E-Selectin Antagonist
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Rivipansel
0 ImagesCat. No.: HY-125475CAS No.: 927881-99-0Synonyms: GMI-1070Rivipansel (GMI-1070) is a small-molecule, glycomimetic pan-selectin antagonist that targets E-selectin, P-selectin, and L-selectin. Rivipansel binds tightly to the lectin domain of E-selectin, and selectively blocks the recognition of CD62L by E-selectin without affecting the binding of PSGL-1 to E-selectin. Rivipansel functionally inhibits the adhesion of hematopoietic cells to endothelial cells, and is applicable to research related to sickle cell disease.
