2. Signaling Pathways
  3. Immunology/Inflammation
  4. BCL6
  5. BCL6 Inducer

BCL6 Inducer

BCL6 Inducer (1):

Cat. No. Product Name Effect Purity
  • HY-173364
    EB-TCIP
    		Inducer 99.58%
    EB-TCIP (BAK-04-212) is a proof-of-concept tool specifically designed for Ewing sarcoma research, serving as an EWSR1::FLI1 binder tagged with BCL6 and FKBP12F36V. EB-TCIP forms a ternary complex with the tagged fusion protein, specifically recruits EWSR1::FLI1 to BCL6-bound DNA loci, and induces rapid chromatin remodeling and relocalization. By mediating relocalization, EB-TCIP remodels the transcriptional machinery and activates the expression of BCL6 target genes that are originally repressed. EB-TCIP is used in studies related to novel epigenetic therapies for Ewing sarcoma.