Fmoc-L-Norleucine is a leucine derivative.

HY-41121

Boc-L-Ala-OH		99.07%
Boc-L-Ala-OH (Boc-Ala-OH) is a single N-protected amino acid ligand and a protected L-alanine derivative. Boc-L-Ala-OH promotes Pd (II)-catalyzed enantioselective C-H alkenylation and kinetic resolution. Boc-L-Ala-OH serves as a coupling reagent for the synthesis of liver-targeted glycogen phosphorylase inhibitors and P6A metabolites, and also acts as a negative control in synthesis studies of betulinic acid amino acid esters. Boc-L-Ala-OH is applicable to research on epidermoid squamous cell carcinoma.

HY-I0172

L-tert-Leucine Methyl Ester Hydrochloride		98.0%
L-tert-Leucine Methyl Ester Hydrochloride is a leucine derivative.

HY-Y0511

N,N-Dimethylglycine		98.0%
N,N-Dimethylglycine (Dimethylglycine), a natural N-methylated glycine, is a nutrient supplement and acts as an NMDAR glycine site partial agonist. N,N-Dimethylglycine is a methyl donor that can improve immunity, act as an antioxidant to prevent oxidative stress, and scavenge excess free radicals. N,N-Dimethylglycine has antidepressant-like and surfactant effects.

HY-W008876

Fmoc-Pen(Trt)-OH		99.93%
Fmoc-Pen(Trt)-OH is an amino acid derivative with an Fmoc protecting group that can be used to synthesize the inhibitory cystine knot (ICK) peptide ProTx-II.

HY-W048688

Fmoc-Trp(Me)-OH		99.66%
Fmoc-Trp(Me)-OH is an amino acid derivative. Fmoc-Trp(Me)-OH is formed by introducing a methyl group onto the nitrogen atom (N-1 position) of the indole ring of tryptophan (Trp) and protecting the amino group with Fmoc (9-fluorenylmethyloxycarbonyl). Fmoc-Trp(Me)-OH can be used in the synthesis of proteins or peptides.

HY-W010964

Fmoc-Hyp(tBu)-OH		99.28%
Fmoc-Hyp(tBu)-OH is a proline derivative.

HY-W005144

Boc-Lys(Fmoc)-OH		99.60%
Boc-Lys(Fmoc)-OH is a lysine derivative.

HY-111434A

N6-[(2-Azidoethoxy)carbonyl]-L-lysine hydrochloride		98.0%
N6-[(2-Azidoethoxy)carbonyl]-L-lysine hydrochloride (UAA crosslinker 1 hydrochloride) is a click chemistry-reactive amino acid derivative. N6-[(2-Azidoethoxy)carbonyl]-L-lysine hydrochloride mediates the generation of antibody-drug conjugates (ADCs). N6-[(2-Azidoethoxy)carbonyl]-L-lysine hydrochloride is used for site-specific incorporation into recombinant proteins, or for synthesizing chemical probes and tools for biological research.

HY-W041989

Fmoc-Oic-OH		99.86%
Fmoc-Oic-OH is an amino acid derivative with an Fmoc protecting group, which can be used to synthesize bioactive peptide mimetics, such as [desArg¹⁰]HOE 140, which has bradykinin B1 antagonist activity.

HY-W010276

H-Gly-Sar-OH		99.87%
H-Gly-Sar-OH is a Glycine (HY-Y0966) derivative.

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